芪术糖肾颗粒(Qizhu Sugar Kidney Granules) - 在研适应症：糖尿病肾病_专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

内分泌与代谢疾病泌尿生殖系统疾病

在研适应症

糖尿病肾病

非在研适应症-

原研机构

中国中医科学院西苑医院

在研机构

中国中医科学院西苑医院

非在研机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)临床2期

特殊审评-

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关联

1

项与芪术糖肾颗粒相关的临床试验

CTR20220074 / Recruiting临床2期IIT

芪术糖肾颗粒治疗糖尿病肾脏疾病（气阴两虚证）的有效性和安全性的随机、双盲、安慰剂平行对照、多中心Ⅱa期临床试验

初步探索芪术糖肾颗粒治疗糖尿病肾脏疾病（气阴两虚证）的有效性和安全性

开始日期2022-01-12

申办/合作机构

中国中医科学院西苑医院

100 项与芪术糖肾颗粒相关的临床结果

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100 项与芪术糖肾颗粒相关的转化医学

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100 项与芪术糖肾颗粒相关的专利（医药）

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1

项与芪术糖肾颗粒相关的文献（医药）

2001-01-01·Biological and Pharmaceutical Bulletin4区 · 医学

Antioxidant Potential of Qizhu Tang, a Chinese Herbal Medicine, and the Effect on Cerebral Oxidative Damage after Ischemia Reperfusion in Rats.

4区 · 医学

Article

作者: XUEJIANG, Wang ; ICHIKAWA, Haruyo ; KONISHI, Tetsuya

A traditional Chinese herbal medicine, Qizhu Tang (QZT) was studied for its in vitro antioxidant activity and the effect on cerebral oxidative damage after forebrain ischemia followed by reperfusion in rats. The QZT decoction was shown to have strong hydroxyl radical (*OH) scavenging activity (approx. 0.1 mM as Trolox equivalent) when determined by ESR using DMPO as a spin trap reagent and H2O2/UV as the *OH source. When the QZT decoction was injected into rat duodenum 2 h before cerebral ischemia, the oxidative brain damage after 45 min reperfusion was strongly inhibited in terms of two biochemical indications, thiobarbituric acid reactive substance formation and the loss of glutathione peroxidase. Since the QZT formula consists of 4 herbal constituents (Rhizoma atractylodis, Poria, Radix notoginseng and Radix astragali), each of the component herbs and their combinations were also examined for their protective effects on the cerebral ischemia/reperfusion injury and the effects were compared with their in vitro antioxidant potential. Although some of the incomplete formulas showed as strong antioxidant activities as complete QZT in vitro, only the complete QZT formula was effective in preventing cerebral oxidative injury in rats, and other preparations showed limited activity in vivo.

100 项与芪术糖肾颗粒相关的药物交易

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