更新于：2024-05-01

Vitiligo

白癜风

更新于：2024-05-01

基本信息

别名

Blotchy loss of skin color、Blotchy loss of skin colour、Hypopigmentation of skin

+ [16]

简介

A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.

关联

项与白癜风相关的药物

Ritlecitinib Tosilate

甲苯磺酸利特昔替尼

靶点

JAK3 x TEC

作用机制

JAK3抑制剂 [+1]

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2023-06-23

Melanocyte containing Human (Autologous) Epidermis-derived Cell Sheet

靶点-

作用机制-

在研机构

Japan Tissue Engineering Co., Ltd.

原研机构

Japan Tissue Engineering Co., Ltd.

在研适应症

白癜风

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期2023-03-17

Anifrolumab-FNIA

靶点

IFNAR-1

作用机制

IFNAR-1拮抗剂

在研机构

MedImmune Pharma BV [+6]

原研机构

MedImmune LLC

在研适应症

系统性红斑狼疮 [+7]

非在研适应症

类风湿关节炎

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2021-07-30

638

项与白癜风相关的临床试验

CTRI/2023/09/057189 / Not yet recruitingN/A

Randomized Controlled Trial Of Navayasarasayan Churna And Somaraji Churna In The Management Of ShwitraKustha With Respect To Vitiligo

开始日期2024-11-29

申办/合作机构-

NCT06068218 / RecruitingN/AIIT

Translational Assessment of Vitiligo According to Body Locations Translational Study

Vitiligo affects 0.5 to 2% of worldwide population and has a demonstrated impact on the quality of life.
Optimal treatment of vitiligo requires to target the auto-immune inflammatory response (to halt the depigmentation process), but also to induce the differentiation of melanocyte stem cells (to induce repigmentation). There is a well demonstrated discrepancy in the repigmentation response between anatomical areas of the body. Face and neck are the best responder with complete or almost complete repigmentation achieved in most cases under treatment. Trunk and limbs could have a complete or almost complete repigmentation in approximately half of the cases. The repigmentation is much more difficult in wrists, elbows, knees, proximal part of the hands. Finally, some areas such as the extremities of hands and feet, palms, soles, are almost impossible to repigment.
The investigator hypothesize that there are some factors that are produced in the skin that prevent (or at least decrease) the differentiation but also probably the migration and proliferation of melanocytes.
Primary objective To compare the mRNA expression of each types of cells in the skin of vitiligo patients compared to healthy volunteers according to body locations

开始日期2024-06-02

申办/合作机构

Centre Hospitalier Universitaire de Nice

NCT06327321 / Recruiting临床3期IIT

Vitiligo Treatment by Targeting TYK2 Mediated Responses Prospective Multicentric Double Blind Interventional Study

Vitiligo affects approximately 1 to 2% of the global population and significantly impacts people's quality of life. Achieving the best treatment outcomes for vitiligo involves addressing the autoimmune inflammatory response to stop the depigmentation process and promoting the differentiation of melanocyte stem cells to induce repigmentation. The loss of melanocytes in vitiligo is a result of an autoimmune process. While the IFN gamma pathway plays a crucial role in the adaptive immune response in vitiligo, there is increasing evidence highlighting the importance of the innate immune response. Deucravacitinib, an allosteric TYK2 inhibitor, has shown effectiveness and safety in treating psoriasis. It inhibits the responses of IFN alpha (IFNα), IFN beta (IFNβ), and IL12, and may also have an impact on the Th1 response. The hypothesis is that by targeting the IFN type I response and IL12, deucravacitinib could effectively halt the depigmentation process and facilitate repigmentation of vitiligo lesions. When combined with NB-UVB, the process of repigmentation should be significantly enhanced. The primary objective is to compare the proportion of patients treated with deucravacitinib versus placebo achieving VITIL-IA 50 at week 24.
Interventions Following central randomization, patients will be assigned to receive either deucravacitinib 12mg daily (QD) or a placebo daily (QD) for a duration of 24 weeks. At the end of this period, patients will be re-randomized to receive either deucravacitinib 12mg QD alone or deucravacitinib 12mg QD + twice weekly narrowband UVB treatment twice weekly for an additional 24 weeks.
Throughout the study, there will be a total of six visits conducted: selection, inclusion, Week 12, Week 24, Week 36, and Week 48. In patients who volunteer, a skin biopsy will be performed on both the lesional and peri-lesional areas at baseline, Week 12 and Week 36. Serum and plasma samples will be collected at the screening visit, Week 12, Week 24, Week 36, and Week 48.

