乌拉立肽(Ularitide) - 药物靶点：NPR_专利_临床

概要

基本信息

药物类型

合成多肽

别名

Atrial natriuretic factor (95-126)、Atrial natriuretic factor prohormone (95-126)、Ularitide acetate

+ [10]

靶点

NPR

作用方式

激动剂

作用机制

NPR激动剂(心房钠尿肽受体家族激动剂)

治疗领域

感染心血管疾病其他疾病+ [2]

在研适应症-

非在研适应症

急性失代偿性心力衰竭急性肾损伤胡宁病毒感染+ [2]

原研机构

CardioPep Pharma GmbH

在研机构-

非在研机构

Cardiorentis AG

PDL BioPharma, Inc.

权益机构-

最高研发阶段终止临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

Sequence Code 1191632849

来源: *****

关联

9

项与乌拉立肽相关的临床试验

EUCTR2020-004815-29-DE

/ Not yet recruiting临床2期

Open-label, dose escalation study of ularitide for the investigation of hemodynamic effects in patients with pulmonary arterial hypertension (UPAH)

开始日期2021-08-04

申办/合作机构

Cardiorentis AG

NCT04311489

/ Terminated临床2期IIT

Single-center, Randomized, Double-blind, Placebo-controlled Clinical Trial for the Safety, Tolerability and Efficacy of Ularitide in Cirrhosis Patients With Refractory Ascites.

This clinical trial intends to investigate the safety, tolerability and efficacy of ularitide on the renal response in patients with liver cirrhosis and refractory ascites for a maximum exposure duration of 48 hours, through a randomized, placebo-controlled, double-blind, single-center trial.

开始日期2020-08-01

申办/合作机构

University of Aarhus

[+1]

EUCTR2018-004871-11-DE

/ Unknown status临床2期

RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED DOSE ESCALATION STUDY OF ULARITIDE FOLLOWED BY A 42-HOUR INFUSION FOR THE TREATMENT OF ACUTE KIDNEY INJURY (AKI) IN PATIENTS POST CARDIAC SURGERY - TRUST

开始日期2019-09-05

申办/合作机构

Cardiorentis AG

100 项与乌拉立肽相关的临床结果

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100 项与乌拉立肽相关的转化医学

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100 项与乌拉立肽相关的专利（医药）

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400

项与乌拉立肽相关的文献（医药）

2025-05-01·Clinical Transplantation

(Pro)renin, Erythropoietin, Vitamin D and Urodilatin Release From Human Donor Kidneys During Normothermic Machine Perfusion: Predictors of Early Post‐Transplant Outcome?

Article

作者: Lin, Hui ; Danser, A. H. Jan ; Fang, Yitian ; Cristoferi, Iacopo ; Garrelds, Ingrid M. ; Bousnina, Karim ; Minnee, Robert C. ; Slagter, Julia S. ; Hoogduijn, Martin J. ; Reinders, Marlies E. J.

ABSTRACTBackgroundHuman donor kidneys release (pro)renin, erythropoietin (EPO), active vitamin D, and urodilatin during normothermic machine perfusion (NMP). However, whether the endocrine function of donor kidneys is associated with post‐transplant kidney function is unclear.MethodsWe studied 28 donor kidneys, including seven from donation after brain death (DBD) donors and 21 from donation after circulatory death (DCD) donors. Prior to transplantation, we measured levels of (pro)renin, EPO, 1,25(OH)2D in the perfusate, and urodilatin in urine during NMP. Hormone release rates were compared between kidneys with and without delayed graft function (DGF), and correlations were assessed between hormone release rates and donor characteristics and transplant outcome, including DGF duration, serum creatinine levels at 1‐week post‐transplant, and estimated glomerular filtration rate at 1‐month post‐transplant.ResultsDBD kidneys secreted significantly less EPO and more active vitamin D than DCD kidneys. Kidneys with DGF exhibited significantly higher release rates of active vitamin D and lower release rates of urodilatin compared to those without DGF. In addition, EPO release rate was positively correlated with serum creatinine levels at 1‐week post‐transplant. Finally, urodilatin release rates were negatively correlated with DGF duration and positively correlated with urine output.ConclusionsUrodilatin release in urine and EPO and active vitamin D release in perfusate during NMP may serve as potential biomarkers for predicting early post‐transplant outcomes.Trial Registration: ClinicalTrials.gov identifier: NCT04882254

