在研机构- |
最高研发阶段终止临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
分子式C25H26ClN5O4S |
InChIKeyLZLFEVJSMKCZGE-FJSYBICCSA-N |
CAS号204587-26-8 |
开始日期2016-07-14 |
申办/合作机构- |
开始日期2016-05-19 |
申办/合作机构 |
开始日期2016-05-04 |
申办/合作机构 |
适应症 | 最高研发状态 | 国家/地区 | 公司 |
---|---|---|---|
急性髓性白血病 | 终止 | - | |
晚期恶性实体瘤 | 终止 | - | |
非小细胞肺癌 | 终止 | - | |
弥漫性大B细胞淋巴瘤 | 终止 | - | |
血液肿瘤 | 无进展 | 意大利 更多 |
研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
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临床1期 | 9 | (MK-8628 20 mg AML Cohort) | 廠襯夢齋積觸壓簾範網(願構顧淵憲顧醖襯構範) = 憲膚廠蓋餘糧網襯餘膚 積構餘膚願廠壓餘醖壓 (鹽鑰鬱築製鹽淵積淵簾, 製淵顧顧鹽襯夢糧鬱選 ~ 襯積憲淵獵蓋窪繭繭鹹) 更多 | - | 2019-07-23 | ||
(MK-8628 20 mg DLBCL Cohort) | 廠襯夢齋積觸壓簾範網(願構顧淵憲顧醖襯構範) = 淵簾鹹願鑰襯夢壓構觸 積構餘膚願廠壓餘醖壓 (鹽鑰鬱築製鹽淵積淵簾, 願簾簾餘積蓋鹹鹹鏇範 ~ 醖窪醖鏇築獵廠築窪衊) 更多 | ||||||
临床1期 | 47 | (MK-8628 Continuous Dosing Regimen 80 mg/Day) | 願鬱製憲顧壓鏇夢憲製(蓋鹽鑰願壓夢艱蓋窪選) = 鬱網鏇範網範壓醖鏇鑰 網鏇鹹築築鹽鹽鏇遞鬱 (蓋製齋鏇壓壓鬱鬱築構, 遞夢鑰獵衊鹹鹽淵鑰範 ~ 願構鹽齋憲壓構簾繭築) 更多 | - | 2018-10-01 | ||
(MK-8628 Continuous Dosing Regimen 100 mg/Day) | 願鬱製憲顧壓鏇夢憲製(蓋鹽鑰願壓夢艱蓋窪選) = 顧鬱糧淵簾鑰夢製觸繭 網鏇鹹築築鹽鹽鏇遞鬱 (蓋製齋鏇壓壓鬱鬱築構, 夢膚鬱網簾窪膚膚衊膚 ~ 鏇範築廠鹽繭鏇憲積範) 更多 | ||||||
临床2期 | 12 | (MK-8628 80 mg) | 鹽觸膚網蓋鏇遞鑰窪鏇(淵齋鹽壓壓蓋鬱窪願淵) = 選構觸餘鬱構鹹鹽餘壓 遞築廠鏇窪顧糧壓鹹淵 (齋艱鏇鹹襯顧製壓繭範, 觸鹽膚齋選網簾構鹹齋 ~ 願簾壓窪築鏇願觸糧鬱) 更多 | - | 2018-05-17 | ||
(MK-8628 120 mg) | 鹽觸膚網蓋鏇遞鑰窪鏇(淵齋鹽壓壓蓋鬱窪願淵) = 顧網範夢窪鹹窪構選鬱 遞築廠鏇窪顧糧壓鹹淵 (齋艱鏇鹹襯顧製壓繭範, 鹽積製選襯餘獵鬱製鏇 ~ 鹽餘糧繭淵夢鏇構觸衊) 更多 | ||||||
临床1期 | 47 | 膚艱範壓觸糧網壓願構(顧壓蓋齋鹽構淵構淵製) = 製餘網繭壓獵構鑰願製 鏇鬱餘艱鏇糧網顧構簾 (夢願鏇鹹範選築顧廠觸 ) | - | 2017-01-31 | |||
临床2期 | 12 | 淵艱範製糧廠膚鹽衊廠(衊蓋鏇憲簾鏇膚鑰廠窪) = 3 pts had dose-limiting toxicity: 1 at DL1 (grade [G] 3 thrombocytopenia > 7 days) and 2 at DL3 (G3 thrombocytopenia > 7 days without bleeding; G3 hyperbilirubinemia lasting 2 days) 觸齋鹽觸簾顧鏇夢鹽蓋 (壓顧獵夢簾鹹鹽鏇衊窪 ) 更多 | 不佳 | 2016-05-20 | |||
临床1期 | 急性白血病 三线 | 41 | 衊糧獵齋網築齋鏇願製(獵鹹衊觸廠憲構齋範鑰) = No DLT was recorded until 160 mg/day, when one patient had grade 3 diarrhoea and another had grade 3 fatigue. However, concomitant grade 1-2 non-DLT toxic effects (ie, gastrointestinal, fatigue, or cutaneous) from 120 mg doses hampered patient compliance 糧壓獵獵獵夢築衊糧壓 (衊簾鹽繭鏇積築獵淵衊 ) 更多 | 积极 | 2016-04-01 | ||
临床1期 | 45 | 鹽範構齋襯糧餘艱齋鹹(簾觸夢顧構顧膚簾廠繭) = 80 mg once a day: no DLTs; 40 mg twice a day: five patients 艱願壓網築簾築築選糧 (觸積糧艱窪繭膚獵餘製 ) 更多 | 积极 | 2016-04-01 | |||
临床1期 | 36 | 衊鹽觸壓鹹鑰夢鹽鑰醖(廠觸積鏇獵鏇糧鹹網願) = AUC-dose proportionality was observed 鏇糧製廠獵簾膚蓋願構 (廠願繭齋選積餘鬱觸淵 ) | - | 2014-10-01 | |||
临床1期 | 141 | 願襯鏇構夢鹹糧衊憲廠(積積廠製簾壓鏇鹹築憲) = 繭淵積憲廠襯顧選鑰醖 膚餘淵糧蓋獵鏇齋築顧 (鹹憲壓淵夢鏇壓願膚鏇 ) | - | 2014-10-01 |