作者: Maruyama, Rikiya ; Oh, Myungmi ; Fujieda, Shigeharu ; Kimura, Yuichi ; Fujibayashi, Yasuhisa ; Kudo, Takashi ; Mori, Tetsuya ; Kiyono, Yasushi ; Kositwattanarerk, Arpakorn ; Okazawa, Hidehiko

PURPOSE[⁶²Cu]-diacetyl-bis(N4-methlythiosemicarbazone) (Cu-ATSM) was used to delineate hypoxic tissue in head-and-neck cancer, and its distribution was compared with that of ¹⁸F-FDG.MATERIALS AND METHODSThirty patients with head-and-neck cancer underwent Cu-ATSM and FDG PET within a 1 week interval. Accumulation of tracer for each PET image was converted to SUV. After coregisteration of PET images with individual anatomic images, multiple small ROIs were drawn on the tumor mass and applied to both PET images. SUV values were obtained for all ROIs (SUV(roi)), and the SUV(roi) regression lines between Cu-ATSM and FDG of each tumor were determined.RESULTSThe SUV mean of Cu-ATSM was lower than that of FDG for both squamous cell carcinoma (SCC) and adenocarcinoma (P < 0.05). In 27 patients with SCC, Cu-ATSM accumulated higher in the peripheral region than in the center of the tumor, and FDG showed the other tendency. Thus, the relationship of the SUV(roi) for Cu-ATSM and FDG showed a negative correlation in SCC. However, 3 adenocarcinoma cases showed similar and homogenous accumulation in the tumor mass with a positive SUV(roi) correlation for the 2 tracers. The regression slope means were -0.12 ± 0.08 for SCC (n = 27) and 0.28 ± 0.12 (n = 3) for adenocarcinoma.CONCLUSIONIn patients with head-and-neck cancer, intratumoral distribution of Cu-ATSM and FDG showed a negative correlation in SCC and a positive correlation in adenocarcinoma. The 2 tracers represented different pathophysiological microenvironments in different tumors, suggesting that noninvasive hypoxic tissue imaging with Cu-ATSM would be beneficial in the pretreatment evaluation of head-and-neck cancer.

2008-02-01·American Journal of Roentgenology2区 · 医学

PET of Hypoxia and Perfusion with ⁶²Cu-ATSM and ⁶²Cu-PTSM Using a ⁶²Zn/⁶²Cu Generator

2区 · 医学

Article

作者: Petry, Neil A. ; Sporn, Thomas A. ; Wong, Terence Z. ; Vlahovic, Gordana ; Lacy, Jeffrey L. ; Dewhirst, Mark W. ; Hawk, Thomas C.

OBJECTIVECopper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g., 62Cu) has advantages for clinical PET, including a lower radiation dose than long-lived radionuclides and serial imaging capability. A 62Zn/62Cu microgenerator and rapid synthesis kits now provide a practical means of producing 62Cu-PTSM and 62Cu-ATSM on-site. Tumors can be characterized with 62Cu-PTSM, 62Cu-ATSM, and 18F-FDG PET scans during one session. We present the initial clinical data in two patients with lung neoplasms.CONCLUSIONHypoxia and perfusion are important parameters in tumor physiology and can have major implications in diagnosis, prognosis, treatment planning, and response to therapy. We have shown the feasibility of performing 62Cu-ATSM and 62Cu-PTSM PET together with FDG PET/CT during a single imaging session to provide information on both perfusion and hypoxia and tumor anatomy and metabolism.

2008-01-07·Physics in Medicine and Biology2区 · 工程技术

Evaluation of rapid dual-tracer⁶²Cu-PTSM +⁶²Cu-ATSM PET in dogs with spontaneously occurring tumors

2区 · 工程技术

Article

作者: Dan J Kadrmas ; Scott McJames ; Thomas C Rust ; Noel F Black

We are developing methods for imaging multiple PET tracers in a single scan with staggered injections, where imaging measures for each tracer are separated and recovered using differences in tracer kinetics and radioactive decay. In this work, signal separation performance for rapid dual-tracer (62)Cu-PTSM (blood flow) + (62)Cu-ATSM (hypoxia) tumor imaging was evaluated in a large animal model. Four dogs with pre-existing tumors received a series of dynamic PET scans with (62)Cu-PTSM and (62)Cu-ATSM, permitting evaluation of a rapid dual-tracer protocol designed by previous simulation work. Several imaging measures were computed from the dual-tracer data and compared with those from separate, single-tracer imaging. Static imaging measures (e.g. SUV) for each tracer were accurately recovered from dual-tracer data. The wash-in (k(1)) and wash-out (k(2)) rate parameters for both tracers were likewise well recovered (r = 0.87-0.99), but k(3) was not accurately recovered for PTSM (r = 0.19) and moderately well recovered for ATSM (r = 0.70). Some degree of bias was noted, however, which may potentially be overcome through further refinement of the signal separation algorithms. This work demonstrates that complementary information regarding tumor blood flow and hypoxia can be acquired by a single dual-tracer PET scan, and also that the signal separation procedure works effectively for real physiologic data with realistic levels of kinetic model mismatch. Rapid multi-tracer PET has the potential to improve tumor assessment for image-guide therapy and monitoring, and further investigation with these and other tracers is warranted.

100 项与 62Cu-ATSM 相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
脑癌	临床1期	-	Japanese National Cancer Center	-
脑癌	临床1期	-	National Institute of Radiological Sciences	-
诊断试剂	临床1期	-	National Institute of Radiological Sciences	-
诊断试剂	临床1期	-	Japanese National Cancer Center	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2014	N/A	肌萎缩侧索硬化	-	62 Cu-ATSM (ALS patients)	壓製觸鑰齋衊淵構顧餘(鑰積觸範窪繭廠範積窪) = 簾鹹鑰遞廠繭觸網襯製鹹壓積膚糧糧觸艱膚鏇 (選範鏇蓋艱淵淵簾窪繭, 0.5)	-	2014-11-05
				62 Cu-ATSM (Healthy controls)	壓製觸鑰齋衊淵構顧餘(鑰積觸範窪繭廠範積窪) = 簾願淵憲顧餘膚遞鏇鹽鹹壓積膚糧糧觸艱膚鏇 (選範鏇蓋艱淵淵簾窪繭, 0.5)