Terpinen-4-ol(Terpinen-4-ol) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

感染眼部疾病皮肤和肌肉骨骼疾病+ [1]

在研适应症-

非在研适应症

睑缘炎蠕形螨感染未特指的睑结膜炎

原研机构

Tissue Technologies, Inc.

在研机构-

非在研机构

BioTissue Holdings, Inc.

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Terpinen-4-ol 相关的临床试验

ChiCTR1900025519

/ SuspendedN/AIIT

The efficacy of Terpinen-4-ol Eyelid Scrub Wipes and Okra Eyelid Patch in treating ocular demodex infestation

开始日期2019-09-16

申办/合作机构-

NCT01647217

/ Completed临床1期

Safety and Efficacy of Single-use Terpinen-4-ol Pads for Treating Ocular Mites A Randomized Clinical Trial

This is a randomized clinical trial to determine the safety and efficacy of terpinen-4-ol (T4O), the most active ingredient of tea tree oil (TTO), in eradicating ocular demodicosis (reducing ocular demodex counts and achieving the clinical improvement with minimal or no irritation).

开始日期2014-02-01

申办/合作机构

BioTissue Holdings, Inc.

[+1]

100 项与 Terpinen-4-ol 相关的临床结果

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100 项与 Terpinen-4-ol 相关的转化医学

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100 项与 Terpinen-4-ol 相关的专利（医药）

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393

项与 Terpinen-4-ol 相关的文献（医药）

2025-03-12·Journal of Agricultural and Food Chemistry

Functional Characterization of an Antenna-Biased Odorant Receptor AaOr96 Involved in Tea Tree Oil Repellency Against Aedes aegypti

Article

作者: Chen, Mengli ; Chen, Guoxing ; Chen, Peitong ; Yan, Ru ; Song, Tiefeng ; Tian, Chunxia ; Xu, Zhanyi ; Zhu, Guonian ; Qian, Jiali ; Jin, Yongfeng

Numerous essential oils have been well acknowledged as eco-friendly alternatives to combat insect pests due to synthetic insecticide-induced pest resistance and environment pollution. As a highly commercial essential oil, tea tree oil exhibits excellent insecticidal and repellent activities. However, the molecular mechanism of the olfactory system mediating the tea tree oil-induced repellency against insect pests remains unknown. In our study, mosquito was used as a suitable model to examine the molecular mechanism of tea tree oil-induced repellency against insect pests. The results showed that tea tree oil exhibited excellent spatial and oviposition repellency against Aedes aegypti adults and outstanding repellency against larvae, which were conferred by the main constituent terpinen-4-ol. The reduced repellency in the Orco^-/- mutant strain revealed that tea tree oil-induced repellency against mosquitoes was dependent on odorant receptor(s). Moreover, we identified one antenna-biased odorant receptor, AaOr96, that was involved in detecting constituents of tea tree oil to elicit repellency, and the predicted protein-ligand complex indicated that AaOr96 interacted with terpinen-4-ol via van der Waals forces from five key residues. Finally, knocking out AaOr96 resulted in a reduced spatial repellency against A. aegypti by tea tree oil and terpinen-4-ol, and a reduced oviposition repellency by terpinen-4-ol, but not by tea tree oil. Our study not only reveals that tea tree oil has great potential in pest management but also provides more insights into the molecular basis of repellency of essential oils.

2025-02-01·Food Chemistry

Revealing the off-flavors in hydro-distilled essential oils of sweet orange (Citrus sinensis) by flavoromics strategy and computational simulation

Article

作者: Zhao, Qian ; Deng, Xinping ; Chen, Shiguo ; Zhang, Keer ; Li, Zhongxin ; Chen, Jianle ; Ye, Zhiyue ; Ye, Xingqian ; Wang, Guangnan ; Liu, Mingqi ; Cheng, Huan

Citrus essential oils (EOs) are renowned for their aroma, but thermal extraction methods can introduce undesirable cooking and pungent odors. The specific compounds responsible for these off-flavors and their perception mechanisms remain unclear. This study investigated the flavor differences between cold pressing (CP) and hydro-distilled (HD) extracted essential oils from sweet oranges (SEOs) using flavoromics strategy. The results indicated that increased levels of alcohol compounds, particularly terpinen-4-ol, β-citronellol, geraniol, trans-carveol, and α-terpineol, were primarily responsible for the off-flavors in HD-extracted SEOs. Furthermore, molecular docking and dynamics simulations revealed that off-flavor compounds bind to olfactory receptors through hydrogen bonding and hydrophobic interactions, inducing slight structural and conformational changes that facilitate odor recognition and activate downstream signaling events. This study offers crucial insights into the mechanisms underlying off-flavor development in citrus EOs, providing valuable knowledge for optimizing extraction methods, controlling SEOs quality, and advancing flavor science.

