PF-1163B(PF-1163B) - 药物靶点：MSMO1_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

MSMO1

作用方式

抑制剂

作用机制

MSMO1 inhibitors(methylsterol monooxygenase 1 inhibitors)

治疗领域

感染

在研适应症-

非在研适应症

真菌病

原研机构

Meiji Seika Pharma Ltd.

在研机构-

非在研机构

Waseda UniversityMeiji Seika Pharma Ltd.

权益机构-

最高研发阶段终止临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 PF-1163B 相关的临床结果

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100 项与 PF-1163B 相关的转化医学

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100 项与 PF-1163B 相关的专利（医药）

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3

项与 PF-1163B 相关的文献（医药）

2003-10-01·Organic Letters1区 · 化学

Total Synthesis and Conformational Analysis of the Antifungal Agent (−)-PF1163B

1区 · 化学

Article

作者: Gesson, Jean-Pierre ; Bouazza, Fodil ; Renoux, Brigitte ; Bachmann, Christian

[reaction: see text]. (-)-PF1163B, a new macrocyclic antifungal antibiotic isolated from Streptomyces sp., has been prepared in eight steps from (S)-citronellene. The key step is a ring-closing metathesis reaction of an ester and amide derivative obtained from a substituted N-methyl-l-tyrosine.

2000-01-01·The Journal of Antibiotics4区 · 医学

PF1163A and B, New Antifungal Antibiotics Produced by Penicilium sp. II. Physico-chemical Properties and Structure Elucidation.

4区 · 医学

Article

作者: Satoko Takano ; Yasuo Ohtsuka ; Kuniaki Tatsuta ; Takashi Watanabe ; Takashi Shomura ; Toru Sasaki ; Hiroshi Nose ; Shigemi Yoshida ; Takayuki Usui ; Ayako Hosoya ; Mami Kawaguchi

The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.

1999-01-01·The Journal of Antibiotics4区 · 医学

The Total Synthesis and Absolute Structure of Antifungal Antibiotics (-)-PF 1163A and B.

4区 · 医学

Letter

作者: Satoko Takano ; Kuniaki Tatsuta ; Shojiro Miyazaki ; Yuichi Ikeda ; Satoshi Nakano

The total synthesis of (-)-PF1163A and B (I, R = β-OH, H) from Boc-L-tyrosine and (R)-citronellol was accomplished and their absolute configurations determinedConversion of the protected intermediate from Boc-L-tyrosine with β-naphthoyl chloride to the mixed anhydride followed by reaction of II gave III which after removal of all protecting groups yielded an amino acid which was cyclized by Bop-Cl to give 62% of (-)-PF1163B.(-)-PF1163A was prepared via similar strategy and both were identical to the natural antibiotics in all respects.

100 项与 PF-1163B 相关的药物交易

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