茄子皮提取物(Eggplant peel extract)

概要

基本信息

药物类型

中药

别名

Brinjal peel extract、Brinjal peel extract containing cream、Solanum melongena peel extract

靶点-

作用机制-

治疗领域

皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

砷性角化病

原研机构

Bangabandhu Sheikh Mujib Medical University

在研机构-

非在研机构

Bangabandhu Sheikh Mujib Medical University

最高研发阶段无进展临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与茄子皮提取物相关的临床试验

NCT03641079 / Unknown status临床2期IIT

Identification of Compound From Brinjal Peel Extract That is Effective in the Treatment of Severe Palmar Arsenical Keratosis and Bowen's Disease

Arsenicosis is a major health problem in Bangladesh. Long term exposure of arsenic causes keratosis of palm which reduce working capacity of patient. It also causes invasive skin lesions like Bowen's disease which has a risk to develop squamous cell carcinoma. Brinjal peel is well known for its antioxidant and anticancer properties. So this study will be conducted to identify the compound from brinjal peel extract and to see its outcome on keratosis and Bowen's disease.

开始日期2017-09-16

申办/合作机构

Bangabandhu Sheikh Mujib Medical University

NCT03127670 / Completed临床2期IIT

Effect of Solanum Melongena Extract in the Treatment of Arsenical Skin Lesion

Solanum melongena is a common vegetable contains phytochemicals which prevent, reduce or delay the oxidation of DNA and alter the cellular signal transduction pathways controlling cell proliferation and apoptosis of human cancer. The skin of Solanum melongena peel contains nasunin an anthocyanins and chlorogenic acid which have anti-inflammatory, antioxidant, antimutagenic and antiangiogenic properties. Extract of Solanum melongena is used in actinic keratosis and Squamous cell carcinoma of the skin. This study will determine any change in arsenical skin lesion after administrating Solanum melongena extract cream.

开始日期2016-11-14

申办/合作机构

Bangabandhu Sheikh Mujib Medical University

100 项与茄子皮提取物相关的临床结果

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100 项与茄子皮提取物相关的转化医学

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100 项与茄子皮提取物相关的专利（医药）

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10

项与茄子皮提取物相关的文献（医药）

2023-06-01·Heliyon

Determination of imidacloprid in brinjal and okra fruits, decontamination and its dietary risk assessment

Article

作者: Naik R, Harischandra ; N, Saroja Rao ; V, Sangamesh ; M, Saraswati ; A, Prabhuraj ; M, Paramasivam ; M S, Pallavi ; M, Bheemanna ; Hosamani, Arunkumar ; K, Pavankumar ; Ratnamma

Brinjal and okra are being sprayed withdifferent formulations of imidacloprid which leads to significant deposition of residues on fruits. Here in this study, we validated a method that could detect the traces of imidacloprid residues in a short run time using LC-MS/MS. LOD of 0.001 and LOQ of 0.003 μg/g for brinjal and in compliance with the MRL (0.2 mg/kg). The recovery at different spiking levels recorded 89.67 to 115.55 with an RSDr range of 3.02 and 5.22%. For okra, 0.0025 and 0.008 μg/g were observed as LOD and LOQ, respectively. Recovery was obtained between 88.69 and 93.74%. Precision in terms of repeatability (RSD_r) and reproducibility (RSD_wR) was found satisfactory in both matrices. Two applications of imidacloprid 17.8% SL in both vegetables showed faster dissipation initially and persisted up to 15-25 days. Decontamination with 2% salt solution followed by boiling for 15min. removed 96.43 and 73.66% of imidacloprid residues from brinjal and okra, respectively. Risk assessment was found to be less than one (HI < 1) for brinjal and okra matrix and can be safely consumed.

2022-12-01·Environmental Geochemistry and Health3区 · 环境科学与生态学

Human health exposure and risks of arsenic from contaminated soils and brinjal fruits collected from different producers and retailers levels

3区 · 环境科学与生态学

Article

作者: Sharmin, Shaila ; Zakir, H M ; Bushra, Anika ; Quadir, Q F ; Sarker, Aniruddha ; Rashid, M H ; Rahman, A

A quantitative assessment was attempted to determine concentrations of total arsenic (As) in farmer's field soils and fruits of brinjal collected from two famous brinjals producing Upazila's, namely Melandaha and Islampur of Jamalpur district, Bangladesh. The study also evaluated cancer and non-cancer health risks for both males and females caused by dermal exposure of soils and dietary intake of brinjal grown in farmers' fields and sold at different markets of four country districts. The study findings revealed that 75% of soil sampling locations had enrichment factor (EFc) values > 1.5, indicating the anthropogenic sources of As, and 50% of the sites possessed EFc values within the range of 2.0-5.0 indicated moderate enrichment of As. The mean concentrations of As in brinjal grown in farmers' fields and retailers of different markets of four districts were 0.18 and 0.39 µg g^-1, respectively. The soils of the study area exhibited negligible risk in terms of the calculated hazard quotient, hazard index and incremental lifetiame cancer risk (ILCR) values for As due to dermal and ingestion exposures. In contrast, the same values for As due to the dietary intake of brinjal were thousands of times greater than the threshold level in 40% of farmers' field and all retailers' levels samples. Compared to the producer/farmers' field samples, the calculated average non-carcinogenic and carcinogenic health risks were more than twice in samples collected from different retailers. The present study suggests further pinpoint investigation of potential entry routes of As in the supply chain through future traceability studies.

2017-11-01·Pakistan journal of pharmaceutical sciences4区 · 医学

Total antioxidant capacity of commonly used fruits, vegetables, herbs and spices of Pakistan.

4区 · 医学

Article

作者: Sharif, Muhammad Junaid Hassan ; Mahmood, Wajahat ; Abid, Mobasher Ali ; Khan, Ikarmullah ; Rauf, Khalid ; Ashfaq, Muhammad ; Abbas, Ghulam

The current study was aimed at investigating the total antioxidant activity (TAC) of various fruits, vegetables, herbs and spices habitat in Pakistan. The ferric reducing ability of plasma (FRAP) assay was used to measure the TAC of various extracts (aqueous, ethanolic and aqueous-ethanolic). Following is the potency order for fruits (guava >strawberry >Pomegranate >apple >kinnow >melon >lemon >banana), vegetables (spinach >Cabbage (Purple) >Jalapeno >Radish >Brinjal >Bell Pepper >Lettuce >Carrot >Cabbage (White) >Onion >Potato >Tomato >Cucumber) and herbs/spices (clove >Rosemary >Thyme >Oregano >Cinnamon >Cumin >Kalonji >Paprika >Neem (Flower) >Fennel >Black Cardamom >Turmeric >Coriander >Ginger >Garlic). In conclusion, the guava, spinach and clove provide the best natural dietary option for treatment / prevention of oxidative stress and thus could alleviate several associated ailments.

100 项与茄子皮提取物相关的药物交易

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