更新于：2024-11-21

GV-328

更新于：2024-11-21

概要

研发状态

概要

基本信息

药物类型

化学药

别名-

靶点-

作用机制-

治疗领域

感染口颌疾病其他疾病

在研适应症-

非在研适应症

口蹄疫口疮性口炎

原研机构

Universitat Internacional de Catalunya

在研机构-

非在研机构

Universitat Internacional de Catalunya

最高研发阶段无进展临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

项与 GV-328 相关的临床试验

NCT04677062 / CompletedN/AIIT

Safety, Galenic Acceptability and Efficacy of GV-328 Lozenges in Children With Oral Aphthosis

The aim of the study was to assess the safety, acceptability, and efficacy of product GV-328 for the treatment of childhood oral aphthous lesion.

开始日期2017-11-01

申办/合作机构

Universitat Internacional de Catalunya

100 项与 GV-328 相关的临床结果

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100 项与 GV-328 相关的转化医学

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100 项与 GV-328 相关的专利（医药）

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项与 GV-328 相关的文献（医药）

2022-04-01·Atención Primaria4区 · 医学

Estudio clínico de seguridad, aceptabilidad galénica y eficacia del preparado GV-328 en la aftosis oral infantil

4区 · 医学

ArticleOA

作者: Guinot Jimeno, Francisco ; Veloso Durán, Ana ; Fernández Sencion, Jessica Nicole ; Giner Tarrida, Luis

2018-08-01·Life Sciences3区 · 医学

The role of miR-328 in high glucose-induced endothelial-to-mesenchymal transition in human umbilical vein endothelial cells

3区 · 医学

Article

作者: Ke, Junsong ; Huang, Jun ; Chen, Yunxiao ; Yang, Qin ; Zhan, Yuliang ; Lv, Ping

AIMSEndothelial-to-mesenchymal transition (EndMT) contribute to diabetic cardiac fibrosis, the underlying mechanisms are poorly understood. In the study, we aimed to investigate the role of miR-328 in EndMT mediated by high glucose (HG) and the signaling pathways implicated in human umbilical vein endothelial cells (HUVECs).MATERIALS AND METHODSEndMT of HUVECs was determined by immunofluorescent staining and western blot of the markers CD31 and α-SMA. Real-time polymerase chain reaction was used to detect mRNA expression of miR-328 and transforming growth factor β₁ (TGF-β₁). SB431542 was used to study the relation of miR-328 and TGF-β₁ during EndMT induced by HG. Over-expression and inhibition of miR-328 were achieved by transduction of miR-328 and antagomiR-328. The effects of miR-328 on expression of type I and III collagen, p-MEK1/2, p-ERK1/2 were examined by Western blot.KEY FINDINGSThe level of miR-328 was significantly up-regulated in HG-induced EndMT. MiR-328 showed the independent capability of inducing EndMT, which was not related to TGF-β₁, and this effect was abrogated by antagomiR-328. MiR-328 affected type I collagen in a time- and dose-dependent manner and enhanced protein expression of type I and III collagens. Further investigation displayed that a significantly higher expression of p-MEK1/2 and p-ERK1/2 in HUVECs transduced with miR-328, and a lower expression of p-MEK1/2 and p-ERK1/2 in cells transduced with antagomiR-328.SIGNIFICANCEThese results suggest a novel role for miR-328 in HG-induced EndMT, MEK1/2-ERK1/2 pathway is likely to be involved in the associated effects. Our findings may suggest antagomiR-328 as an alternative agent in prevention of HG-induced EndMT.

2015-04-01·Zhongguo shi yan xue ye xue za zhi

[miR-328 Inhibits K562 Cell Proliferation by Up-regulation of C/EBPα Expression].

Article

作者: Li, Jun-Jun ; Wen, Feng ; Wang, Hao ; Cao, Jin-Xia ; Liao, Pei

OBJECTIVEOur research was aim to investigate the effect of microRNA-328 (miR-328) on proliferation of chronic myeloid leukemia(CML) cell K562 and the mediated effect of C/EBPα.METHODSThe eukaryotic expression vectors of miR-328 targeting gene and suppressor gene (hsa-miR-328 and hsa-miR-328-inhibitor) were constructed, and transfected into K562 cells respectively. The mRNA expression levels of miR-328 and C/EBP α were detected by real-time fluorescence quantitative RT-PCR; C/EBP α protein expression was detected by Western blot; CCK-8 was used to estimate the cell viability.RESULTSThe recombinant genes of hsa-miR-328 and hsa-miR-328-inhibitor were successfully constructed and transfected into K562 cells. Fluorescent cells were observed after 24 h, and the visible fluorescence cells were gradually increased after 48 h or 72 h, the miR-328 showed no effect on the mRNA expression of C/EBPα detected by RT-PCR. Meanwhile, miR-328 showed recovering effect on C/EBPα translation and inhibition of K562 cells proliferation.CONCLUSIONmiR-328 has been successfully constructed and transfected into K562 cells, miR-328 inhibits the proliferation of K562 cells by up-regulation of C/EBPα.

100 项与 GV-328 相关的药物交易

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