开始日期2024-05-05

申办/合作机构

Centre Hospitalier Universitaire de Nice

100 项与白癜风相关的临床结果

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100 项与白癜风相关的转化医学

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0 项与白癜风相关的专利（医药）

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7,873

项与白癜风相关的文献（医药）

2024-12-01·The Journal of dermatological treatment

Efficacy and safety of 308-nm Excimer lamp combined with Tacrolimus 0.1% ointment vs Tacrolimus 0.1% ointment as monotherapy in treating children with limited vitiligo: a randomized controlled trial.

Article

作者: Diala Alshiyab ; Saleh A Ba-Shammakh ; Abdulqudos Al-Fakih ; Osama Tashman ; Danyah Sarakbi ; Firas Al-Qarqaz ; Jihan Muhaidat ; Ausama Atwan ; Michael J Cork

OBJECTIVE:

This study aims to assess the efficacy and safety of combining the 308-nm Excimer lamp with Tacrolimus 0.1% ointment, compared to Tacrolimus 0.1% ointment monotherapy, for treating pediatric vitiligo involving less than 10% of the body surface area.

METHODS:

Fifty pediatric patients with vitiligo were randomly assigned to two groups. Group A received Tacrolimus 0.1% ointment twice daily and Excimer light at 308-nm twice weekly, while Group B received Tacrolimus 0.1% ointment alone, administered twice daily. Repigmentation percentages were evaluated after 30, 90, and 180 days using the rule of nine.

RESULTS:

Group A exhibited a significant improvement in repigmentation, increasing from 10% after one month to 65% after six months. In contrast, Group B observed an increase from 10% to 30% over the same timeframe. The efficacy of the treatment was significantly higher in Group A at both the 3-month and 6-month follow-up points (p-value < .001). Moreover, Group A achieved notably higher repigmentation rates in the face, trunk, and lower limbs.

CONCLUSION:

The combination of Tacrolimus and the 308-nm excimer lamp yielded superior repigmentation results compared to Tacrolimus monotherapy in pediatric vitiligo patients. This combined approach may offer an effective new treatment protocol for pediatric vitiligo.

2024-12-01·The Journal of dermatological treatment

Comparison of various excimer laser (EL) combination therapies for vitiligo: a systematic review and network meta-analysis.

Review

作者: ChanXiu Li ; Yue Hu ; ZengYi Mu ; Lei Shi ; Xiao Sun ; XinYue Wang ; YaPing Wang ; XinHong Li

AIM:

This study aimed to compare the efficacy and safety of excimer laser (EL)-based combination regimens in improving repigmentation.

METHODS:

A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, and Embase on July 1, 2023, to include randomized controlled trials of EL combination treatments for vitiligo that met the criteria. The primary outcome measure was a repigmentation rate ≥ 75%, and the secondary outcome measures were a repigmentation rate of ≤ 25% and adverse events.

RESULTS:

Eleven studies involving 348 patients were included. Network Meta-Analysis showed that EL combined with antioxidants (SUCRA = 98.8%), EL combined with calcipotriol (SUCRA = 59.8%) and EL combined with tacalcitol (SUCRA = 59.6%) were the three optimal interventions achieving repigmentation rates ≥ 75%. EL alone (SUCRA = 77.6%), EL combined with tacalcitol (SUCRA = 61.7%) and EL combined with antioxidants (SUCRA = 57.2%) were the three interventions with the highest rates of treatment failure. Adverse events in all groups mainly included erythema, burning sensation and hyperpigmentation. Based on the results of the current study, EL combination therapies were safe with mild adverse events.

