GBD-8

A review.Targeted protein degradation (TPD) represents a promising research field that has quickly attracted attention and efforts from both academia and pharmaceutical industry.In contrast to PROTACs, MG mols. are small-mol.-weight compounds that trigger a compact protein-protein interaction between a target protein and an E3 ubiquitin ligase.However, PROTACs are often relatively large and sometimes suffer from insufficient druggability.In summary, for the first time, we have developed a degrader that targets the BTK and GSPT1 proteins through a unique double mechanism.