阿扎司特(Acitazanolast Hydrate) - 在研适应症：季节性过敏性结膜炎_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Acitazanolast、Acitazanolast hydrate (JAN)、MTCC

+ [4]

靶点-

作用机制

组胺释放抑制剂、白三烯释放抑制剂

治疗领域

免疫系统疾病眼部疾病

在研适应症

季节性过敏性结膜炎

非在研适应症-

原研机构

Wakamoto Pharmaceutical Co., Ltd.

在研机构

Kowa Co., Ltd.

Wakamoto Pharmaceutical Co., Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2000-09-22),

季节性过敏性结膜炎

最高研发阶段(中国)-

特殊审评-

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结构

分子式C9H7N5O3

InChIKeyVWQZJJZGISNFOE-UHFFFAOYSA-N

CAS号114607-46-4

关联

6

项与阿扎司特相关的临床试验

CTRI/2023/03/051167 / Completed临床2期

A Prospective, Interventional, Randomized, Parallel, Double blind, Multicenter, Placebo controlled, Clinical Study to evaluate the efficacy and safety of Bacillus Coagulans BCP92 (MTCC 25460) in adults with irritable bowel syndrome.

开始日期2023-04-10

申办/合作机构

Pellucid Lifesciences Pvt Ltd.

CTRI/2023/01/048914 / Not yet recruiting临床4期

A Randomized, Double-Blind, Placebo-Controlled, Two-arm, Parallel Study to Evaluate Clinical Safety of Heat Inactivated Bacillus coagulans (Weizmannia coagulans) MTCC 5856 (Sami-Sabinsa Group Limited, India) in Healthy Human Participants.

开始日期2023-01-16

申办/合作机构

Sami-Sabinsa Group Ltd.

CTRI/2022/06/043239 / RecruitingN/A

A randomized, double-blind, placebo-controlled study to evaluate efficacy and safety of Bacillus coagulans MTCC 5856 in management of acute diarrhea in children

开始日期2022-07-30

申办/合作机构

Sami-Sabinsa Group Ltd.

100 项与阿扎司特相关的临床结果

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100 项与阿扎司特相关的转化医学

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100 项与阿扎司特相关的专利（医药）

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11

项与阿扎司特相关的文献（医药）

2022-07-29·European Journal of Psychotraumatology

Effectiveness of a nurse-led Mindfulness-based Tai Chi Chuan (MTCC) program on Posttraumatic Growth and perceived stress and anxiety of breast cancer survivors

Article

作者: Zhang, Jia-Yuan ; Zhou, Yu-Qiu ; Li, Sha-Sha ; Meng, Li-Na

研究背景: 随着积极心理学的发展, 关于癌症患者创伤后生长的研究越来越受到研究者的关注。有效提高癌症患者创伤后生长水平, 提高其生活质量具有重要意义研究目的: 探讨护士主导的正念太极 (MTCC) 计划对乳腺癌幸存者创伤后成长 (PTG)、感知压力和焦虑的有效性研究方法: 本研究进行了RCT设计。参与者被随机分配到MTCC组或对照组。59名患有I -III期乳腺癌的妇女参加了项目。干预组接受护士指导的8周, 每周2次, 每次1小时的正念训练计划。采用经验证的PTG量表 (PTGI)、感知压力量表 (PSS) 和焦虑自评量表(SAS), 分干预前 (T1)、干预后 (T2) 和干预1年后 (T3) 三次测量干预效果。采用重复测量方差分析模型对数据进行分析研究结果: MTCC组干预8周及随访后PTG水平明显高于对照组 (F= 374.98, P< .000)。MTCC可提高PTG水平, 且干预1年后效果持续。此外, PSS (F = 55.22, P< .000) 和SAS (F = 148.92, P< .000) 评分在T2和T3时显著降低.

2022-06-01·Aesthetic Plastic Surgery4区 · 医学

Comparison of Free Diced and Multiple Toothpick-Shaped Costal Cartilage Injection Techniques for Augmentation Rhinoplasty

4区 · 医学

Article

作者: Li, Xin ; Yang, Xiaoning ; Yu, Lu ; Gu, Tianyi ; Ma, Jiguang

BACKGROUNDThe free diced costal cartilage (FDCC) injection technique has been used in the augmentation rhinoplasty for a long time. In order to lower the incidence of nasal contour irregularities and graft displacement, we developed the multiple toothpick-shaped costal cartilage (MTCC) injection technique. This comparative study was conducted to introduce and assess this new technique.METHODSThis retrospective analysis included 51 patients who underwent augmentation rhinoplasty with either the FDCC or MTCC injection technique at the 17th Department of Plastic Surgery in the Plastic Surgery Hospital between July 2014 and May 2020. The patients were divided into the FDCC (n = 30, 58.82%) and MTCC (n = 21, 41.18%) groups. General data, postoperative patient satisfaction, complications and revision rate were compared between the groups.RESULTSExcept for the follow-up period, there were no significant differences in general data (age, sex, preoperative dorsum deformity, preoperative rhinoplasty history) between the groups. Postoperative patient satisfaction, complications and revision rate were similar between the two groups.CONCLUSIONSThe MTCC injection is a safe and effective technique for augmentation rhinoplasty. Like the FDCC injection technique, the new technique is relatively easy to perform and time-saving with concealed scarring and minimal postoperative edema. Most of its revision surgeries are also easy to perform by simple rasping and reinjection. According to our experience, the new technique may have wider indication as well as lower incidence of nasal contour irregularities and graft displacement. Therefore, we suggest that the MTCC injection technique is reliable and worthy of recommendation.LEVEL OF EVIDENCE IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

2011-01-01·Journal of Oleo Science4区 · 农林科学

In Vitro Assessment of the Cytotoxicity of Anti-allergic Eye Drops Using 5 Cultured Corneal and Conjunctival Cell Lines

4区 · 农林科学

Article

作者: Masahiko Ayaki ; Shigeo Yaguchi ; Atsuo Iwasawa ; Ryohei Koide

The aim of this study was to evaluate the cytotoxicity of anti-allergic eye drops for human corneal endothelial cells (HCEC) and commercially available ocular surface cells. A primary HCEC culture was derived from human eye bank specimens. SIRC (rabbit corneal epithelium), BCE C/D-1b (bovine corneal epithelial cells), RC-1 (rabbit corneal epithelium), and Chang (human conjunctival cells) were obtained commercially. The WST-1 assay was used to measure HCEC viability, and the viability of other cells was measured using the MTT assay. Cells were treated with 7 commercially available anti-allergic eye drops for 48 h and cell viability was measured and calculated as a percentage of control. The degree of toxicity for each eye-drop solution was based on the cell viability score (CVS). HCECs treated with a 1000-fold dilution of the eye-drop solution had a viability score of 67% for Rizaben and ≥80% for the other solutions with Zepelin being the least toxic. Cell viability in response to eye-drop solutions preserved with benzalkonium chloride (BAK) was dependent on the concentration of the drug solution and exposure time. Treatment of ocular surface cells with a 20-fold dilution of the eye-drop solution resulted in the following order of cell viability as determined by their CVS: Zepelin > Ketas = Zaditen ≥ Tramelas PF = Patanol ≥ Rizaben ≥ Livostin. This order was similar to that observed for HCECs, and cell viability was found to be concentration-dependent. Based on the penetration of the drug into eye tissues, HCECs are only likely to be pharmaceutically damaging in rare cases. Epithelial cell viability depends primarily on the concentration of BAK rather than on the action of the active component in the eye-drop solution. CVS values were useful for comparison of toxicity.

100 项与阿扎司特相关的药物交易

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