CONCLUSION:

EL combined with antioxidants was the preferred regimen for vitiligo, whereas EL alone was the regimen with the highest rate of treatment failure in vitiligo.

2024-12-01·The Journal of dermatological treatment

Vitiligo outpatient management in the United States: findings from the 2012-2019 National Ambulatory Medical care Survey (NAMCS).

Article

作者: Gaurav N Pathak ; Anurag N Pathak ; Vibha Mital ; Jimmy Dhillon ; Steven R Feldman ; Babar K Rao

437

项与白癜风相关的新闻（医药）

2024-04-08

·GBIHealth

年度收藏：跨国药企核心产品管线布局、研发进度-2023 H2（上篇）

引文跨国药企掌握着全球医药行业最强大的网络资源和决策智慧，他们用真金白银投票选择的方向有更大概率是较符合技术进步规律的（当然这既不意味着他们的决策一定正确、也不意味着这些决策能够被有效执行），通过对他们所有核心产品管线进行系统梳理并定期更新，就有助于我们系统性地了解在大药企自己的话语体系里，究竟哪些方向是在做的、有进展的、值得期待的，从而可以对判断到底什么是所谓“主流技术方向”有更全面直观的依据。本篇将为大家梳理礼来、诺和诺德、强生、默沙东、艾伯维五家企业的管线情况。在GLP-1横扫一切的强势驱动下，无论是业绩和市值，还是各自的产品布局，全球大药企都在经历深刻的变局，甚至可以说进行了颠覆性的重排，仅是下面这张摘要图与半年前相比就有不小的差异。- 左右滑动查看更多 -Lilly礼来礼来在2023年一骑绝尘成功登顶全球药企市值之冠，更夸张的是在2024年刚过两个月又从5,000多亿飚到7,000多亿，眼看就要冲着人类有史以来第一个万亿市值药企的壮举而去了。不过，这疯狂的市值还是有大幅预支未来成长之嫌，毕竟过往业绩虽然表现不俗，但也绝不是成倍的爆发式增长，且看未来是“预支”还是“透支”了。当然，礼来的业绩成长本身确实非常震撼，Tirzepatide在第一个完整销售年度豪取53亿美元、其中Q4单季24亿，在这种震古烁今的爬坡速度驱动下，礼来整体收入额一举从2022年的285亿跃升到2023年的341亿，而且仍处在继续向上跃升的过程中，2024年的业绩指引就是收入提升到410亿左右。- 左右滑动查看更多 -管线的攻城略地仍在发力：在万众瞩目的减肥线上，Tirzepatide肥胖适应症终于获批、并公布了MASH二期临床topline数据，Retatrutide和Orforglipron的多个三期临床先后启动；自免线上，Mirikizumab终于获批、并公布了CD三期临床结果，而Lebrikizumab却收到了FDA的CRL；Donanemab上市却意外地再次被推迟；肿瘤线上，Pirtobrutinib获批CLL/SLL适应症，从POINT收购来的核药PNT-2002也加入管线。- 左右滑动查看更多 -NOVO NORDISK诺和诺德诺和诺德在这波GLP-1狂潮中，市值从1,000亿飙升到接近6,000亿，与礼来呈一时瑜亮之势，在公司创立百年之际达到了可以说是从未有过的高度。看诺和诺德这十年以来的业绩成长，也确实配得上市值的提升。Semaglutide的三个品牌合计在2023年带来了近220亿美元销售额，不过近几个季度在GLP-1中的处方量市场份额已经开始走平，Tirzepatide迅速爬坡带来的竞争压力肉眼可见。- 左右滑动查看更多 -产能制约依然是严重瓶颈，特别是从2023年5月之后低剂量的供应出现明显的受限、以至于对国际市场还会实施供应量限制，从2024年1月开始逐渐增加供应能力，比起半年报时候“will remain restricted”的表述来看应该是有所缓解；产能扩建则继续加码，连续三年持续Capex翻倍的计划。- 左右滑动查看更多 -最重要的研发进展当然还属Semaglutide获批用于心血管风险保护、公布慢性肾病和HFpEF等三期临床结果，以及刚刚公布Amycretin一期的惊艳减重数据；其他值得关注的进展包括高草酸尿症RNAi疗法Nedosiran终于获批，Icosema完成三期临床，从中国药企KBP收购高血压资产等；瘦身也在持续，两个罕见病疗法Belcesiran和Eclipse先后消失在管线中。- 左右滑动查看更多 -J&J强生强生虽然业绩持续稳定，但市值近期下滑到4,000亿以下，被礼来与诺和诺德连续超车。