Comparing the effect of pre-operative doses of betamethasone acetate 0.1% and placebo on control of eye inflammation and pain after cataract surgery in patients who undergo phacoemulsification surgery.

开始日期2017-03-21

申办/合作机构

Mashhad University of Medical Sciences

IRCT2017103037105N1 / Completed临床2/3期IIT

Study the effect of pre-operative doses of betamethasone acetate 0.1% on dry eye control and visual acuity after cataract surgery in patients referring to Khatam-al-Anbia hospital in 2016-2017

开始日期2016-11-04

申办/合作机构-

NCT02652884 / Unknown status临床4期IIT

Evaluation of Potential Benefits of Using Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy

The incidence of thyroid cancer (TC) has increased exponentially worldwide. The increase in diagnosed cases brings about an increase in the number of surgeries performed on the thyroid gland, especially total thyroidectomy (TT), given that at present is still the gold standard of treatment.
Transient postoperative hypoparathyroidism (HPT) is one of the most frequent complications, with an incidence of between 10 and 46% according to different sources. HPT involves longer hospital stay, serial measurements of blood glucose, treatment with calcium and vitamin D (with potential risk of hypercalcemia) and therefore an increase in terms of the costs of the health system.
While the investigators know the analgesic, anti-inflammatory, immunomodulatory and anti emetic of corticosteroids in thyroid surgery, the literature available to date is discordant in the use of steroid and its interaction with the HPT making clear the need for randomized clinical trials specific to analyze these variables more accurately.
As inflammation and edema constitute a proposed surgical manipulation in the pathogenesis of HPT component, investigators decided t conduct a prospective randomized, triple-blind, in order to assess the potential benefits of the most common postoperative complication reported in TT.
Our primary objective is to evaluate the safety and efficacy of single-dose corticosteroids deposit immediately postintubation in preventing the development of transient hypoparathyroidism (PTH, serum calcium and symptoms) in patients after TT.

开始日期2016-01-01

申办/合作机构

Hospital Italiano de Buenos Aires

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100

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2024-05-04·The Veterinary record

Clinical safety and efficacy of a single‐dose gentamicin, posaconazole and mometasone furoate otic suspension for treatment of canine otitis externa

Article

作者: Wilhelm, Cornelia ; Wolf, Oliver ; Löhlein, Wolfgang ; Roy, Olivier ; Heuer, Lea ; Zschiesche, Eva

Abstract:

Background:

A single‐dose, in‐clinic, veterinary professional‐administered treatment for canine otitis externa was developed to improve compliance and canine welfare.

Methods:

This multicentre, controlled, examiner‐masked, randomised field trial was conducted in 316 dogs over 42 days. Dogs were treated once, on day 0, with the investigational product containing gentamicin, posaconazole and mometasone furoate (Mometamax Ultra [MU]) or twice (days 0 and 7) with a control product containing florfenicol, terbinafine and betamethasone acetate (CP). The primary endpoint was a composite otitis index score of 4 or less (of 12) on day 14 and 3 or less (of 12) on day 28.

Results:

On day 28, treatment success was recorded in 128 of 143 MU‐treated dogs (89.5%), significantly non‐inferior to 116 of 133 (87.2%) CP‐treated dogs (Farrington‐Manning test, Z = 4.1351, p < 0.0001). For mixed cultures of Staphylococcus pseudintermedius and Malassezia pachydermatis, there was 100% treatment success in MU‐treated dogs (n = 33), significantly non‐inferior to 90.2% (37 of 41) in CP‐treated dogs (Farrington–Manning test, Z = 3.1954, p = 0.0007).

Limitations:

Efficacy in chronic otitis externa cases was not investigated. Cytology was not used to aid in diagnosis or for identification of secondary pathogens.

Conclusion:

This unique combination, single‐dose product is safe and effective in dogs with otitis externa. It offers enhanced compliance, canine welfare and quality of life by eliminating the owner burden of treating this painful condition.

2023-10-01·Hand (New York, N.Y.)

