Photodynamic therapy (PDT) is a new therapeutic modality for a variety of skin neoplasms.ATX-S10(Na), 13,17-bis(1-carboxypropionyl)carbamoylethyl-8-ethenyl-2-hydroxy-3-hydroxyiminoethylidene-2,7,12,18-tetra-methylporphyrin sodium salt, is a hydrophilic chlorine photosensitizer, which shows good accumulation in tumors and is rapidly eliminated in the urine within 24-48 h.EC036,13,17-bis(1-carboxyethyl)-3-(1,3-dioxan-2-yl)methylidene-8-ethenyl-2-hydroxy- 2,7,12,18-tetramethylchlorin, di-Me ester, is a novel hydrophobic photosensitizer derived from ATX-S10(Na), with relatively low mol. weight and expected to penetrate more efficiently into the skin compared to ATX-S10(Na).In the present study, the effect of EC036-PDT on 7,12-dimethylbenz[a]anthracene (DMBA) and 12-o-tetradecanoylphorbol-13-acetate (TPA)-induced mouse papillomas was investigated and the anti-tumor effect was compared with that of ATX-S10(Na)-PDT.EC036-PDT using 670 nm diode laser showed potent anti-tumor effects in DMBA and TPA-induced mouse skin tumor model.EC036-PDT might be more useful than ATX-S10(Na)-PDT for the treatment of skin tumors.

2008-02-01·Journal of dermatological science2区 · 医学

ATX-S10(Na)-photodynamic therapy inhibits cytokine secretion and proliferation of lymphocytes

2区 · 医学

Letter

作者: Nakajima, Susumu ; Takahashi, Hidetoshi ; Sakata, Isao ; Ishida-Yamamoto, Akemi ; Iizuka, Hajime

The effect of ATX-S10(Na)-photodynamic therapy (PDT) on the production of cytokines and viability of various T cell lines was investigated.These cell lines include HuT102, MT-2, Jurkat, MoLT4, which are derived from mycosis fungoides, adult T cell leukemia, acute lymphoblastic leukemia and acute lymphoblastic leukemia, resp.It was found that high dose irradiation suppressed cytokine secretion related with reduced cell production however, low dose irradiation suppressed cytokine secretion without the inhibition of cell productionIt was demonstrated that cytokines from lymphocytes such as TNF-α, IFN-γ, IL-6 and IL-8, were suppressed by ATX-S10(Na)-PDT.The results might give an evidence for the novel therapy modality for psoriasis, cutaneous lymphomas and other related skin disorders.

2006-06-01·Nippon Ganka Gakkai zasshi

[Effect of photodynamic therapy with ATX-S 10 (Na) on experimental choroidal neovascularization].

Article

作者: Yuzawa, Mitsuko ; Nakajima, Masami ; Kyou, Tetsuhiro ; Hirose, Tokihito

PURPOSE:

To evaluate an appropriate irradiative condition for selective occlusion of experimental choroidal neovascularization(CNV) with photodynamic therapy (PDT) using ATX-S 10 (Na).

METHODS:

Experimental CNV was induced in monkey eyes by laser photocoagulation. PDT(dose of irradiative energy 40 to 80J/cm2) was performed after 3.5 mg/kg of body weight intravenous injections of ATX-S 10(Na). CNV and retinal vessel occlusion induced by PDT was evaluated by fluorescein angiography (FA) at 1 and 7 days after irradiation. If FA showed no fluorescein dye leakage from CNV at 1 and 7 days after irradiation, CNV was evaluated by histopathological analysis at 7 days after irradiation.

RESULTS:

Within 30 to 33 minutes after ATX-S 10(Na) injection and irradiation with 50 to 60 J/ cm2, FA showed no fluorescein dye leakage from CNV and no closure of retinal vessels at 1 and 7 days after irradiation. Light micrographs showed occluded CNV, and retinal vessels remained patent and there was no apparent change in the inner layer of the retina.

CONCLUSIONS:

Irradiative condition of ATX-S10 (Na) 3.5 mg/kg was appropriate 30 to 33 minutes after ATX-S 10(Na) injection and irradiation with 50 to 60 J/cm2.

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适应症	最高研发状态	国家/地区	公司	日期
滑膜肉瘤	临床前	日本	Photochemical Co. Ltd.	2008-05-09
结肠癌	临床前	日本	Tokyo Medical University	2008-05-01
黑色素瘤	临床前	日本	Tokyo Medical University	2008-05-01
黄斑变性	临床前	美国	-	-
黄斑变性	临床前	日本	-	-
黄斑变性	临床前	欧洲	-	-