强生医药板块的业绩在大药企中还是相当稳健，其中Ustekinumab和Daratumumab两大引擎的驱动力都非常充足，Guselkumab和Macitentan+Selexipag也表现不俗，但Ibrutinib、Infliximab、Abiraterone、Paliperidone等曾经的超重磅品种确实老态渐显。研发方面最突出的依然是在多发性骨髓瘤领域的“遮断性”优势，不过近期高歌猛进似有放缓，主要进展包括：Talquetamab获得欧盟批准；Teclistamab两周一次剂型获批；Daratumumab皮下剂型公布一线可移植MM患者的三期临床数据；Cilta-cel二线MM适应症获得欧盟积极意见；BCMA/CD3/GPRC5D三抗JNJ-5322公布一期临床数据。其他值得关注的进展包括：2019年从Taris收购来的新型膀胱内药物输送系统TAR-200/201分别公布了二期和一期数据；FcRn单抗Nipocalimab公布二期RA数据并获得FDA突破性认证；FGFR抑制剂Erdafitinib获得FDA完全批准并公布三期临床THOR2研究结果。管线新陈代谢正在进行，从收购Ambrx获得ARX-517/788等ADC资产，而RPGR AAV从管线中被拿掉。- 左右滑动查看更多 -MSD默沙东默沙东近期收入端依然表现稳健，K药仍在增长并稳住了药王地位（虽然刚上位没多久），HPV疫苗也增速不减，这两大定海神针填上了Molnupiravir急速缩水以及Sitagliptin专利悬崖带来的缺口，市值还是逼近3,000亿。研发进展中依然一大半都还是围绕K药的各种扩适应症和联用方案，近期主要进展包括：围手术期NSCLC的三期OS结果；获批1L HER2阴性胃癌和胆管癌等适应症；与mRNA-4157合作启动NSCLC辅助治疗的三期临床。其他重点值得关注的包括：与第一三共达成重大合作获得多个ADC管线，其中U3-1402已提交上市申请；HIF2α抑制剂Belzutifan获批2L RCC适应症；TIGIT单抗Vibostolimab公布与K药联用的NSCLC二期数据；肺炎疫苗V116和PAH药物Sotatercept提交上市申请；从科伦引进的TROP2 ADC、BTK C481S抑制剂Nemtabrutinib、CYP11A1抑制剂和LSD1抑制剂MK-5684Bomedemstat等启动三期临床。此外，收购Harpoon获得的DLL3/CD3/Albumin三抗加入管线，而P2X3慢性咳嗽药物Gefapixant则再次收到CRL。- 左右滑动查看更多 -Abbvie艾伯维2023年以来，Adalimumab和Ibrutinib两大超重磅受竞争者的挤压销售额开始出现大幅下滑，所幸Risankizuma、Upadacitinib、Venetoclax、Cariprazine几个新生代贡献一定的增量，整体业绩才算没有太崩坏，因此市值基本上还是稳定在2,500亿上下。眼看着业绩支撑轴在发生更迭，艾伯维将Risankizumab和Upadacitinib的峰值预期提高到170亿和100亿以上，试图再造一个Adalimumab时代的免疫帝国。- 左右滑动查看更多 -管线方面同样是在经历重心的迁移：免疫线逐渐收缩到围绕现有重磅的适应症扩展，近期包括Risankizumab公布与Ustekinumab在CD适应症的头对头三期临床结果、Upadacitinib公布白癜风二期临床结果，此外IL-1α/β双抗Lutikizumab公布化脓性汗腺炎二期临床结果，另有SCF248、IL-2、GLP-2等新机制加入管线；肿瘤线进展包括收购Immunogen并获得多个ADC资产，CD20×CD3双抗Epcoritamab获得欧盟批准并向FDA提交末线FL的上市申请，Teliso-V公布NSCLC二期临床数据，同时补充了大批新项目进入管线；神经/精神线进展较多，帕金森复方药物ABBV-951提交上市申请，偏头痛药物Atogepant和Ubrogepant分别提交预防适应症的上市申请和公布前兆适应症的三期临床数据，此外通过87亿巨额收购Cerevel补充多个AD/PD管线。- 左右滑动查看更多 -数据声明本文选取截至2023年12月31日市值超过1,000亿美元的制药企业，共11家。已上市产品包括收入贡献较大的（年销售额10亿美元以上）、尚在增长或稳定期的（获批10年以上的基本不考虑）和仍在积极开发阶段的（正在进行重要适应症扩展的临床试验）；临床在研管线以年报季报的研发进度更新章节、研发日及重要会议展示材料和公司日常信息披露等取并集，故可以理解为公司自己认为当前优先级较高的管线，而并不覆盖全体管线。主要梳理信息包括近几个季度的市值和收入利润变化（多主业公司只取制药板块）、半年内最重要的审批进展和临床数据发布、以及未来近期的重要里程碑。\ | /★联系我们投稿 | 发稿 | 媒体合作▶ sylvia.hua@generalbiologic.com数据库 | 咨询服务 | 资讯追踪▶ 点击左下“阅读原文”完成表单填写点击阅读原文订阅全球行业新闻

