Application of PD-1 Monoclonal Antibody in Combination With IL-2 and CapeOX in Organ Preservation Therapy for Ultra-Low Localized Advanced Rectal Cancer: A Single-center, Single-arm, Open-label Clinical Study (PICTURE)

The objective is to evaluate whether the neoadjuvant combination of PD-1 inhibitor tislelizumab and interleukin-2 (IL-2) can significantly enhance the complete response rate (cCR + local excision pCR) and organ preservation rate in patients with MSS/pMMR locally advanced rectal cancer.

开始日期2024-07-10

申办/合作机构

南京医科大学第三附属医院

100 项与重组人白细胞介素-2 (125ALa) (北京双鹭药业) 相关的临床结果

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100 项与重组人白细胞介素-2 (125ALa) (北京双鹭药业) 相关的转化医学

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100 项与重组人白细胞介素-2 (125ALa) (北京双鹭药业) 相关的专利（医药）

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项与重组人白细胞介素-2 (125ALa) (北京双鹭药业) 相关的文献（医药）

2017-01-01·Neural Regeneration Research2区 · 医学

Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation

2区 · 医学

ArticleOA

作者: Li, Yan ; Reeju, Maharjan ; Wang, Na ; Xue, Di ; Huang, Shu-Ming ; Liu, Xue-Wei ; Zhang, Bo ; Jia, Yong-Ming

Kai Xin San is a Chinese herbal formula composed of Radix Ginseng, Poria, Radix Polygalae and Acorus Tatarinowii Rhizome. It has been used in China for many years for treating amnesia. Kai Xin San ameliorates amyloid-β (Aβ)-induced cognitive dysfunction and is neuroprotective in vivo, but its precise mechanism remains unclear. Expression of insulin-degrading enzyme (IDE), which degrades Aβ, is strongly correlated with cognitive function. Here, we injected rats with exogenous Aβ₄₂ (200 μM, 5 μL) into the hippocampus and subsequently administered Kai Xin San (0.54 or 1.08 g/kg/d) intragastrically for 21 consecutive days. Hematoxylin-eosin and Nissl staining revealed that Kai Xin San protected neurons against Aβ-induced damage. Furthermore, enzyme-linked immunosorbent assay, western blot and polymerase chain reaction results showed that Kai Xin San decreased Aβ₄₂ protein levels and increased expression of IDE protein, but not mRNA, in the hippocampus. Our findings reveal that Kai Xin San facilitates hippocampal Aβ degradation and increases IDE expression, which leads, at least in part, to the alleviation of hippocampal neuron injury in rats.

2014-01-01·The Prostate3区 · 医学

Is digoxin use for cardiovascular disease associated with risk of prostate cancer?

3区 · 医学

Article

作者: Stanford, Janet L. ; Hansten, Philip D. ; Wright, Jonathan L.

AbstractPURPOSEDigoxin is a commonly used medication for heart failure and cardiac arrhythmias that has recently been suggested as a novel chemotherapeutic agent. Preclinical studies of prostate cancer (PCa) have shown anti‐tumor activity with digoxin. We explore the relationship between use of digoxin and PCa risk.METHODSData from a population‐based case–control study of incident cases aged 35–74 years at PCa diagnosis in 2002–2005 in King County, Washington were available. Controls were identified by random digit dialing and frequency matched by age. Use of digoxin was determined from in‐person questionnaires regarding medical and prescription history. The relationship of digoxin use with PCa risk was evaluated with logistic regression.RESULTSOne thousand one cases of PCa and 942 controls were analyzed. The prevalence of digoxin use in controls was 2.7%, and use was positively correlated with age. In multivariate analysis adjusting for age, race, PSA screening, and family history of PCa, digoxin use was associated with a reduction in the odds ratio of PCa (OR 0.58, 95% CI: 0.30–1.10). Among those with ≥3 PSA tests over the preceding 5 years (546 cases, 380 controls), digoxin use was associated with a stronger reduction of PCa risk (OR 0.44, 95% CI: 0.20–0.98).CONCLUSIONThese data indicate digoxin use may be associated with a reduction in risk of PCa. Given the potential mechanisms by which digoxin may exert an anti‐neoplastic effect and other recent studies showing a negative association between digoxin use and PCa, further research is warranted. Prostate 74:97–102, 2014. © 2013 Wiley Periodicals, Inc.

2012-01-01·American Journal of Physiology-Cell Physiology3区 · 生物学

Skeletal muscle regeneration is delayed by reduction in Xin expression: consequence of impaired satellite cell activation?

3区 · 生物学

Article

作者: Labatia, Rita ; van der Ven, Peter F. M. ; Atkinson, Daniel J. ; Hawke, Thomas J. ; Zemanek, Bart ; Fürst, Dieter O. ; Nissar, Aliyah A.

Xin is a striated muscle-specific actin-binding protein whose mRNA expression has been observed in damaged skeletal muscle. Here we demonstrate increased Xin protein expression early postinjury (≤12 h) and localization primarily to the periphery of damaged myofibers. At 1 day postinjury, Xin is colocalized with MyoD, confirming expression in activated satellite cells (SCs). By 5 days postinjury, Xin is evident in newly regenerated myofibers, with a return to preinjury levels by 14 days of regeneration. To determine whether the increased Xin expression is functionally relevant, tibialis anterior muscles of wild-type mice were infected with Xin-short hairpin RNA (shRNA) adenovirus, whereas the contralateral tibialis anterior received control adenovirus (Control). Four days postinfection, muscles were harvested or injured with cardiotoxin and collected at 3, 5, or 14 days thereafter. When compared with Control, Xin-shRNA infection attenuated muscle regeneration as demonstrated by Myh3 expression and fiber areas. Given the colocalization of Xin and MyoD, we isolated single myofibers from infected muscles to investigate the effect of silencing Xin on SC function. Relative to Control, SC activation, but not proliferation, was significantly impaired in Xin-shRNA-infected muscles. To determine whether Xin affects the G0-G1 transition, cell cycle reentry was assessed on infected C2C12 myoblasts using a methylcellulose assay. No difference in reentry was noted between groups, suggesting that Xin contributes to SC activation by means other than affecting G0-G1 transition. Together these data demonstrate a critical role for Xin in SC activation and reduction in Xin expression results in attenuated skeletal muscle repair.

100 项与重组人白细胞介素-2 (125ALa) (北京双鹭药业) 相关的药物交易

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适应症	国家/地区	公司	日期
腹水	中国	北京双鹭药业股份有限公司	1999-01-01
感染	中国	北京双鹭药业股份有限公司	1999-01-01
肺癌	中国	北京双鹭药业股份有限公司	1999-01-01
淋巴瘤	中国	北京双鹭药业股份有限公司	1999-01-01
黑色素瘤	中国	北京双鹭药业股份有限公司	1999-01-01
类风湿关节炎	中国	北京双鹭药业股份有限公司	1999-01-01