(Terpinen-4-ol) - _专利_临床

概要

基本信息

药物类型

未知

别名-

靶点-

作用机制-

治疗领域

感染眼部疾病皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

睑缘炎蠕形螨感染未特指的睑结膜炎

原研机构

Tissue Technologies, Inc.

在研机构-

非在研机构

TissueTech, Inc.

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

2

项与 Terpinen-4-ol 相关的临床试验

ChiCTR1900025519 / SuspendedN/AIIT

The efficacy of Terpinen-4-ol Eyelid Scrub Wipes and Okra Eyelid Patch in treating ocular demodex infestation

开始日期2019-09-16

申办/合作机构-

NCT01647217 / Completed临床1期

Safety and Efficacy of Single-use Terpinen-4-ol Pads for Treating Ocular Mites A Randomized Clinical Trial

This is a randomized clinical trial to determine the safety and efficacy of terpinen-4-ol (T4O), the most active ingredient of tea tree oil (TTO), in eradicating ocular demodicosis (reducing ocular demodex counts and achieving the clinical improvement with minimal or no irritation).

开始日期2014-02-01

申办/合作机构

TissueTech, Inc.

[+1]

100 项与 Terpinen-4-ol 相关的临床结果

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100 项与 Terpinen-4-ol 相关的转化医学

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100 项与 Terpinen-4-ol 相关的专利（医药）

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408

项与 Terpinen-4-ol 相关的文献（医药）

2024-12-01·Natural Products and Bioprospecting

Disclosing the potential of Cupressus leylandii A.B. Jacks & Dallim, Eucalyptus globulus Labill., Aloysia citrodora Paláu, and Melissa officinalis L. hydrosols as eco-friendly antimicrobial agents

Article

作者: Almeida, Heloísa H S ; Barreiro, Maria-Filomena ; Crugeira, Pedro J L ; Amaral, Joana S ; Rodrigues, Alírio E

AbstractAntimicrobial resistance is a major global health concern, threatening the effective prevention and treatment of infections caused by microorganisms. These factors boosted the study of safe and green alternatives, with hydrosols, the by-products of essential oils extraction, emerging as promising natural antimicrobial agents. In this context, four hydrosols obtained from Cupressus leylandii A.B. Jacks & Dallim, Eucalyptus globulus Labill., Aloysia citrodora Paláu and Melissa officinalis L. were studied. Their chemical composition comprises neral, geranial, 1,8-cineole, terpinen-4-ol, and oplopanonyl acetate, compounds with recognised antimicrobial activity. Concerning antimicrobial activity, significant differences were found using different hydrosol concentrations (10–20% v/v) in comparison to a control (without hydrosol), showing the potential of the tested hydrosols to inhibit the microbial growth of Escherichia coli, Staphylococcus aureus, and Candida albicans. A. citrodora hydrosol was the most effective one, inhibiting 90% of E. coli growth and 80% of C. albicans growth, for both hydrosol concentrations (p < 0.0001). With hydrosol concentration increase, it was possible to observe an improved antimicrobial activity with significant reductions (p < 0.0001). The findings of this work indicate the viability of reusing and valuing the hydrosols, encouraging the development of green applications for different fields (e.g., food, agriculture, pharmaceuticals, and cosmetics).Graphical Abstract

2024-06-01·Food science and technology international = Ciencia y tecnologia de los alimentos internacional

Eradication of multiple-species biofilms from food industrial and domestic surfaces using essential oils.

