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更新于：2025-05-07

Cyanidin-3-glucoside

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名-

靶点

Reactive oxygen species

作用方式

抑制剂

作用机制

活性氧抑制剂

治疗领域-

在研适应症-

非在研适应症-

原研机构

Catholic University of Korea

在研机构

Catholic University of Korea

非在研机构-

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Cyanidin-3-glucoside 相关的临床结果

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100 项与 Cyanidin-3-glucoside 相关的转化医学

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100 项与 Cyanidin-3-glucoside 相关的专利（医药）

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203

项与 Cyanidin-3-glucoside 相关的文献（医药）

2025-05-01·Food Research International

Cyanidin-3-glucoside improves cognitive impairment in naturally aging mice by modulating the gut microbiota and activating the ERK/CREB/BDNF pathway

Article

作者: Wang, Yong ; Hao, Yanling ; Fang, Wei ; Chen, Yuyu ; Song, Ge ; Qi, Wentao ; Peng, Wenting

Aging-related cognitive impairment has emerged as a major health-threatening factor among the elderly, and cyanidin-3-glucoside (C3G) is a prominent anthocyanin with biological activities, including antioxidant, anti-inflammatory, and alleviation of neurodegeneration. However, the role of C3G in alleviating natural aging-induced cognitive impairment and the underlying mechanisms thereof remain unclear. In this study, experimental methods mainly included biochemical analysis, pathological analysis, immunofluorescence staining, transmission electron microscopy analysis, western blot, as well as the determination of the gut microbiota composition and detection of metabolites. We found that C3G may exert neuroprotective effects and promote brain health by alleviating brain atrophy and neuroinflammation, enhancing brain antioxidant capacity, regulating neurotransmitter expression and hypothalamic-pituitary-adrenal axis activity, and attenuating blood-brain barrier and hippocampal synaptic damage. Furthermore, C3G also promotes gut health by decreasing inflammatory responses and intestinal tissue crypt damage, upregulating the expression of tight junction proteins, and attenuating intestinal damage. Notably, C3G regulated the microbiota composition in different intestinal segments and intestinal mucosa, as well as the metabolic homeostasis of gut microbiota metabolites, such as short-chain fatty acids (SCFAs), amino acids, and bile acids. Substantially increased levels of SCFAs could activate the extracellular signal-regulated kinase (ERK)/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway by acting on the G protein-coupled receptors. Correlation analysis indicated that increased gut microbiota, such as Faecalibaculum and Bifidobacterium, and elevated SCFAs were positively correlated with behavioral improvement and brain health. In conclusion, our findings reveal that C3G has the potential to improve natural aging-induced cognitive impairment by modulating the gut microbiota and its metabolite SCFAs, thereby activating the ERK/CREB/BDNF pathway.

2025-05-01·Animal Reproduction Science

Effect of the simultaneous addition of cyanidin 3-glucoside and cyanidin 3-rutinoside in boar semen preserved under refrigeration at 17°C for 168 hours

Article

作者: Tonon, Renata Valeriano ; Dos Santos Gomes, Flávia ; Pedrosa, Ana Carolina ; Nieto, Rosa Daniela Palchucan ; Martins, Simone Maria Massami Kitamura ; de Andrade, André Furugen Cesar ; da Silva, Guilherme Ferreira ; Cabral, Lourdes Maria Corrêa ; Pradiee, Jorgea ; Zapparoli, Henricco

Artificial insemination is widely used in swine reproductive management, allowing a single high-genetic-value male to fertilize a larger number of females. However, the dilution of spermatozoa in cooling media does not prevent oxidative processes that reduce the fertilizing capacity of sperm cells. This study investigated the effects of the antioxidant compounds cyanidin 3-glucoside and cyanidin 3-rutinoside, present in açaí extract, on sperm motility and the integrity of the plasma and acrosomal membranes of boar spermatozoa cooled to 17 ºC for up to 168 hours and the impact of these compounds on preventing the formation of superoxide anions. Semen samples were diluted with different concentrations of these compounds and compared with a long-term extender (Vitasem®) and a negative control. The results were evaluated at three time points: initial (time 0), after 96 hours, and after 168 hours of cooling. Vitasem® maintained high levels of motility and sperm plasma membrane integrity, while the cyanidins did not provide significant improvements compared to the negative control. Statistical analysis indicated that the addition of cyanidin 3-glucoside and cyanidin 3-rutinoside at the tested concentrations did not result in significant improvements in sperm characteristics. These findings suggest the need to explore other concentrations and combinations of antioxidants to optimize sperm preservation during cold storage.

2025-04-23·Journal of Agricultural and Food Chemistry

Alleviation Effect of the Secondary Metabolite of Anthocyanin (Protocatechuic Acid) on Heterocyclic Amine (IQ)-Induced Liver Injury and Its Underlying Mechanism

Article

作者: Zhao, Yanan ; Cao, Ran ; Chen, Lei ; Deng, Hongting ; Chen, Leyao ; Liu, Jiang ; Teng, Hui

Increased consumption of thermally processed meats caused a high risk of accumulation of heterocyclic amines (HCAs), which would lead to livery injuries and carcinogenic diseases in daily life. Our previous study found that cyanidin-3-glucoside expressed a protective effect on 2-amino-3-methylimidazo [4,5-f] quinoline (IQ)-induced liver injury, but its intrinsic mechanism in vivo was unclear. Thus, this study was aimed at investigating the alleviation effect of the secondary metabolite of anthocyanin (protocatechuic acid) on IQ-induced liver dysfunction and its underlying mechanism. The results demonstrated that 4 weeks of IQ (30 mg/kg) administration to C57BL/6 mice induced significant oxidative stress and liver injury, which were suppressed by PCA (10 and 20 mg/kg) supplement. Meanwhile, IQ-mediated liver inflammation was mitigated by PCA supplementation via suppressing NF-κB/MAPK pathways of signaling. Moreover, the PCA supplement significantly reversed IQ-induced intestinal damage and tight junction dysfunction. Concurrently, 16s rRNA sequencing data indicated by PCA reversed the IQ-disturbed SCFAs content and gut microbiota. Analysis of the correlation between intestinal damage and gut microbiota, with manufacturers of hepatic dysfunction, underscored the significance of the gut-liver axis in PCA-relieved liver injury stimulated via IQ. Taken together, PCA reduced IQ-induced liver damage via modifying the NF-κB/MAPK-NLRP3 inflammatory cascade, which was controlled by intestinal barrier failure mediated by the gut microbiota. In summary, our results offer new perspectives on microbiome-targeted therapeutic strategies for liver dysfunction associated with IQ.

100 项与 Cyanidin-3-glucoside 相关的药物交易

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