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更新于：2025-03-20

Undecenoic Acid

十一烯酸

更新于：2025-03-20

概要

基本信息

药物类型

小分子化药

别名

10-undecenoic acid、Undeculenic Acid Tincture、Undecylenate

+ [6]

靶点-

作用方式-

作用机制-

治疗领域

感染皮肤和肌肉骨骼疾病

在研适应症

真菌病足癣

非在研适应症-

原研机构

湖北康源药业有限公司

在研机构

湖北康源药业有限公司

非在研机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C11H20O2

InChIKeyFRPZMMHWLSIFAZ-UHFFFAOYSA-N

CAS号112-38-9

关联

100 项与十一烯酸相关的临床结果

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100 项与十一烯酸相关的转化医学

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100 项与十一烯酸相关的专利（医药）

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2,696

项与十一烯酸相关的文献（医药）

2025-04-01·Food Chemistry

Non-targeted and targeted detection of hydrophilic compounds in fu brick tea: A study on samples from major Chinese production regions and different processing stages

Article

作者: Huang, Jianan ; Xu, Junren ; Yuan, Yong ; Yin, Feiyan ; Zhao, Mengmeng ; Li, Na ; Liu, Zhonghua ; Zhu, Mingzhi ; Zhao, Yiqiao ; Wang, Kunbo ; Chao, Jin

Systematic research is still lacking on the content of hydrophilic compounds in Fu Brick Tea (FBT) from major Chinese production regions and their variation patterns during the processing of FBT. This study utilized optimized non-targeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) metabolomics to analyze 73 FBT samples from six regions of China and 30 samples from different stages of FBT processing. 573 and 74 hydrophilic compounds were respectively relatively and absolutely quantified for the first time. Among the 73 FBT samples, alkaloids were the most abundant (26221.76-36701.75 mg/kg), followed by soluble sugars (211372.59-26112.85 mg/kg), organic acids (17014.07-23589.20 mg/kg), amino acids (6664.59-9791.46 mg/kg), nucleotides (1020.33-2175.16 mg/kg), and nucleoside (650.86-1446.26 mg/kg). During the processing of FBT, sugars, acids, nucleotides, and nucleosides increased, while amino acids decreased, and alkaloids slightly increased. This study enhances the understanding of hydrophilic compounds in FBT.

2025-04-01·Journal of Applied Toxicology

Skin Sensitization Potency Prediction Based on Read‐Across (RAx) Incorporating RhE‐Based Testing Strategy (RTSv1)–Defined Approach: RTSv1‐Based RAx

Article

作者: Miyazawa, Masaaki ; Mizumachi, Hideyuki ; Suzuki, Sho

ABSTRACTIn recent years, nonanimal approaches for skin sensitization have been developed in response to political, regulatory, and ethical demands. The reconstructed human epidermis (RhE)–based testing strategy (RTS)v1–defined approach (DA) is used to categorize skin sensitization potency. However, the RTSv1 DA alone cannot be used to predict potency based on EC3 values [the estimated concentration that produces a stimulation index of 3 in the local lymph node assay (LLNA)], and underpredictions have been reported. Read‐across (RAx) can complement DA data and improve prediction confidence. Although case studies combining new approach methodology/DA data with RAx have been reported, they focus on a single target chemical and lack a comprehensive and robust strategy with well‐examined reliability. This study developed a strategy incorporating the RTSv1 DA into RAx (RTSv1‐based RAx) to predict skin sensitization potency, applying it to 43 chemicals. The predictive performance of RTSv1‐based RAx was evaluated by comparing its predicted potency category and EC3 outcomes with those of RTSv1 DA and the LLNA. RTSv1‐based RAx accurately predicted the Globally Harmonized System of Classification (GHS) subcategorization for 38 chemicals and determined the predicted EC3 values for 17 sensitizers within a fourfold range of LLNA‐derived EC3 values. This study demonstrates that RTSv1‐based RAx offers robust predictivity for both GHS subcategorization and predicted EC3 values, making it useful for quantitative risk assessment.

2025-03-01·Chinese Journal of Chemistry

Hemilabile α‐Diimine Nickel Catalyzed Olefin Polymerization

作者: Pang, Wenmin ; Liu, Yue ; Chen, Ao ; Khan, Muhammad Asadullah ; Chen, Min

Comprehensive SummaryFor coordination‐insertion olefin polymerization, the development of novel transition‐metal catalysts has drawn extensive attention in this field. In this contribution, we designed a series of hemilabile α‐diimine nickel catalysts bearing oxygen atom as neighboring group. The steric hindrance and oxygen atom number of these nickel complexes (Ni1—Ni4) could be adjusted, which influenced ethylene (co)polymerization processes. The introduction of oxygen atoms could enhance the thermal stability during ethylene polymerization for Ni2 compared to the counterpart without oxygen atoms. And for the copolymerization process of ethylene with polar monomers, higher catalytic activity (1.4 × 106 g·mol−1·h−1) and polar monomer incorporation ratio (1.2 mol%) were achieved. However, Ni4 with four oxygen atoms in this work was not active in ethylene polymerization due to the interaction between the oxygen atom and nickel catalytic center. The hemilabile effect in this work presented an example to enhance the stability of the α‐diimine nickel catalysts in olefin polymerization.

100 项与十一烯酸相关的药物交易

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