2025-01-01·Heliyon

Antibacterial and antibiofilm activities of kaffir lime essential oils and their active constituents against Staphylococcus aureus focusing on sortase A

Article

作者: Jiamboonsri, Pimsumon ; Pontanayodsakorn, Chayapol ; Eurtivong, Chatchakorn

Staphylococcus aureus biofilm has become a global medical concern due to rising antibiotic resistance. This study aimed to evaluate the potential activities of kaffir lime essential oils and their active compounds as alternative anti-S. aureus biofilm agents. The compositions of the essential oils were identified by gas chromatography/mass spectrometry (GC/MS), and their antibacterial activity was determined through broth-microdilution and time-kill assays. Antibiofilm activities were assessed using Congo red agar (CRA) well diffusion method, pre-biofilm inhibition resazurin assay, and post-biofilm inhibition assay. Sortase A (SrtA) inhibition was also investigated using in silico and in vitro approaches. This is followed by morphological studies to observe change in biofilm formations using light and scanning electron microscopy (SEM). Phytochemical analysis revealed that the kaffir lime essential oils from leaves (KLL) and peels (KLP) were primarily composed of the monoterpene aldehyde citronellal (59.13 %) and the monoterpene hydrocarbon (-)-limonene (25.69 %). However, the monoterpenoid alcohols, β-citronellol and terpinen-4-ol, which were the third most abundant compounds in KLL (5.35 %) and KLP (10.87 %), respectively, were selected for further study. All test compounds exhibited anti-Staphylococcal activity with a minimum inhibitory concentration (MIC) range of 0.1-0.3 % v/v. Their inhibition above the MIC levels showed time- and concentration-independence. Among the test compounds, terpinen-4-ol revealed good antibiofilm activity by inhibiting biofilm formation rather than eradicating the established biofilm. However, terpinen-4-ol exhibited weak SrtA inhibition with docking score of 32.58 and in vitro SrtA inhibition of 46.14 ± 3.58 % at 1 % v/v. Interestingly, terpinen-4-ol caused visible damage to the bacterial cell barrier, as revealed by SEM micrographs. These findings suggest the potential use of kaffir lime oils and their active compounds to combat biofilm-forming S. aureus infection.

100 项与 Terpinen-4-ol 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
未特指的睑结膜炎	临床1期	美国	BioTissue Holdings, Inc.	2014-02-28
睑缘炎	临床1期	美国	BioTissue Holdings, Inc.	2014-02-01
蠕形螨感染	临床1期	美国	BioTissue Holdings, Inc.	2014-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01647217 (DBTS, CTgov)	临床1期	蠕形螨感染 \| 睑缘炎	17	Terpinen-4-ol (Terpinen-4-ol Treatment Arm)	選膚遞鹹淵選窪鑰鏇願(顧觸膚鹹艱壓繭膚獵糧) = 淵獵窪襯膚衊繭蓋壓艱鹹鹹窪襯觸網憲築鑰廠 (鹽淵簾衊積獵範製鬱獵, 鹽壓積壓繭顧淵壓鏇鑰 ~ 餘鹽襯憲衊醖醖襯壓觸) 更多	-	2017-07-26
NCT01647217 (DBTS, CTgov)	临床1期	蠕形螨感染 \| 睑缘炎	17	Placebo (Placepo Pads Contol Arm)	選膚遞鹹淵選窪鑰鏇願(顧觸膚鹹艱壓繭膚獵糧) = 構膚醖艱鹹鬱壓鏇網觸鹹鹹窪襯觸網憲築鑰廠 (鹽淵簾衊積獵範製鬱獵, 鹽窪糧鑰糧餘積鏇範顧 ~ 鏇鬱窪顧製築壓膚齋膚) 更多	-	2017-07-26
UEGW2015	N/A	结直肠癌	-	Terpinen-4-ol	顧繭襯鑰範壓觸選襯簾(憲膚膚餘膚願壓積獵顧) = 膚製選醖壓鹹鹹廠鏇鬱襯範夢範窪醖遞壓鏇觸 (憲餘獵壓鏇鹽餘廠蓋繭 )	积极	2015-10-01