Effects of Premixing Betamethasone and Lidocaine on Chondrocyte Inflammation in an In Vitro Model

Article

作者: Intravia, Jessica M. ; Grande, Daniel ; Larsen, Christopher G. ; Pinpin, Camille ; Nellans, Kate W. ; Lane, Lewis B. ; Sayegh, Michael J. ; Neufeld, Eric V.

Background::

It is common practice for hand surgeons to premix corticosteroids with a local anesthetic and store the mixture in pre-loaded syringes for rapid use during clinic. However, any possible loss of efficacy with this practice has never been studied. The purpose of this study, therefore, is to determine whether premixing betamethasone sodium phosphate/betamethasone acetate (BSP) and lidocaine (L) at different time intervals from injection has diminishing anti-inflammatory effects on chondrocytes in vitro.

Methods::

Human articular chondrocytes were partitioned into six groups: two controls and four experimental conditions. The negative control had growth media only. The positive control had growth media and inflammatory cytokines (interleukin-1β and oncostatin M). Experimental conditions were additionally treated with BSP alone or BSP mixed with lidocaine (BSP + L) at the time of treatment (0 hours), or at 4 or 24 hours prior. Relative expressions of inflammatory genes were measured.

Results::

Relative to the positive control, chondrocytes in all experimental conditions decreased expression of TNF-α, MMP-3, and ADAMTS-4. Chondrocytes exposed to BSP only or BSP + L at 4 hours or 24 hours prior to treatment decreased expression of IL-8. Chondrocytes exposed to BSP only or BSP + L at 0 hours or 4 hours prior to treatment decreased expression of MMP-1. There were no significant differences in expression of IL-6 or MMP-13.

Conclusions::

Treatment with BSP + L prepared in pre-loaded syringes at varying time intervals up to 24 hours prior to injection does not significantly impact the ability of the mixture to reduce expression of certain key inflammatory mediators in vitro.

2023-10-01·World neurosurgery

Comparison of the Particulate Steroids, Betamethasone and Methylprednisolone, in Caudal Steroid Injection Under Ultrasound Guidance

Article

作者: Senol, Yigit Can ; Guler, Ali ; Dalgic, Ali ; Akpinar, Afsin Emre ; Gunerhan, Goksal

BACKGROUND:

Pain relief in lumbar disc hernias is a challenging condition. This study retrospectively compared particulate steroids, methylprednisolone acetate (mid-term effective), against betamethasone acetate (long-term effective) on ultrasound-guided caudal epidural injection for lumbar disc herniation.

METHODS:

A total of 40 patients with L4-5 and/or L5-S1 disc herniation were treated with ultrasound-guided caudal epidural injection between September 2021 and June 2022. Nineteen patients who were given methylprednisolone acetate (group A) as a steroid and a total of 21 patients who were used betamethasone acetate (Group B) were retrospectively collected, and their pain levels and functional improvement were compared retrospectively before, immediately after, and 3 weeks after the injection in terms of the visual analog scale (VAS) and Oswestry Disability Index (ODI) as the efficacy value.

RESULTS:

There was no statistically significant difference between the groups regarding age, gender, and body mass index (P > 0.05). In group A, preop VAS was 8.84 ± 0.76, immediate postop period 3.10 ± 1.37, and postop third week was 4.73 ± 2.32. In group B, the preop VAS was 8.76 ± 0.76, the postop early period was 3.14 ± 1.27, and the postop third week was 3.12 ± 1.30. In group A preop ODI was 49.84 ± 9.11 and postop third week was 22.84 ± 6.44. In group B, the preop ODI was 46.71 ± 16.15 and postop third week was 30.80 ± 17.65. Significant changes were observed in the reduction of VAS values after the procedure in both groups during the early postoperative period and the third week (P value < 0.05). However, a significant difference was not found between the changes in VAS values between the groups (P value > 0.005). Similarly, significant changes were observed in the decrease of ODI values after the procedure in both groups during the early postoperative period and the third week (P value < 0.05). However, no significant difference was observed in the ODI scores between the two groups.

CONCLUSIONS:

No significant difference was observed between betamethasone and methylprednisolone. Both steroid groups showed a substantial improvement in the preoperative pain scores of the patients.

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