主要目的: 通过糖化血红蛋白（HbA1c）自基线到第12周的变化，评价不同剂量HL08（0.75mg、1.5mg和3mg）每周一次（QW）皮下注射对单纯依靠饮食和运动血糖控制不佳的T2DM患者的疗效。次要目的: 评价不同剂量HL08在T2DM患者中的安全性。评价不同剂量HL08在T2DM患者中的血糖调控作用。评价HL08在T2DM患者中的群体药代动力学（PopPK）特征。评价HL08在T2DM患者中的免疫原性。

开始日期2024-07-08

申办/合作机构

华兰生物工程股份有限公司

100 项与重组Exendin-4-Fc融合蛋白（华兰生物疫苗）相关的临床结果

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100 项与重组Exendin-4-Fc融合蛋白（华兰生物疫苗）相关的转化医学

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100 项与重组Exendin-4-Fc融合蛋白（华兰生物疫苗）相关的专利（医药）

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项与重组Exendin-4-Fc融合蛋白（华兰生物疫苗）相关的文献（医药）

2022-02-10·Journal of medicinal chemistry1区 · 医学

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile

1区 · 医学

Article

作者: Enyedy, Eva A. ; Madejski, Christian ; Arion, Vladimir B. ; Dömötör, Orsolya ; Wittmann, Christopher ; Bacher, Felix ; Spengler, Gabriella ; Reynisson, Jóhannes

A series of latonduine and indoloquinoline derivatives HL¹-HL⁸ and their copper(II) complexes (1-8) were synthesized and comprehensively characterized. The structures of five compounds (HL⁶, [CuCl(L¹)(DMF)]·DMF, [CuCl(L²)(CH₃OH)], [CuCl(L³)]·0.5H₂O, and [CuCl₂(H₂L⁵)]Cl·2DMF) were elucidated by single crystal X-ray diffraction. The copper(II) complexes revealed low micro- to sub-micromolar IC₅₀ values with promising selectivity toward human colon adenocarcinoma multidrug-resistant Colo320 cancer cells as compared to the doxorubicin-sensitive Colo205 cell line. The lead compounds HL⁴ and 4 as well as HL⁸ and 8 induced apoptosis efficiently in Colo320 cells. In addition, the copper(II) complexes had higher affinity to DNA than their metal-free ligands. HL⁸ showed selective inhibition for the PIM-1 enzyme, while 8 revealed strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1, from a panel of 50 kinases. Furthermore, molecular modeling of the ligands and complexes showed a good fit to the binding pockets of these targets.

1969-07-01·EXPERIMENTAL BIOLOGY AND MEDICINE

Biological Characteristics and Viral Spectrum of Serially Cultivated Fetal Rhesus Monkey Kidney Cells

Article

作者: Stanley L. Inhorn ; James D. Cherry ; Edmund Sheaff ; Marjorie L. Forman

SummaryA serially cultivated tissue, designated HL-8, has been developed from fetal rhesus monkey kidney. A limited supply, frozen in liquid nitrogen, is available (ECD).3 The tissue culture exhibits persistent aneuploidy with a mean diploid chromosome number. It displays contact inhibition, an epithelial-like appearance in sparse culture, and consistent morphology and viral susceptibility during an approximately 13-month lifespan in vitro. The viral spectrum is comparable to primary rhesus monkey kidney tissue culture. HL-8 was able to support the growth of enteroviruses as well as primary MK. Laboratory adenovirus and re-ovirus strains grew and could be passed on HL-8, as could vaccinia and rubella. Surprisingly, HL-8 was successful in the recovery of several myxoviruses including virulent and vaccine measles. As with other serially cultivated cells, HL-8 was significantly inferior for propagation of influenza A2 and parainfluenza 1.

100 项与重组Exendin-4-Fc融合蛋白（华兰生物疫苗）相关的药物交易

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