A sialosyl sulfonate as a potent inhibitor of influenza virus replication
3区 · 化学
Article
作者: Borbás, Anikó ; Thomson, Robin J. ; Pascolutti, Mauro ; von Itzstein, Mark ; Dyason, Jeffrey C. ; Hadházi, Ádám ; Bailly, Benjamin
A 2-deoxy-sialosyl sulfonate, synthesised in just four steps from sialic acid, is >500-fold more potent against influenza virus sialidase activity and cell infection than its carboxylate isostere.