临床3期并购

2024-04-06

·米内网

热销抗感染注射剂或致癌！19个品种集采结果出炉，知名药企遭停产，中药新药大爆发

看点view本周，医疗反腐风暴持续，市卫健委主任接连被查；药品市场迎变局，4款中成药“处转非”，19个药品集采结果出炉，63个药品主动降价；药企大新闻，中药企业创始人辞职，知名药企遭停产停业；研发新进展，$200亿“神药”国产首个冲刺，中药新药大爆发；资本市场新动态，知名药企或退市，本土Biotech被收购……医药行业一周大事件，精彩不容错过！米内一周TOP榜药企动态中药OTC龙头厉害了！独家品种大涨67%人福爆发了！神经系统用药大卖85亿创新高米内数据11个独家儿科中成药亮眼！葵花、健民领跑突破600亿！网上药店TOP20：10亿品牌诞生短缺药热浪不断！超10亿重磅频频上榜审评药闻广东药企1类新药来袭！猛攻1700亿市场康缘入局15亿大品种齐鲁抢首仿，剑指亿级抗帕金森氏病药市卫健委主任接连被查4月2日，湖南纪检监察网发布公告，湖南省娄底市卫生健康委员会党组书记、主任易军波涉嫌严重违纪违法，目前正接受娄底市纪委监委纪律审查和监察调查。此前（3月28日），据安徽纪检监察网，芜湖市卫生健康委员会党委书记、主任秦正华涉嫌严重违纪违法，目前正接受芜湖市纪委监委纪律审查和监察调查。（米内网整理）4款中成药“处转非”4月1日，国家药监局发布公布，灵莲花颗粒、丹栀逍遥胶囊、秋水健脾散、胃舒宁片4款中成药由处方药转换为非处方药。其中，灵莲花颗粒为佐力药业独家品种，丹栀逍遥胶囊为陕西方舟制药独家品种，秋水健脾散为泉州中侨药业独家品种，胃舒宁片有辽宁华润本溪三药和陕西康惠制药2家企业获得生产批文。（米内网整理）抗感染注射剂存在潜在致癌风险4月1日，国家药监局发布公告，修订替硝唑注射剂说明书，在其说明书增加“黑框警告”：本品存在潜在的致癌风险。在另一种硝基咪唑类药物——甲硝唑对大鼠和小鼠的长期性治疗试验中发现其有致癌性。虽然在替硝唑试验中未见有类似的数据报道，但是这两种药物有结构关联性，并具有类似的生物学效应。本品应仅限用于治疗批准的适应症。避免长期使用。（国家药监局）米内数据：近年来中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院（简称中国公立医疗机构）终端替硝唑注射剂销售额均超1亿元。63个药品主动降价4月1日，四川省药械招标采购服务中心发布通知，根据企业提交的药品降价申请，拟调低部分药品的联动参考价格。经梳理，共有63个药品（以序号计）在列，涉及瑞阳制药、济川药业、康缘药业、倍特药业等多家企业，其中有12个为中成药，喀什昆仑维吾尔药业的玫瑰花口服液等降幅超过70%。（米内网整理）19个品种！大联盟集采结果出炉4月1日，江苏省医保局发布通知，公示江西牵头的十六省（区）联盟药品集中带量采购中选结果。19个品种（以药品名称计）产生30个中选产品（以药品名+规格计），涉及石药集团、倍特药业、青岛双鲸药业等20余家药企。从产品中选企业数看，注射用法莫替丁、注射用氨甲苯酸、注射用美洛西林钠、注射用硫普罗宁等为独家中选。（江苏省医保局）延伸阅读：十六省（区）联盟包括江西、吉林、黑龙江、安徽、河南、湖北、广西、四川、贵州、云南、西藏、陕西、青海、宁夏、新疆和新疆生产建设兵团，其中江西、安徽、河南、湖北、四川、陕西等体量都不小。超$200亿“神药”！国内首个生物类似药报产4月3日，CDE网站显示，九源基因的生物类似药司美格鲁肽注射液上市申请获得受理，用于成人2型糖尿病患者的血糖控制。司美格鲁肽是由诺和诺德开发的一款长效GLP-1（胰高血糖素样肽-1）受体激动剂，2023年全球销售额合计超过200亿美元，包括皮下注射制剂Ozempic（957.18亿丹麦克朗），片剂Rybelsus（2型糖尿病，187.5亿丹麦克朗），注射剂Wegovy（肥胖，313.43亿丹麦克朗）。