(Iodofiltic acid I-123) - 在研适应症：诊断试剂_专利_临床

概要

基本信息

药物类型

小分子化药、诊断用放射药物

别名

15-(4-Iodophenyl)-3(R,S)-Methylpentadecanoic Acid (123I)、IPPA、Iodofiltic Acid I 123

+ [4]

靶点-

作用机制

SPECT(单光子发射计算机断层成像术增强剂)

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Nihon Medi-Physics Co., Ltd.

非在研机构

Pfizer Inc.

最高研发阶段批准上市

首次获批日期

日本 (1993-01-19),

诊断试剂

最高研发阶段(中国)-

特殊审评-

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结构

分子式C22H35IO2

InChIKeyNPCIWINHUDIWAV-NSYCNWAXSA-N

CAS号123748-56-1

关联

3

项与 Iodofiltic acid I-123 相关的临床试验

JPRN-UMIN000027712 / CompletedIIT

Validation study of 3D-thoracic duct scintigraphy by orally administered 123I BMIPP with healthy subjects. - Validation study of 3D-thoracic duct scintigraphy

开始日期-

申办/合作机构

Tohoku University

JPRN-UMIN000029768 / SuspendedIIT

A pilot study to establish simultaneous acquisition of 99m-Tc and 123-I-BMIPP tracers using SPECT with CZT detectors - A pilot study to establish simultaneous acquisition of 99m-Tc and 123-I-BMIPP tracers using SPECT with CZT detectors

开始日期2017-11-06

申办/合作机构-

NCT00514501 / Completed临床2期

Open-label, Phase 2 Study of the Safety and Efficacy of B-methyl-P-(123I)- Iodophenyl-pentadecanoic Acid (Iodofiltic Acid I 123) For Identification of Ischemic Myocardium Using Single Photon Emission Computed Tomography (Spect) in Adults With Symptoms Consistent With Acute Coronary Syndrome (ACS).

This is an open-label phase 2 study recruiting low, moderate, and high likelihood ACS patients from approximately 60 centers. Patients will be imaged with iodofiltic acid I 123 for the detection of myocardial ischemia. Readers independent of the clinical study centers will review results of imaging studies in a blinded fashion at an imaging core lab. The resulting independent reading of the images will be compared against the truth standard for ACS.

开始日期2007-05-01

申办/合作机构

Molecular Insight Pharmaceuticals, Inc.

100 项与 Iodofiltic acid I-123 相关的临床结果

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100 项与 Iodofiltic acid I-123 相关的转化医学

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100 项与 Iodofiltic acid I-123 相关的专利（医药）

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164

项与 Iodofiltic acid I-123 相关的文献（医药）

2024-01-01·Annals of Nuclear Medicine

Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images

Article

作者: Kawahito, Michitomo ; Nakajima, Kenichi ; Miyauchi, Hideyuki ; Kudo, Takashi ; Fujimoto, Shinichiro ; Iimori, Takashi ; Hirano, Ken-Ichi

AbstractThe purpose of this practice recommendation is to specifically identify the critical steps involved in performing and interpreting 123I-β-methyl-iodophenyl-pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT) and measurement of washout rate (WR) from the heart. This document will cover backgrounds, patient preparation, testing procedure, visual image interpretation, quantitation methods using planar and SPECT studies, and reporting of WR. The pitfall and some tips for the calculation of 123I-BMIPP WR are also included. The targets of global and regional WR calculation include ischemic heart disease, cardiomyopathy, heart failure, and triglyceride deposit cardiomyovasculopathy, an emerging rare heart disease.

2024-01-01·Annals of Nuclear Medicine

Correction: Practice recommendation for measuring washout rates in 123I-BMIPP fatty acid images

作者: Kawahito, Michitomo ; Nakajima, Kenichi ; Miyauchi, Hideyuki ; Kudo, Takashi ; Fujimoto, Shinichiro ; Iimori, Takashi ; Hirano, Ken-Ichi

2022-11-01·Journal of Interpersonal Violence2区 · 心理学

Exploring Insecure Romantic Attachment and Justifications for the Use of Intimate Partner Psychological Aggression in Couples

2区 · 心理学

Article

作者: Brassard, Audrey ; Lafontaine, Marie-France ; Péloquin, Katherine ; Leclerc, Marie-Eve

The attachment theory has commonly been used to examine intimate partner psychological aggression (IPPA), but few studies have examined its association with self-reported justifications for one’s own use of IPPA. Behaviors, including the use of IPPA, are influenced, maintained, and function within the context of their justifications, highlighting the importance of investigating these justifications to obtain a clearer picture of IPPA. This study examined whether insecure romantic attachment (i.e., attachment anxiety and attachment avoidance) in both partners of a couple was associated with their justifications for their own use of IPPA. A community sample of 81 mixed-sex couples who reported using IPPA in the last year completed self-reported questionnaires on adult romantic attachment and their justifications for their use of IPPA. Results of a path analysis based on the actor-partner interdependence model revealed moderate positive associations between attachment anxiety and one’s use of internal and external justifications for their IPPA perpetration in men and women. An unexpected dyadic positive association is discussed. These results suggest that the use of justifications for one’s use of IPPA may reflect a strategy of hyperactivation that could contribute to the cycle of psychological aggression. Uncovering the function of these justifications could provide important therapeutic benefits, which are discussed in the study’s implications.

100 项与 Iodofiltic acid I-123 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB05683

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
诊断试剂	日本	Nihon Medi-Physics Co., Ltd.	1993-01-19

未上市

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适应症	最高研发状态	国家/地区	公司	日期
诊断试剂	临床3期	-	Pfizer Inc.	-
冠心病	药物发现	-	Pfizer Inc.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00514501 (Zeus-ACS, Pubmed \| J Am Coll Cardiol)	临床2期	急性冠状动脉综合征	507	Iodofiltic acid I 123 (BMIPP) (BMIPP)	(遞鏇觸餘艱鏇醖範範餘) = 餘繭觸窪齋鏇膚醖鬱夢醖齋顧憲衊憲鹹獵壓廠 (觸範艱構夢範淵餘廠淵 ) 更多	-	2010-07-20
NCT00514501 (CTgov)	临床2期	急性冠状动脉综合征	510	Iodofiltic acid I 123	(膚窪廠醖艱餘廠窪淵製) = 鏇選製廠醖鬱網廠網範廠鏇襯衊襯齋構積衊築 (膚積鑰顧構糧膚窪築簾, 鬱遞淵範製繭廠顧蓋觸 ~ 簾製鏇壓壓積鏇窪觸衊) 更多	-	2016-01-25