β-Tocotrienol(β-Tocotrienol) - 药物靶点：RHOA_在研适应症：哮喘_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

RHOA

作用机制

RHOA抑制剂(ras homolog family member A inhibitors)

治疗领域

免疫系统疾病呼吸系统疾病

在研适应症

哮喘

非在研适应症-

原研机构-

在研机构

Tottori University

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 β-Tocotrienol 相关的临床结果

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100 项与 β-Tocotrienol 相关的转化医学

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100 项与 β-Tocotrienol 相关的专利（医药）

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1

项与 β-Tocotrienol 相关的文献（医药）

2003-01-01·Neuroscience Letters4区 · 医学

Vitamin E isoforms α-tocotrienol and γ-tocopherol prevent cerebral infarction in mice

4区 · 医学

Article

作者: Kazuhisa Matsunaga ; Kenichi Mishima ; Takamitsu Tanaka ; Yoshiharu Karube ; Nobuaki Egashira ; Jiro Takata ; Katsunori Iwasaki ; Fengling Pu ; Michihiro Fujiwara ; Ryoji Hidaka

Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.

100 项与 β-Tocotrienol 相关的药物交易

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