The effect of 1,2,4-triazole and its nitro derivatives on the formation of final mol. products of radiation-induced transformations of oxygen-saturated ethanol has been studied.It has been found that the test compounds are almost not decomposed in the course of radiolysis, whereas they insignificantly decrease or do not affect the radiation-chem. yields of H₂O₂ and acetaldehyde.The exptl. data indicate that the nitro derivatives of 1,2,4-triazole cannot compete with oxygen for α-hydroxyethyl radicals, and they do not interact with oxygen-centered radicals formed in the system.The reaction rate constant of the oxidation of α-hydroxyethyl radicals by the nitro derivatives of 1,2,4-triazole was found to be k ≤ 4.6 x 10⁹ L mol^-1 s^-1 by calculation using the method of competing reactions.

2019-08-01·Chemistry and Physics of Lipids3区 · 生物学

Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol

3区 · 生物学

Article

作者: Samovich, Svetlana N ; Shadyro, Oleg I ; Sladkova, Anastasia A ; Sverdlov, Roman L ; Edimecheva, Irina P

Effects of quinones and azoles on the formation of steady-state radiolysis products in aqueous solutions of glycerol-1-phosphate and aqueous dispersions of 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol has been investigated. The data obtained by LC-MS-ESI and spectrophotometric measurements shows that the compounds having quinoid structures, including the antitumor agent doxorubicin, and azoles having nitro groups effectively inhibit free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol, decreasing the radiation-chemical yields of either inorganic phosphate or phosphatidic acid respectively. The observed effects of blocking free-radical processes are believed to be related to the ability of the tested compounds to oxidize α-hydroxyl-containing carbon-centered radicals of starting substrates, which give rise to fragmentation reaction. The possibility of using the discovered properties of quinones, doxorubicin and nitroazoles to provide practical solutions in oncological radiotherapy and pathophysiology is discussed.

2019-03-01·High Energy Chemistry

Interaction of 1,2,4-Triazole Nitro Derivatives with α-Hydroxyethyl Radicals: A Steady-State Radiolysis Study

作者: O. A. Ivashkevich ; I. A. Kapusto ; Yu. V. Grigor’ev ; A. Ya. Maliborskii ; R. L. Sverdlov ; S. D. Brinkevich ; O. I. Shadyro

A series of 1,2,4-triazole nitro and dinitro derivatives has been synthesized.The interaction of the obtained compounds with carbon-centered radicals formed during the radiolysis of deaerated ethanol was studied by the steady-state radiolysis method.It has been established that 1,2,4-triazole slightly changes the ratio of the radiation-chem. yields of deaerated ethanol radiolysis products in favor of acetaldehyde, while the nitro derivatives of this nitrogen-containing heterocyclic compound quant. oxidize α-hydroxyethyl radicals.It was shown that the introduction of the second nitro group into the 1,2,4-triazole cycle does not result in substantial changes in the efficiency of the interaction of the tested substances with α-hydroxyethyl radicals.A mechanism has been proposed for the formation of the identified by liquid chromatog.-mass spectrometry final mol. products of the radiation-induced transformations of the radiation sensitizer Sanazol in deaerated ethanol.

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