左旋薄荷醇(Levomenthol) - 药物靶点：TRPA1 x TRPM8 x κ opioid receptor_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(-)-(1R,3R,4S)-menthol、(-)-Menthol、(1R,3R,4S)-(-)-menthol

+ [12]

靶点

TRPA1 x TRPM8 x κ opioid receptor

作用方式

抑制剂、激动剂、拮抗剂

作用机制

TRPA1抑制剂(瞬时受体电位离子通道亚基1抑制剂)、TRPM8激动剂(瞬时受体电位离子通道亚科M成员8激动剂)、κ opioid receptor拮抗剂(κ-阿片受体拮抗剂)

治疗领域

消化系统疾病

在研适应症-

非在研适应症

肠道疾病

原研机构

University Hospitals Cleveland Medical Center

在研机构

Fuji Pharma Co., Ltd.

非在研机构

Nihon Pharmaceutical Co., Ltd.

权益机构-

最高研发阶段批准上市

首次获批日期

日本 (1986-01-20)

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C10H20O

InChIKeyNOOLISFMXDJSKH-KXUCPTDWSA-N

CAS号2216-51-5

关联

25

项与左旋薄荷醇相关的临床试验

NCT05888597

/ Recruiting临床2期

Effect of L-menthol on Breathlessness and Exercise Capacity in Chronic Obstructive Pulmonary Disease: a Randomized

The purpose of this study is to assess the effect of L-menthol on breathlessness in patients with chronic obstructive pulmonary disease (COPD).

开始日期2023-05-24

申办/合作机构

Region Skåne Holding AB

[+1]

RBR-7tgfwmk

/ Not yet recruitingN/AIIT

Use of L-menthol solution as an esophageal antispasmodic in Upper Digestive Endoscopy: pilot project

开始日期2021-08-01

申办/合作机构-

JPRN-jRCTs031200400

/ Completed临床2期IIT

Effects of olfactory stimulation by L-menthol on dyspnea on exertion in chronic lung disease: A pilot study

开始日期2021-04-14

申办/合作机构-

100 项与左旋薄荷醇相关的临床结果

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100 项与左旋薄荷醇相关的转化医学

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100 项与左旋薄荷醇相关的专利（医药）

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12,464

项与左旋薄荷醇相关的文献（医药）

2025-06-01·Biochemical Systematics and Ecology

HS-SPME-GC/MS analysis of the volatile components of the resins of different Commiphora Jacq. Species collected in Socotra Island

作者: Attorre, Fabio ; Garzoli, Stefania ; Frezza, Claudio ; De Vita, Daniela ; La Montagna, Dario

In this paper, the volatile phytochem. pattern of the resins of five Commiphora Jacq. species collected in Socotra Island was reported.Different populations were studied, some of which for the first time, by using head space-solid phase microextraction (HS-SPME) sampling technique to collect the volatiles emitted from these species.All the captured volatile compounds in the accessions were identified and quantified by means of Gas-Chromatog./Mass Spectrometry (GC/MS).The obtained results highlighted the presence of terpene compounds, mainly monoterpenes and sesquiterpenes, which followed a different trend among the studied species in accordance with the ecol. of the collection areas of the species.Sesquiterpenes were predominant in C. kua and, in part, in C. ornifolia; monoterpenes were predominant in C. planifrons and C. parvifolia, whereas oxygenated monoterpenes were predominant in C. socotrana.A high number of the so-called other volatile components were found in C. planifrons.The dominant compounds were γ-cadinene in both accessions of C. kua, β-eudesmol in the first accession of C. ornifolia and δ-cadinene in its second accession, limonene in both accessions of both C. planifrons and C. parvifolia, terpinen-4-ol in both accessions of C. socotrana.The meaning of the data was considered under the chemophenetic, ecol. and ethnobotanical aspects.