2024-03-29·Cureus

New Pharmacotherapeutic Classes for the Management of Heart Failure: A Narrative Review

Review

作者: Sangwan, Arushi ; Haryani, Abhishek

Heart failure (HF) is a syndrome characterized by the heart failing to pump blood to the body at a rate proportional to its needs. HF is a public health burden globally and one of the leading causes of hospitalizations in adults. While many classes of drugs have been introduced for the treatment of HF, not every drug may be well-tolerated by patients. In this narrative review, we describe a few of the newer classes of medications proposed to be efficacious in treating acute and chronic HF. We focus on vericiguat, omecamtiv mecarbil, ularitide, and serelaxin, and thoroughly examine their efficacy and safety profiles while summarizing the clinical trials of the drugs. There is a need for more long-term studies comparing the efficacy of these medications to the conventional ones.

2021-11-12·Danish medical journal4区 · 医学

Ularitide as treatment of refractory ascites in cirrhosis- a study protocol for a randomised trial.

4区 · 医学

Article

作者: Meyer, Markus ; Watson, Hugh ; Holzmeister, Johannes ; Aagaard, Niels Kristian ; Grønbæk, Henning ; Gantzel, Rasmus Hvidbjerg ; Jepsen, Peter ; Mazgareanu, Stefan

INTRODUCTION Ascites is a frequent complication to cirrhosis. When ascites becomes refractory to standard diuretic pharmacotherapy, patients are facing a median survival of less than one year and most likely a need for frequent hospitalisations due to large-volume paracentesis or complications. An unmet need exists for new and improved treatments of refractory ascites and the present study investigates the potential of the natriuretic peptide ularitide for this indication. METHODS We aim to investigate the effects, safety and tolerability of ularitide as treatment of refractory ascites in cirrhosis patients in a randomised, double-blind, placebo-controlled trial. Participants receive ularitide or placebo as a continuous intravenous infusion during hospitalisation as an add-on to any diuretic treatment. Clinical end points include increase in diuresis and natriuresis, reduction in body weight and waist circumference, safety end points, as well as changes in plasma concentrations of renal and systemic response biomarkers and hormones. CONCLUSION This study will provide evidence concerning the potential of ularitide in treating cirrhosis patients with refractory ascites. FUNDING This investigator-initiated trial is supported by ADS AIPHIA Development Services AG. TRIAL REGISTRATION Clinicaltrials.gov (NCT04311489) and EU Drug Regulating Authorities Clinical Trials (EudraCT: 2019-002268-28). The trial will be conducted in accordance with good clinical practice, the Declaration of Helsinki and applicable demands from Danish authorities.

1

项与乌拉立肽相关的新闻（医药）

2024-03-02

·PRNewswire

Global Acute Heart Failure (AHF) Therapeutics Research Report 2022-2024 and 2030: Conventional Therapies Leave Considerable Unmet Needs, Novel Treatments Offer a Ray of Hope

