Vac-CRT/E7 (Johns Hopkins University)(Vac-CRT/E7 (Johns Hopkins University)) - 药物靶点：CALR x HPV E7_专利_临床

概要

基本信息

药物类型

DNA疫苗、治疗性疫苗

别名-

靶点

CALR x HPV E7

作用机制

CALR刺激剂(calreticulin stimulants)、E7基因刺激剂(人乳头瘤病毒E7基因刺激剂)

治疗领域

肿瘤泌尿生殖系统疾病

在研适应症-

非在研适应症

宫颈癌

原研机构

The Johns Hopkins University

在研机构-

非在研机构

The Johns Hopkins University

Johns Hopkins Technology Ventures

最高研发阶段无进展药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Vac-CRT/E7 (Johns Hopkins University) 相关的临床结果

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100 项与 Vac-CRT/E7 (Johns Hopkins University) 相关的转化医学

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100 项与 Vac-CRT/E7 (Johns Hopkins University) 相关的专利（医药）

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1

项与 Vac-CRT/E7 (Johns Hopkins University) 相关的文献（医药）

2004-09-01·Vaccine3区 · 医学

Enhancement of vaccinia vaccine potency by linkage of tumor antigen gene to gene encoding calreticulin

3区 · 医学

Article

作者: T. C. Wu ; Michelle Moniz ; David A.K. Boyd ; Liangmei He ; Jeremy Juang ; Pei Jer Chen ; Chia Jung Hsieh ; Chien Fu Hung ; Tae Woo Kim ; Chien Hung Chen

Vaccinia vaccines have become important vectors for antigen-specific immunotherapy. Calreticulin has been shown to enhance MHC class I presentation of linked peptide/protein and may be useful for antigen-specific cancer treatment. An innovative vaccine administering antigen linked to calreticulin via a vaccinia vector may generate a potent antigen-specific antitumor response. We tested the efficacy of linking calreticulin (CRT) to model antigen human papilloma virus type 16 (HPV-16) E7 in the context of a vaccinia vaccine (Vac-CRT/E7). Intraperitoneal vaccination of C57BL/6 mice with Vac-CRT/E7 led to a dramatic increase in E7-specific IFN-gamma-secreting CD8+ T cells and a potent antitumor effect against E7-expressing tumors compared to immunization with Vac-E7 or Vac-CRT. When compared to other chimeric vaccinia vaccines employing various intracellular targeting strategies previously developed in our lab, Vac-CRT/E7 elicited the highest number of E7-specific CD8+ T cells. Thus, vaccination with vaccinia expressing CRT linked to a tumor antigen may represent an advantageous strategy for cancer immunotherapy.

100 项与 Vac-CRT/E7 (Johns Hopkins University) 相关的药物交易

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