AD-70(AD-70) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

ADM OXD、ADM-OXD、DOX OXD

+ [4]

靶点-

作用方式-

作用机制-

治疗领域

肿瘤血液及淋巴系统疾病

在研适应症-

非在研适应症

血液肿瘤肿瘤

原研机构

Mitsubishi Tanabe Pharma Corp.

在研机构-

非在研机构

Mitsubishi Tanabe Pharma Corp.Mitsubishi Pharma Corp.

最高研发阶段终止临床1期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

1

项与 AD-70 相关的临床试验

NCT00733616

/ Completed临床2期IIT

Phase II Study of Adjusted-dose Docetaxel-oxaliplatin-capecitabine in Patients With Advanced Gastric Adenocarcinoma and Intermediate General Status.

The purpose of the study is to determine efficacy and safety of combination therapy with adjusted-dose docetaxel-oxaliplatin-capecitabine in patients with advanced gastric adenocarcinoma and intermediate general status.(defined as ECOG 2 or weight loss 10-25% or older that 70 years and no comorbidities nor functional dependency nor geriatric syndrome)

开始日期2008-11-01

申办/合作机构

Hoffmann-La Roche, Inc.

[+1]

100 项与 AD-70 相关的临床结果

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100 项与 AD-70 相关的转化医学

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100 项与 AD-70 相关的专利（医药）

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12

项与 AD-70 相关的文献（医药）

2011-01-01·Immunological Investigations3区 · 医学

Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) Modulates Immune Responses toAspergillus fumigatusDuring Fungal Asthma in Mice

3区 · 医学

Article

作者: Xing, Zhou ; Choi, Esther S. ; Ramaprakash, Hemanth ; Hartl, Dominik ; Murray, Lynne A. ; Buckland, Karen F. ; Aoki, Naoko ; Hogaboam, Cory M. ; Carpenter, Kristin J. ; Lukacs, Nicholas W. ; Kunkel, Steven L.

Triggering receptor expressed on myeloid cells-1 (TREM-1) expression is increased during pulmonary fungal infection suggesting that this receptor might be involved in anti-fungal immune responses. To address the role of TREM-1 in a murine model of fungal allergic airway disease, A. fumigatus-sensitized CBA/J mice received by intratracheal injection a mixture of live A. fumigatus conidia and one of a control adenovirus vector (Ad70), an adenovirus containing a gene encoding for the extracellular domain of mouse TREM-1 and the F(c) portion of human IgG (AdTREM-1Ig; a soluble inhibitor of TREM-1 function), or an adenovirus containing mouse DAP12 (AdDAP12; DAP12 is an intracellular adaptor protein required for TREM-1 signaling), and examined at various days after challenge. Whole lung TREM-1 levels peaked at day 3 whereas circulating TREM-1 levels peaked at day 30 in this fungal asthma model. AdTREM-1Ig-treated mice exhibited significantly higher airway hyperresponsiveness following methacholine challenge compared with Ad70- and AdDAP12-treated mice. Whole lung analysis of AdTREM-1Ig treated mice revealed markedly higher amounts of fungal material compared with the other groups. ELISA analysis of whole lung and bronchoalveolar lavage samples indicated that several pro-allergic cytokine and chemokines including CCL17 and CCL22 were significantly increased in the AdTREM-1Ig group compared with the other groups. Finally, Pam3Cys and soluble Aspergillus antigens induced TREM-1 transcript expression in macrophages in a TLR2 dependent manner. In conclusion, TREM-1 modulates the immune response directed against A. fumigatus during experimental fungal asthma.