Article

作者: Vágvölgyi, Csaba ; Kerekes, Erika Beáta ; Takó, Miklós ; Krisch, Judit ; Vidács, Anita

Microbial biofilm formation represents a serious problem for both food industry and households. Natural biofilms are formed mostly by multiple species, and show resistance against most of the usual sanitizers. In this study, the effects of cinnamon (Cinnamomum zeylanicum), marjoram (Origanum majorana) and thyme (Thymus vulgaris) essential oils (EOs) and their main components (cinnamaldehyde, terpinene-4-ol, and thymol) were investigated on four-species biofilms of Escherichia coli, Listeria monocytogenes, Pseudomonas putida and Staphylococcus aureus. Minimum bactericide concentration (MBC) and killing time were determined by means of the microdilution method. MBC of the investigated EOs and components was between 0.5 mg/mL (cinnamaldehyde) to 25 mg/mL (terpinene-4-ol). Killing times for the four-species suspension were 5 or 10 min, time spans usable in the food industry. For eradication of the mixed-population biofilm from stainless steel (SS), polypropylene (PP), tile and wood surfaces, EO- or EO component-based disinfectant solutions were developed, and their effects were compared to a peracetic acid-based industrial sanitizer (HC-DPE). Total eradication of biofilms (99.9%) was achieved, with solutions containing cinnamon and thyme EO and EO components, from SS and PP, but not from tile or wood surfaces. Apparently, cinnamon EO, terpinene-4-ol and thymol have better disinfectant activity than HC-DPE.

2024-04-17·Journal of Agricultural and Food Chemistry

Comparison of Approaches for Authentication of Commercial Terpinen-4-ol-type Tea Tree Oils Using Chiral GC/MS

Article

作者: Linge, Kathryn L ; Downey, Angela ; Cooper, Leif

A global demand for tea tree oil (TTO) has resulted in increased adulteration in commercial products. In this study, we use a novel enantiomeric gas chromatography mass spectrometry method for chiral analysis of key terpenes ((±)-terpinen-4-ol, (±)-α-terpineol, and (±)-limonene) and quantification of components present at >0.01% to test different methods of identifying adulterated TTO. Data from authentic Australian (n = 88) and oxidized (n = 12) TTO samples of known provenance were consistent with recommended ranges in ISO 4730:2017 and previously published enantiomeric ratios, with p-cymene identified as the major marker of TTO oxidation. The 15 ISO 4730:2017 constituents comprised between 84.5 and 89.8% of the total ion chromatogram (TIC) peak area. An additional 53 peaks were detected in all samples (7.3-11.0% of TIC peak area), while an additional 43 peaks were detected in between 0 and 99% (0.15-2.0% of the TIC peak area). Analysis of nine commercial samples demonstrated that comparison to the ISO 4730:2017 standard does not always identify adulterated TTO samples. While statistical analysis of minor components in TTO did identify two commercial samples that differed from authentic TTO, the (+)-enantiomer percentages for limonene, terpinen-4-ol, and α-terpineol provided clearer evidence that these samples were adulterated. Thus, straightforward identification of unadulterated and unoxidized TTO could be based on analysis of appropriate enantiomeric ratios and quantitation of the p-cymene percentage.

100 项与 Terpinen-4-ol 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
蠕形螨感染	临床2期	美国	TissueTech, Inc.	2014-02-01
未特指的睑结膜炎	临床1期	美国	TissueTech, Inc.	2014-02-28
睑缘炎	临床1期	美国	TissueTech, Inc.	2014-02-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01647217 (CTgov)	临床1期	睑缘炎 \| 蠕形螨感染	17	Terpinen-4-ol (Terpinen-4-ol Treatment Arm)	構製淵選蓋製獵簾窪蓋(衊醖夢衊鑰鹽蓋鹹簾繭) = 憲衊製窪齋鬱夢蓋鏇衊夢範網艱齋鑰築淵願築 (夢網衊壓淵餘鬱積製廠, 蓋糧鬱鹽觸簾鹽願艱淵 ~ 淵製艱積糧夢觸壓廠醖) 更多	-	2017-07-26
				Placebo (Placepo Pads Contol Arm)	構製淵選蓋製獵簾窪蓋(衊醖夢衊鑰鹽蓋鹹簾繭) = 艱遞壓顧壓鏇遞選遞醖夢範網艱齋鑰築淵願築 (夢網衊壓淵餘鬱積製廠, 鏇鏇簾蓋顧廠夢範願範 ~ 壓範衊廠艱襯築鹽築廠) 更多