ZY22(ZY22) - _专利_临床

概要

基本信息

药物类型

活菌制剂

别名

靶点-

作用机制

细菌替代物、微生物调节剂

治疗领域-

在研适应症-

非在研适应症-

原研机构

广州知易生物科技有限公司

在研机构-

非在研机构

广州知易生物科技有限公司

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)终止

特殊审评-

关联

100 项与 ZY22 相关的临床结果

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100 项与 ZY22 相关的转化医学

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100 项与 ZY22 相关的专利（医药）

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1

项与 ZY22 相关的文献（医药）

2009-09-01·Steroids4区 · 医学

Polyhydroxylated steroids from an endophytic fungus, Chaetomium globosum ZY-22 isolated from Ginkgo biloba

4区 · 医学

Article

作者: Ming-Sheng Bai ; Ya-Mei Zhang ; Sheng-Xiang Yang ; Ya-Tuan Ma ; Jian-Chun Qin ; Hartmut Laatsch ; Jin-Ming Gao

A novel polyhydroxylated C(29)-sterol, 25xi-methyl-22-homo-5alpha-cholest-7,22-diene-3beta,6beta,9alpha-triol, designated globosterol (1), together with one known tetrahydroxylated ergosterol (22E, 24R)-ergosta-7,22-diene-3beta,5alpha,6beta,9alpha-tetraol (2) has been isolated from the cultures of an endophytic fungus, Chaetomium globosum ZY-22 originated from the plant Ginkgo biloba. The structures and relative configurations of 1 and 2 were established on the basis of extensive spectroscopic analyses including 1D and 2D NMR ((1)H-(1)H COSY, HSQC, HMBC, and NOESY) experiments and comparison with the literature. Globosterol (1) possesses an unprecedented 25-methyl Delta(22)-C(10)-side chain and Delta(7)-3beta,6beta,9alpha-hydroxy-steroid nucleus, which represents the first example for C(29)-steroids of the group.

100 项与 ZY22 相关的药物交易

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