（米内网整理）延伸阅读：国内有多家企业加入司美格鲁肽生物类似药开发的竞赛，除了九源基因率先递交上市申请外，齐鲁制药、华东医药、丽珠医药、联邦制药、惠升生物、正大天晴、石药集团等公司均已将产品推至III期临床。中药新药大爆发！2500亿市场掀热潮4月3日，国家药监局官网显示，华润三九（雅安）药业的中药3.1类新药苓桂术甘颗粒获批上市，这是一款古代经典名方中药复方制剂；4月2日，中国科学院新疆理化技术研究所提交的中药1.1类新药司亚丹凝胶的临床申请获得受理，这是一款用于治疗白癜风的外用制剂；苏中药业的痔瘘熏洗颗粒、江苏中雍红瑞制药的香术平胃散2款中药1.1类新药获得临床试验默示许可，分别用于混合痔术后症状改善、慢性非萎缩性胃炎脾胃虚寒证。（米内网整理）延伸阅读：近年来，鼓励中医药创新发展的政策不断，药品审评审批等制度的改革加速中药新药上市，中成药市场空间将逐步打开。米内网数据显示，2022年中国公立医疗机构终端中成药销售规模超过2500亿元。未遵守GMP！一药企遭罚款50万、停产停业4月1日，云南省药监局发布2024年行政处罚信息公开表（第4部分），云南金柯制药有限公司在中药饮片生产活动中未遵守《药品生产质量管理规范》，被罚款50万元并责令停产停业整顿。（医药慧）18亿美元！又一家本土Biotech被收购被收购的中国Biotech又多了一个，这次热钱流向了ADC。4月3日，丹麦药企Genmab与普方生物达成一项最终协议，Genmab将以18亿美元全现金交易的方式收购普方生物。作为一家中国本土Biotech，普方生物主要开发用于治疗某些癌症（包括卵巢癌和其他表达FRα的实体瘤）的下一代ADC和ADC技术。（健识局）延伸阅读：近年来，本土Biotech逐渐受到海外药企的青睐：2023年底，细胞治疗领域的明星公司亘喜生物，成为首家被MNC全资买下的本土Biotech；2024年1月，诺华宣布全资收购信瑞诺医药，加速其在肾脏疾病领域的布局；2024年3月，美国Nuvation Bio称，对葆元医药的收购交易预计在今年第二季度完成。知名中药企业创始人辞职4月2日，红日药业发布一则公司高管变动公告：姚小青因个人工作原因申请辞去公司法定代表人、董事长、董事等职务，辞职后不再担任公司任何职务。同时，经公司董事会提名委员会审核无异议并提名，选举吴文元、蓝武军分别为公司第八届董事会董事长、副董事长。此前（3月12日），红日药业副董、董事、总经理郑丹因退休离任。（公司公告）延伸阅读：红日药业是中药配方颗粒国家试点中6家企业之一，中药配方颗粒为公司的主营业务，2023年收入占比接近50%。华润三九原总裁获国药集团高管任命4月1日，中国医药集团有限公司（国药集团）宣布一项重大人事任命，赵炳祥任中国医药集团有限公司党委副书记、董事，提名为中国医药集团有限公司总经理人选。在被提名为国药集团总经理之前，赵炳祥为华润三九总裁。从过往的履历看，赵炳祥在医药销售、中药业务、企业转型上拥有较丰富的经验。（赛柏蓝）知名企业或退市近日，景峰医药公告称，经公司财务部门初步测算，预计2023年度期末净资产为-6000万元至-3000万元。根据《深圳证券交易所股票上市规则》规定，公司股票交易将在2023年年度报告披露后被实施退市风险警示。（公司公告）注：米内网《中国公立医疗机构药品终端竞争格局》，统计范围是：中国城市公立医院、县级公立医院、城市社区中心以及乡镇卫生院，不含民营医院、私人诊所、村卫生室；上述销售额以产品在终端的平均零售价计算。投稿及报料请发邮件到872470254@qq.com稿件要求详询米内微信首页菜单栏商务及内容合作可联系QQ：412539092【分享、点赞、在看】点一点不失联哦

