Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech)(Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech))

概要

基本信息

药物类型

预防性疫苗、多价疫苗

别名-

靶点-

作用方式

刺激剂

作用机制

免疫刺激剂

治疗领域

感染呼吸系统疾病

在研适应症-

非在研适应症

流感病毒感染

原研机构

Folia Biotech, Inc.

在研机构-

非在研机构

Folia Biotech, Inc.

权益机构-

最高研发阶段无进展临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的临床试验

JPRN-jRCTs041230032

/ Recruiting临床1期IIT

Safety study of Plasma-activated Lactate Ringer's Solution (PAL) for application on human normal skin - Safety study of PAL for application on human skin

开始日期2023-06-08

申办/合作机构-

NCT02188810

/ Unknown status临床1期

A Phase I Randomized, Observer-blind, Controlled, Dose Escalation Trial of the Safety and Tolerability of a Single Intramuscular Dose of a PAL Adjuvant (FB-631) Co-administered With Seasonal TIV (2013-2014) in Healthy Adults.

This is a phase 1, research study is looking at the safety and acceptability of a new vaccine adjuvant (immune booster) called PAL when combined with the seasonal flu vaccine (Fluviral) to test the safety and effectiveness of new vaccines and medications on healthy volunteers.
The study will enroll approximately 48 healthy adult participants, and occur over 3 years. In the first six months/180 days of the study participants will have visits to the study site during which safety and immunogenicity outcomes will be measured. From Day 181 to Year 3, participants will be contacted by telephone or email to collect information on any adverse events.

开始日期2014-04-01

申办/合作机构

Folia Biotech, Inc.

100 项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的临床结果

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100 项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的转化医学

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100 项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的专利（医药）

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491

项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的文献（医药）

2025-04-01·Journal of Applied Microbiology

Weakened fungus-assisted remediation of Cd(II) after addition of fibrous palygorskite

Article

作者: Chen, Jiani ; Xu, Meiyue ; Li, Xuefei ; Wu, Sijia ; Yu'an Li ; Li, Zhen ; He, Yuxin ; Weng, Haoyang ; Han, Feiyu ; Xian, Mengjun

AbstractAimsRhodotorula mucilaginosa (Rho) has a strong ability to absorb heavy metals. In this study, the influences of fibrous palygorskite (Pal) on fungus-assisted remediation of Cd2+ was investigated.Methods and resultsThree sets of treatments were performed, i.e. Cd@Rho, Cd@Pal, and Cd@Rho + Pal. R. mucilaginosa removed Cd2+ via its extracellular polymeric substances and intracellular accumulation. The high sorption helped the fungus to resist the Cd2+ stress up to 200 mg l−1. In addition, the removal rate reached 17% at 50 mg l−1 level. In contrast, the sorption of Cd2+ by palygorskite was significantly lower (0.3%) than that of R. mucilaginosa. In the treatments of Cd@Rho + Pal, the removal rate declined from 24% to 5% when Cd2+ level increased from 50 to 100 mg l−1. This was attributed to the fact that palygorskite particles adhered to the cell surface, occupying adsorption sites for Cd2+. Although the Cd density on each cell declined, the cells showed limited relief due to the relatively high toxicity of Cd2+. Meanwhile, the P removal content also declined after addition of palygorskite. Moreover, the content of tryptophan and carotenoids, which can substantially resist heavy metal stress, were not significantly increased.ConclusionsTherefore, the addition of fibrous palygorskite had an overall negative influence on fungus-assisted Cd remediation.

2025-03-21·Medicine

Mechanistic insights into the anticancer effects of Pinellia ternata (Thunb.) Ten. ex Breitenb. and Ligusticum chuanxiong Hort. ex S. H. Qiu & al. on papillary thyroid carcinoma: A network pharmacology approach

Article

作者: Wang, Gang ; Kong, Xiangding ; Wang, Kuanyu ; Chen, Jing

This study aims to elucidate the mechanisms of action of Pinellia ternata (Thunb.) Ten. ex Breitenb. and Ligusticum chuanxiong Hort. ex S. H. Qiu & al. (PAL) in treating papillary thyroid carcinoma (PTC) using bioinformatics and network analysis. Compounds in PAL were identified from the HERB database. Potential herbal targets were predicted using the SwissADME and SwissTargetPrediction platforms. Differential expression genes related to PTC were extracted from the GEO database and protein–protein interaction networks were constructed using the String database and Cytoscape software. Additionally, gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted, and core compound-target interactions were validated through molecular docking. Effective components identified included 32 from Pinellia ternata (Thunb.) Ten. ex Breitenb. and 105 from Ligusticum chuanxiong Hort. ex S. H. Qiu & al., comprising 825 targets. A total of 2155 differential expression genes related to PTC were selected using GEO2R software, with 71 therapeutic targets identified. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses suggest that PAL may exert effects through cancer-related pathways and signal transduction processes. Molecular docking indicated high binding affinity between several compounds and their targets. Specific active components in PAL may act through various mechanisms on PTC, offering scientific bases for further drug development and treatment strategies.

2025-03-01·Journal of Hazardous Materials

Potential ecological risk of microplastics contamination to environment in protect area lakes

Article

作者: Honghui, Lin ; Zao, Yang ; Xin, Liu ; Xintong, Mei ; Bo, Zhong ; Yixin, He ; Naying, Li ; Xiaofeng, Wang

Microplastics (MPs) in freshwater have been extensively studied on a global scale. However, a deeper understanding is still required regarding the occurrence characteristics and ecological risks of MPs in protected area lakes(PAL). Here, the study investigated MPs pollution in PAL, outside protected areas lakes (OPAL), and ponds (OPAP) in the eastern Qinghai-Tibetan Plateau, and a comprehensive analysis was conducted comparing lakes or ponds from different income regions. The results showed that PAL has a single source of contamination, while OPAL and OPAP exhibited more diverse MP sources. The surface of all samples showed significant physicochemical changes like oxygen-containing functional groups and potential signs of biodegradation. Microbiome analysis identified potential plastic-degrading bacteria on MPs, which varied by polymer type. Ecological risk assessment revealed that OPAL and OPAP face higher ecological risks, particularly from polymers like PVC and PC, while PAL has low risk. However, we should also consider the environmental changes over the past 100 years of history in this region and emphasize the environmental health of PAL. Notably, MPs pollution is more severe in lower-middle-income regions, highlighting the urgent need for stricter controls.

100 项与 Trivalent influenza vaccine adjuvanted with PAL(Folia Biotech) 相关的药物交易

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