DUBLIN, March 1, 2024 /PRNewswire/ -- The "Acute Heart Failure (AHF) Therapeutics: Global Strategic Business Report" report has been added to ResearchAndMarkets.com's offering. Global Acute Heart Failure (AHF) Therapeutics Market to Reach $2.9 Billion by 2030 The global market for Acute Heart Failure (AHF) Therapeutics estimated at US$599.7 Million in the year 2022, is projected to reach a revised size of US$2.9 Billion by 2030, growing at a CAGR of 21.7% over the analysis period 2022-2030. Cardiac Glycosides, one of the segments analyzed in the report, is projected to record a 22.3% CAGR and reach US$762.4 Million by the end of the analysis period. Taking into account the ongoing post pandemic recovery, growth in the B-Blockers segment is readjusted to a revised 25.1% CAGR for the next 8-year period. The acute heart failure (AHF) market has been significantly impacted by the COVID-19 pandemic and the looming global recession. Despite the challenges, diuretics and vasodilators remain the first-line therapy for AHF, although the efficacy of other known drugs for AHF is limited, hindering their widespread use. Market insights and trajectories indicate a complex landscape influenced by these factors, with varying degrees of competitive market presence among players worldwide in 2022. Recent market activity reflects ongoing efforts to size the AHF market and adapt to the evolving healthcare landscape. Looking ahead, the market outlook suggests continued focus on addressing the challenges posed by COVID-19 and economic uncertainties while exploring opportunities for innovation and growth in AHF therapeutics. The U.S. Market is Estimated at $163.4 Million, While China is Forecast to Grow at 30.4% CAGR The Acute Heart Failure (AHF) Therapeutics market in the U.S. is estimated at US$163.4 Million in the year 2022. China, the world's second largest economy, is forecast to reach a projected market size of US$841.2 Million by the year 2030 trailing a CAGR of 30.4% over the analysis period 2022 to 2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 16.3% and 18.4% respectively over the 2022-2030 period. Within Europe, Germany is forecast to grow at approximately 17.1% CAGR. Led by countries such as Australia, India, and South Korea, the market in Asia-Pacific is forecast to reach US$433.4 Million by the year 2030. MARKET OVERVIEW Influencer Market Insights World Market Trajectories Market Outlook Recent Market Activity Sizing the AHF Market Acute Heart Failure - An Overview of the Disease and Available Therapeutics Diuretics and Vasodilators - The First Line Therapy for AHF Other Known Drugs for AHF - Lower Efficacy Thwarts Use Acute Heart Failure (AHF) Therapeutics - Global Key Competitors Percentage Market Share in 2022 (E) Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2022 (E) Impact of Covid-19 and a Looming Global Recession MARKET TRENDS & DRIVERS Conventional Therapies Leave Considerable Unmet Needs Novel Treatments Offer a Ray of Hope Key AHF Therapeutics in the Pipeline Serelaxin Nears Trial Readout form RELAX-AHF-2 Ularitide - A Novel Drug in Development for AHF The Litany of Drug Failures Expands, Emphasis on Prevention Grows Other Promising Drugs under Development Research Findings Kidney Dysfunction - Predictor of Acute Heart failure Genetic Influence on Heart Disease among African Americans Higher Body Mass Index - A Key Risk Factor for AHF Supplemental Oxygen Therapy May not be for All Cases of AHF Macro Growth Drivers Alarming Levels of Cardiovascular Disease (CVD) Prevalence: Key Growth Driver for AHF Therapeutics Ballooning Elderly Population: The Vital Growth Driver for AHF Therapeutics FOCUS ON SELECT PLAYERS (Total 93 Featured) Bayer AG (Germany) Bristol-Myers Squibb Company (USA) Cardiorentis AG (Switzerland) CVie Therapeutics Limited (Taiwan) Cytokinetics, Inc. (USA) Merck & Co. (USA) Novartis AG (Switzerland) Orion Corporation (Finland) PhaseBio Pharmaceuticals, Inc. (USA) For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets

AHA会议

100 项与乌拉立肽相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	乌拉立肽	-	DB05034

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
急性失代偿性心力衰竭	临床3期	美国	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	波兰	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	爱沙尼亚	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	比利时	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	法国	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	意大利	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	土耳其	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	罗马尼亚	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	芬兰	Cardiorentis AG	2012-07-01
急性失代偿性心力衰竭	临床3期	匈牙利	Cardiorentis AG	2012-07-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01661634 (TRUE-AHF, Pubmed \| N Engl J Med) 人工标引	临床3期	心脏衰竭	2,157	Ularitide	(鏇窪獵觸蓋遞願鑰鬱鹹) = 廠窪積網遞構齋鬱範觸鑰襯範鹹餘鬱築鬱鹹餘 (齋廠顧餘憲願襯積膚鹽 )	积极	2017-05-18
				Placebo	(鏇窪獵觸蓋遞願鑰鬱鹹) = 淵範構觸壓顧餘襯廠製鑰襯範鹹餘鬱築鬱鹹餘 (齋廠顧餘憲願襯積膚鹽 )