Polymyxin B Sulfate/Trimethoprim Sulfate(Polymyxin B Sulfate/Trimethoprim Sulfate)

概要

基本信息

药物类型

小分子化药

别名

Polytrim

靶点-

作用机制

细胞膜功能抑制剂

治疗领域

感染眼部疾病

在研适应症-

非在研适应症

眼部感染

原研机构

Allergan Ltd. (Ireland)

在研机构-

非在研机构

Allergan, Inc.

最高研发阶段撤市

首次获批日期

美国 (1988-10-20),

眼部感染

最高研发阶段(中国)-

特殊审评-

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结构

分子式C14H20N4O7S

InChIKeyGSKPSSNZVPYRCH-UHFFFAOYSA-N

CAS号56585-33-2

关联

3

项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的临床试验

NCT05331664 / Recruiting临床4期IIT

Dropless Pars Plana Vitrectomy Study

To demonstrate that intraoperative use of subtenon triamcinolone acetonide at the time of surgery without postoperative eye drops is non-inferior to the regimen of postoperative eye drops following primary pars plana vitrectomy for retinal detachment.

开始日期2022-07-25

申办/合作机构

Massachusetts Eye & Ear Infirmary, Inc.

NCT03920007 / Active, not recruiting临床1/2期

A Phase 1/2 Dose Escalation Study of Subretinally Injected ATSN-101 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D

Primary Objective:
To evaluate the safety and tolerability of ascending doses of ATSN-101 administered as a unilateral subretinal injection in patients with Leber Congenital Amaurosis (LCA) caused by autosomal recessive guanylate cyclase 2D (GUCY2D) mutations (GUCY2D-LCA).
Secondary Objective:
To evaluate the efficacy of ascending doses of ATSN-101 administered as a unilateral subretinal injection in patients with GUCY2D-LCA.

开始日期2019-09-12

申办/合作机构

Atsena Therapeutics, Inc.初创企业

NCT00581542 / Completed临床4期IIT

A Single Blinded Clinical Trial Comparing Polytrim Ophthalmic Solution and Moxifloxacin Ophthalmic Solution for Treatment of Conjunctivitis.

The purpose of the study is to compare the effect of Polytrim Ophthalmic Solution and Moxifloxacin Ophthalmic Solution in treating your child's pink eye. Both these medications are approved by the Food and Drug Administration, for treatment of conjunctivitis. This study will investigate if both of the medications are equally good.

开始日期2007-03-01

申办/合作机构

University of Rochester

100 项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的临床结果

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100 项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的转化医学

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100 项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的专利（医药）

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9

项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的文献（医药）

2020-12-01·Cornea3区 · 医学

The Search for Antifungal Prophylaxis After Artificial Corneal Surgery—An In Vitro Study

3区 · 医学

Article

作者: Mitragotri, Samir ; Bispo, Paulo J M ; Behlau, Irmgard ; Kim, Sarah ; Dohlman, Claes H ; Chodosh, James ; Gipson, Ilene ; E Silva, Rafaella N ; Gilmore, Michael S ; Paschalis, Eleftherios I ; Tanner, Eden E L

Purpose:To evaluate the antifungal properties of topical antibiotics (already being used successfully to prevent bacterial endophthalmitis) and some promising antiseptics for antifungal prophylaxis in the setting of artificial corneal implantation.Methods:Several commonly used antibiotics for antimicrobial prophylaxis after artificial corneal implantation, in addition to antiseptics [benzalkonium chloride (BAK), povidone-iodine (PI), and some ionic liquids (ILs)], were tested in vitro against Candida albicans, Fusarium solani, and Aspergillus fumigatus. The time–kill activity was determined. Toxicity was assayed in vitro on human corneal epithelial cultures using trypan blue. Adhesion and tissue invasion experiments were also carried out on porcine corneas and commonly used contact lenses, with or without gamma irradiation, and by analysis with fluorescence microscopy.Results:Polymyxin B (PMB)/trimethoprim/BAK (Polytrim), PMB alone, gatifloxacin with BAK (Zymaxid), and same-concentration BAK alone exhibited antifungal activity in vitro. Moxifloxacin (MOX) or gatifloxacin without BAK—as well as trimethoprim, vancomycin, and chloramphenicol—had no effect. 1% PI and ILs had the highest efficacy/toxicity ratios (>1), and Polytrim was species dependent. Subfungicidal concentrations of Polytrim reduced adhesion of C. albicans to Kontur contact lenses. Gamma-irradiated corneas showed enhanced resistance to fungal invasion.Conclusions:Of antibiotic preparations already in use for bacterial prophylaxis after KPro surgery, Polytrim is a commonly used antibiotic with antifungal effects mediated by both PMB and BAK and may be sufficient for prophylaxis. PI as a 1% solution seems to be promising as a long-term antifungal agent. Choline-undecanoate IL is effective and virtually nontoxic and warrants further development.

