OBJECTIVETo evaluate the anti-ovulatory activity of H(2) receptor blockers (ranitidine, famotidine and roxatidine) in albino rabbits considering the role of histamine in ovulation.METHODThe drugs were orally administered once daily for three days to adult female rabbits weighing between 1.3-2.0 kg (four groups of three animals). The control group received the 1% weight/volume gum acacia suspension. Thirty minutes after the administration of the last dose, a freshly prepared 0.4 % solution of cupric acetate was administered to each animal intravenously via the marginal ear vein (4 mg/kg body weight) to induce ovulation. To assess ovulation, laparotomy was carried out 48 h after cupric acetate injection. The ovaries were exposed, bleeding points on each ovary were counted, and the ovaries and uteri were subjected to histopathological evaluation.RESULTSBased on the number of bleeding points (ovulation sites) observed on the ovary, H(2) blockers showed varying degrees of anti-ovulatory activity. Roxatidine exerted the most pronounced activity. Histopathological observations of uterus and ovary confirmed the aforementioned observations.CONCLUSIONH(2) receptor blockers appeared to inhibit the cupric acetate-induced ovulation in albino rabbits. Our results seem to confirm the role of histamine in ovulation reported by other authors.

2010-10-01·JDDG: Journal der Deutschen Dermatologischen Gesellschaft3区 · 医学

Allergic contact dermatitis caused by the blue pigment VINAMON® Blue BX FW – a Phthalocyanine Blue in a vinyl glove

3区 · 医学

Article

作者: Swen Malte John ; Christoph Skudlik ; Stefanie Weimann

SummaryA 44‐year‐old metalworker suffered from severe hand eczema in spite of treatment with corticosteroid ointments. He had been using protective cotton gloves with blue PVC anti‐slip dots on the finger tips. On clinical examination, the backs of both hands were erythematous and thickened while the finger tips showed vesicles. There was a positive patch test reaction to the blue PVC dots of an unworn cotton glove at 72, 96, 120 hours. To identify the causative chemicals, we carried out further patch tests using ingredients of the glove and cupric sulfate. The patient reacted to the blue dye VYNAMON® Blue BX FW (PB 15) at two concentrations – 10% at 72 and 96 hours, and 50% at 48 and 72 hours. This dye is a very strong and brilliant blue with red‐copper tones and resistant to fire and weathering. The cupric‐phthalocyanine complexes are used as pigments in cosmetics (e. g. CI 74160, 74180, 74260). To the best of our knowledge, no allergic reactions to this dye have been described, particularly not in gloves.

2009-12-01·BMC Complementary and Alternative Medicine

Anti-microbial activities of pomegranate rind extracts: enhancement by cupric sulphate against clinical isolates of S. aureus, MRSA and PVL positive CA-MSSA

Article

作者: Alison F Kelly ; Mark D Fielder ; Simon W J Gould ; Declan P Naughton

AbstractBackgroundRecently, natural products have been evaluated as sources of antimicrobial agents with efficacies against a variety of micro-organisms.MethodsThis report describes the antimicrobial activities of pomegranate rind extract (PRE) singularly and in combination with cupric sulphate against methicillin-sensitive and -resistant Staphylococcus aureus (MSSA, MRSA respectively), and Panton-Valentine Leukocidin positive community acquired MSSA (PVL positive CA-MSSA).ResultsPRE alone showed limited efficacy against MRSA and MSSA strains. Exposure to copper (II) ions alone for 2 hours resulted in moderate activity of between 102 to 103 log10 cfu mL-1 reduction in growth. This was enhanced by the addition of PRE to 104 log10 cfu mL-1 reduction in growth being observed in 80% of the isolates. However, the PVL positive CA-MSSA strains were more sensitive to copper (II) ions which exhibited moderate activities of between 103 log10 cfu mL-1 reduction in growth for 60% of the isolates.ConclusionPRE, in combination with Cu(II) ions, was seen to exhibit moderate antimicrobial effects against clinical isolates of MSSA, MRSA and PVL positive CA-MSSA isolates. The results of this study indicate that further investigation into the active ingredients of natural products, their mode of action and potential synergism with other antimicrobial agents is warranted. This is the first report of the efficacy of pomegranate against clinical PVL positive CA-MSSA isolates.

100 项与硫酸铜相关的药物交易

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