2025-06-01·Food Chemistry

Enhancing beef flavor profiles via Maillard reaction of γ-Glutamylated beef protein hydrolysates and xylose

Article

作者: Sun, Baoguo ; Zhang, Yuyu ; Zhang, Yuqiang ; Yang, Juan ; Chen, Peiwen ; Bai, Weidong ; Zeng, Xiaofang

Beef protein hydrolysates (BH) and their γ-glutamylated products (γ-BH and γ-GBH, 0 and 7 % L-Gln extra-addition) were prepared, followed by xylose-induced Maillard reaction. Maillard reaction products (MRPs) of γ-glutamylated products (γ-BH-MRP and γ-GBH-MRP) showed a higher degree of Maillard reaction and improved sensory characteristics (p < 0.05). Specifically, UV absorbances and fluorescence intensity of MRPs significantly increased (p < 0.05), and there were significant increases in kokumi, umami, saltiness, roast, and meaty flavors, and a reduction in bitterness (p < 0.05) after γ-glutamylation. In γ-BH-MRP and γ-GBH-MRP, the relative content of most flavor compounds increased significantly (p < 0.05), especially pyrazines and furans, and 8 and 10 new flavor compounds were also detected. 7 and 25 new γ-glutamyl peptides were identified, with their contents ranging 2.26-8.38 μM and 1.93-71.90 μM, respectively. These data illustrate that γ-glutamylation can promote the formation of MRPs, thereby improving the flavor characteristics of beef flavorings.

2025-05-01·Journal of Colloid and Interface Science

Integrated Janus gel with bilayered heterostructure for high-performance supercapacitors

Article

作者: Wang, Lin ; Hao, Jingcheng ; Sun, Xinyu ; Wang, Zeyi ; Qiu, Xiaoyong ; Qian, Yuzhen

A persistent challenge for electrolytes is achieving simultaneous compatibility with both electrodes under high-voltage conditions, which has restricted the power output of energy storage devices. Herein, we developed an integrated Janus gel electrolyte with a bilayer heterostructure to extend the potential limits on both the cathode and anode. This electrolyte consisted of a deep eutectic solvent (DES) gel phase and an ionic liquid (IL) gel phase. The DES gel layer functioned as the anolyte, benefiting from its reduction tolerance through internal H-bond interactions, while the IL gel phase served as the catholyte, taking advantage of the high oxidation resistance of TFSI^-. Moreover, the miscibility between DES and IL enabled full integration of the intermediate layer, effectively reducing interfacial transmission impedance and promoting ions migration. The fabricated Janus gel demonstrated a wide electrochemical window (4.70 V), satisfactory ionic conductivity (3.57 mS/cm), and excellent temperature tolerance. A supercapacitor incorporating this Janus gel electrolyte delivered an energy density of 89.4 Wh/kg at the power density of 646.2 W/kg under the voltage window of 3.6 V (-1.8∼1.8 V), along with robust cycling stability over 10,000 charge-discharge cycles. An energy density of 31.4 Wh/kg at a power density of 386.5 W/kg could be maintained in the voltage range of 0∼1.8 V. This research provides novel insights into the design of engineered electrolytes that are high compatible with both the cathode and anode in high-voltage applications.

100 项与左旋薄荷醇相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	左旋薄荷醇	-	DB00825

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肠道疾病	药物发现	日本	Nihon Pharmaceutical Co., Ltd.	2014-10-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


UEGW2017	N/A	-	-	Menthol infusion	醖憲獵醖鏇夢範憲繭齋(範願構窪壓選夢構襯夢) = 製齋網網顧壓鏇膚觸蓋鏇餘蓋顧獵糧淵獵襯衊 (簾膚襯餘餘選襯獵鑰鑰, 116.2) 更多	-	2017-10-01
UEGW2017	N/A	-	-	L-Menthol (Baseline recording)	醖憲獵醖鏇夢範憲繭齋(範願構窪壓選夢構襯夢) = 範廠獵廠簾積繭鬱艱鏇鏇餘蓋顧獵糧淵獵襯衊 (簾膚襯餘餘選襯獵鑰鑰, 126.2) 更多	-	2017-10-01
NCT01687101 (CTgov)	N/A	偏头痛 \| 头痛	32	STOPAIN topical gel	網積鹹醖範鬱淵齋夢簾(夢襯顧網鏇願鏇淵鬱遞) = 餘齋築壓廠襯積觸鑰艱網膚鑰網鏇憲顧繭醖醖 (鬱艱繭齋艱願膚襯壓鑰, 鑰餘艱衊鑰簾齋膚簾鏇 ~ 艱顧簾鑰範餘糧壓襯鬱) 更多	-	2015-04-27