作者: Yulia S. Korobovtseva ; Larisa V. Mikhina ; Alla V. Tretyakova ; Roman V. Borovick ; Arkadyi V. Ivanov ; Alexander A. Denisov ; Konstantin M. Salmakov ; Olga M. Karpova

In a series of studies in SPF and conventional guinea pigs, various adjuvants (larifan, polyoxidonium-PO, natrium thiosulphate-NT, TNF-β and Ribi adjuvant system-RAS) were evaluated for their ability to enhance immune responses to the live brucellosis vaccine, Brucella abortus strain 82-PS (penicillin-sensitive). Combining adjuvants with S82-PS increased synthesis of antibodies against rough (R) and smooth (S) Brucella antigens. Dynamics and levels of antibodies differed dependent upon the adjuvant. Adjuvants enhanced cell-mediated responses to S82-PS, and phagocytosis by macrophages. Humoral and cellular immune responses stimulated by the adjuvants correlated with increased vaccine protection against experimental challenge. The highest protection was demonstrated by combining TNF-β or PO with S82-PS. Our data demonstrates the potential of adjuvants to improve immunogenic properties of live brucellosis vaccines.

1980-11-01·Biulleten' eksperimental'noi biologii i meditsiny

[Effect of Brucella abortus on growth of ovarian granulosa cell carcinoma].

Article

作者: Litvinkova, N P ; Trubcheninova, L P ; Baryshnikov, A Iu

Live brucellosis vaccine Brucella abortus administered intraperitoneally, intravenously, subcutaneously or into the tumorous node inhibits the growth of granular cell ovarian carcinoma OC-1-72. The inhibitory effect depends on the B. abortus dose and tumor size. Pretreatment with B. abortus led, in some experiments, to the stimulation of tumor growth. The similar action was demonstrated by killed B. abortus vaccine administered into the tumorous node. The inhibitory effect on tumor growth can be mediated through the peritoneal exudate cells and spleen cells. Serum and an extract from spleens of mice infected with B. abortus inhibit the development of Rauscher's viral leukemia.

1978-09-01·Gigiena i sanitariia

O vliianii pestitsidov na immunologicheskuiu reaktivnost' organizma zhivotnogo i cheloveka.

Article

作者: Safarova, A A ; Brysin, V G ; Babaiants, R A ; Klots, V I

100 项与布氏菌活疫苗 (兰州生物制品研究所) 相关的药物交易

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