HP-011-101(HP-011-101) - 药物靶点：Trypsin_在研适应症：褥疮_专利_临床

概要

基本信息

药物类型

生物药

别名

Xenaderm

靶点

Trypsin

作用方式

刺激剂

作用机制

胰蛋白酶刺激剂

治疗领域

皮肤和肌肉骨骼疾病

在研适应症

褥疮

非在研适应症-

原研机构

Smith & Nephew plc

在研机构

Smith & Nephew plc

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与 HP-011-101 相关的临床试验

NCT01433159

/ Terminated临床2期

Comparison of HP011-101 to Standard Care in the Management of Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury

The trial will compare the effects of 14 days treatment with HP011 101 versus Standard Care in subjects with Stage I or II pressure ulcers as a complication of spinal cord injury, measured as change from baseline in composite wound bed scores of the PUSH 3.0 tool.

开始日期2011-09-01

申办/合作机构

HealthPoint

NCT00714519

/ Withdrawn临床2期

A Phase II Feasibility Study of Xenaderm® Ointment Exploring Design Issues for Phase III Efficacy in Partial-Thickness Wounds

This study will assess if a clinical trial regarding healing of partial thickness wounds can be executed in nursing homes.

开始日期2008-07-01

申办/合作机构

HealthPoint

NCT00645164

/ Completed临床1期

Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment

The product is being tested to see if exposure to light causes photoallergic reactions on the skin.

开始日期2008-03-01

申办/合作机构

HealthPoint

100 项与 HP-011-101 相关的临床结果

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100 项与 HP-011-101 相关的转化医学

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100 项与 HP-011-101 相关的专利（医药）

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2

项与 HP-011-101 相关的文献（医药）

2010-02-01·Advances in Skin & Wound Care

Xenaderm

Review

作者: Abraham, Liza Mathais

OBJECTIVETo discuss the clinical efficacy, indications, and application of Xenaderm in wound care management.DATA SOURCESHealthcare literature from Medline and Ovid databases that focus on clinical trials and case studies that used Xenaderm to evaluate duration of wound healing.STUDY SELECTIONInclusion criteria for article selection: (1) articles on clinical trials and case studies in which Xenaderm was the focus of the wound therapy, (2) articles written in English, and (3) articles published later than 2003. Studies that did not meet the inclusion criteria were excluded.CONCLUSIONOutcomes from clinical trials demonstrate that Xenaderm is efficacious and successful in healing wounds twice as fast as saline-treated wounds. Use of Xenaderm is considered safe and cost-effective. Xenaderm is eligible to be included in the wound care management algorithm and is recommended to be used on most partial-thickness wounds. Results from clinical trials show that Xenaderm is an essential topical therapy to facilitate wound healing, decrease hospital financial costs, and improve the quality of life for patients who acquire iatrogenic skin damage.

2004-01-01·Journal of Wound, Ostomy and Continence Nursing3区 · 医学

A Shared Goal for Wound and Continence Care

3区 · 医学

Review

作者: Gray, Mikel

Perineal dermatitis is frequently encountered in patients with urinary and/or fecal incontinence, particularly when managed by a containment device such as a pad or containment brief. In addition to intervening to prevent or alleviate incontinence, a preventive perineal skin program in the high-risk patient and aggressive management of incontinence-related dermatitis are both essential for effective holistic management. A routine cleansing regimen that removes irritants and moisturizes while protecting the skin from additional irritation is effective for prevention of dermatitis and for managing mild cases. However, more aggressive care is required when perineal dermatitis occurs, especially when it is associated with epidermal erosion. Xenaderm ointment combines three active ingredients in a hydrophobic ointment that promotes healing while acting as a moisture barrier to prevent further irritation and damage.

100 项与 HP-011-101 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	D03	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
褥疮	-	Smith & Nephew plc	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01433159 (CTgov)	临床2期	脊髓损伤 \| 褥疮	19	HP011-101 (Xenaderm Ointment)	窪鹹遞衊憲網淵鹽壓壓(構衊鹽鹹餘齋鹽鹹鑰選) = 醖蓋憲鬱糧積淵鹽夢鹹鏇膚糧積選醖願選窪鹽 (廠憲廠築鑰壓願夢顧膚, 糧鏇遞夢築壓選壓糧窪 ~ 觸蓋網壓鏇淵積簾糧蓋) 更多	-	2014-02-10
NCT00645164 (CTgov)	临床1期	-	59	Ointment Vehicle+Xenaderm	夢齋壓淵夢餘繭窪築鹹(醖築鹽獵齋遞淵觸範積) = 壓鹹襯餘獵鬱遞憲繭衊壓襯壓簾鹽襯蓋網觸鏇 (壓積簾鏇顧製願製範衊, 糧範願艱壓簾獵醖鹹選 ~ 繭淵範膚膚範膚餘餘憲) 更多	-	2009-04-06