2017-09-01·American Journal of Ophthalmology Case Reports

Crystalline lens dislocation secondary to bacterial endogenous endophthalmitis

作者: Komati, Rahul ; Weinmann, Allison ; Sangave, Amit ; Samuel, Linoj ; Desai, Uday

PURPOSETo present an unusual case of endogenous endophthalmitis secondary to Group A streptococcus (GAS) that resulted in dislocation of the crystalline lens.OBSERVATIONSAn immunocompetent 51-year-old man presented to the emergency room (ER) with upper respiratory infection (URI) symptoms and painful right eye. He was diagnosed with URI and viral conjunctivitis and discharged on oral azithromycin and polytrim eyedrops. He returned to the ER 30 h later with sepsis and findings consistent with endophthalmitis, including light perception only vision. Ophthalmology was consulted at this time and an emergent vitreous tap and injection was performed. Both blood and vitreous cultures grew an atypical non-hemolytic variant of GAS (Streptococcus pyogenes). The primary source of infection was presumed to be secondary to pharyngitis or cutaneous dissemination. Final vision in the affected eye was no light perception, likely from a combination of anterior segment scarring, posterior segment damage, and hypotony. Interestingly, head computed tomography (CT) at the initial ER presentation showed normal lens position, but repeat CT at re-presentation revealed posterior dislocation of the lens.CONCLUSIONS AND IMPORTANCEEndophthalmitis secondary to GAS has been sparsely reported in the literature, and this case highlights a unique clinical presentation. We suspect that this atypical non-hemolytic strain may have evaded detection on initial pharyngeal cultures. Additionally, we hypothesize that GAS-mediated protease release resulted in breakdown of the zonular fibers and subsequent lens dislocation. Ophthalmologists should be aware of GAS and its devastating intraocular manifestations.

2014-01-01·Case Reports in Rheumatology

Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis

Article

作者: Nguyen, Jacqueline ; Kesavarapu, Keerthana ; Meadow, Philip B.

Purpose.To report a case of a patient with rheumatoid arthritis (RA) treated with tofacitinib citrate.Methods.Observational case report.Results.A 59-year-old patient, with a history of rheumatoid arthritis, on methotrexate 10 mg PO qwk and IV abatacept 750 mg/month, presented with photosensitivity, foreign body sensation, pain, redness, and blurry vision of her right eye (RE). Visual acuity of the RE was 20/200 and 20/20 of the left eye (LE). The slit lamp examination of the RE revealed dryness, 2+ injection of the conjunctiva, and pericentral ulceration of the cornea with 20–30% stromal thinning, pannus, and diffuse punctate epithelial erosions. The anterior chamber appeared normal. Laboratory values revealed elevated levels of rheumatoid factor, anticyclic citrullinated peptide antibodies, and C-reactive protein. The patient was switched to tofacitinib citrate 5 mg PO b.i.d, underwent corneal gluing, and was given prednisone acetate 1% gt TID, polytrim gt TID, neomycin-polymyxin-dexameth gt QD, FreshKote lubricant 1.8% gt QID, moxifloxacin 0.5% gt QID, and preservative free artificial tears Q1H. Within one week, laboratory values normalized, symptoms diminished, and the cornea reepithelialized.Conclusion.RA can present with ulcerative keratitis. Tofacitinib citrate, steroids, and corneal gluing were found to halt the progression of keratolysis and promote reepithelialization.

100 项与 Polymyxin B Sulfate/Trimethoprim Sulfate 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	S02AA30	-

研发状态

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2015	N/A	泪器阻塞	-	Besivance	(齋醖構顧網選願顧艱簾) = 鬱觸鏇願襯簾膚網鹽鑰憲構憲壓製構繭鬱顧膚 (糧鏇鹽淵繭衊鏇簾鹽製 ) 更多	-	2015-06-01
				Polytrim	(齋醖構顧網選願顧艱簾) = 艱選窪鹹齋廠選憲壓鹹憲構憲壓製構繭鬱顧膚 (糧鏇鹽淵繭衊鏇簾鹽製 ) 更多