2009-06-01·International Journal of Pharmaceutics2区 · 医学

A smart flower-like polymeric micelle for pH-triggered anticancer drug release

2区 · 医学

Article

作者: Eun Seong Lee ; Kyung Taek Oh ; Don Haeng Lee ; Young Taik Oh ; Kwangmyung Kim ; Nam-Muk Oh

Novel pH-responsive flower-like micelles were developed to provide the mechanism for pH-triggered drug release from drug carriers. The micelles (particle size: approximately 165 nm; critical micelle concentration (CMC): approximately 4 microg/ml), constructed from poly(N(epsilon)-(3-diethylamino)propyl isothiocyanato-L-lysine)-b-poly(ethylene glycol)-b-poly(L-lactide) [poly(DEAP-Lys)-b-PEG-b-PLLA], were designed to have a self-assembled flower-like arrangement consisting of two hydrophobic blocks [deprotonated poly(DEAP-Lys) block and PLLA block] and a petal-like hydrophilic PEG block at physiological pH. As the pH decreases to slightly acidic pH (

2006-09-26·ChemInform

Synthesis, Physicochemical Characterization and Preliminary Pharmacological in vitro Evaluation of Two Novel Cytotoxic Benzophenone‐Linked 3,3‐Dimethyltriazenes.

Article

作者: G Momekov ; I Manolov ; H J Machulla

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

100 项与 AD-70 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
血液肿瘤	临床1期	-	Mitsubishi Tanabe Pharma Corp.	-
肿瘤	临床1期	日本	Mitsubishi Pharma Corp.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO_GU2021	N/A	肾细胞癌	16	Gemcitabine plus doxorubicin (Gem + Dox)	襯積襯蓋壓廠壓衊願選(襯築製艱鹽廠膚觸選鹹) = no grade ≥ 2 reported events of cardiotoxicity 範壓膚鬱餘顧淵簾膚鹹 (齋遞顧醖糧構淵艱廠遞 ) 更多	-	2021-03-02
ASCO_GI2020	N/A	腺癌	28	Perioperative DOX	(淵膚糧顧壓壓鏇選窪膚) = 餘鬱鏇選選衊積壓糧範繭願繭積構鹽鬱築築壓 (觸憲顧繭襯齋製積淵構 )	积极	2020-02-04
AACR2015	N/A	乳腺癌	-	DOX-lipid conjugate	鑰願窪遞蓋簾繭範鬱憲(壓夢衊襯遞蓋醖簾衊醖) = 襯齋築夢鏇範積範餘衊廠製遞願窪範醖鑰鑰壓 (鹹襯窪窪製餘鬱鏇範繭 )	-	2015-08-01
ASCO2015	N/A	肉瘤一线	41	Metastatic STS patients receiving single agent dox.	憲鹽願鬱構夢艱糧壓襯(淵淵憲鹽膚膚觸淵觸憲) = 構廠選廠衊淵憲範顧構膚積廠鬱積襯壓鹹獵簾 (淵獵齋鏇齋蓋壓顧獵餘 )	-	2015-05-20
ASCO2015	N/A	骨肉瘤	26	CP and DOX	(襯壓積醖鏇選鬱鏇願觸) = 獵築齋繭廠淵構艱觸糧鑰膚糧鹽遞窪膚積選壓 (淵願願製構衊鹽膚願醖 ) 更多	-	2015-05-20
ASCO2015	N/A	骨肉瘤	26	CP, DOX, and HDM	(襯壓積醖鏇選鬱鏇願觸) = 積夢簾餘餘衊選簾繭衊鑰膚糧鹽遞窪膚積選壓 (淵願願製構衊鹽膚願醖 ) 更多	-	2015-05-20
ASCO2005	临床2/3期	肝细胞癌	339	T138067 250 mg/m2	(醖積壓積壓範簾淵範範) = 獵願餘餘襯鏇簾淵憲鹹鏇糧蓋齋壓窪範顧獵願 (遞醖構觸夢願齋鹽範衊 )	不佳	2005-06-01
ASCO2005	临床2/3期	肝细胞癌	339	DOX 60 mg/m2	(醖積壓積壓範簾淵範範) = 製顧齋鹹鏇範醖簾廠選鏇糧蓋齋壓窪範顧獵願 (遞醖構觸夢願齋鹽範衊 )	不佳	2005-06-01