带量采购高管变更并购一致性评价

2024-04-05

·PRNewswire

AMERICAN SKIN ASSOCIATION SPRING GALA CELEBRATES OUTSTANDING HONOREES

Gala honors Pioneer in Dermatology, Emma Guttman-Yassky, MD, PhD and Global Pharmaceutical Leader Eli Lilly and Company NEW YORK, April 5, 2024 /PRNewswire/ -- On Thursday evening, at The Plaza Hotel, American Skin Association (ASA) held their Spring Gala. They presented awards to two outstanding honorees and celebrated another successful year of funding research and educating youth on skin health. The gala was attended by ASA's loyal supporters and donors, including philanthropists, business leaders, and renowned physicians from the field of dermatology. Howard P. Milstein, Chairman of ASA, said, "ASA is proud to present Dr. Emma Guttman-Yassky and Eli Lilly and Company these much-deserved awards for their dedication to the field of dermatology. Both Dr. Guttman-Yassky and Lilly share in our mission and we look forward to continuing to partner as we work towards finding cures for skin diseases." This year, awards were presented to the following: Emma Guttman-Yassky, MD, PhD, System Chair of the Department of Dermatology at the Icahn School of Medicine at Mount Sinai, was presented ASA's Inaugural Therapeutic Innovation Award for her tireless work towards discovering new dermatological therapies which bring hope to patients. The award was presented by ASA Chairman, Howard P. Milstein, who praised Dr. Guttman-Yassky's continuing dedication to dermatological research, her care for patients, and her mentorship of the next generation of dermatologists. She is one of the world's leading experts in inflammatory skin diseases and the first woman to chair a dermatology department in New York. Global pharmaceutical leader, Eli Lilly and Company, received ASA's 2024 Distinguished Corporate Leadership Award. The award was presented by Mark G. Lebwohl, MD and was accepted by Lilly's Head of Dermatology Global/US Medical Affairs, Maria Jose Rueda, MD. Eli Lilly and Company has a nearly 150-year legacy of pioneering life-changing discoveries. Dr. Lebwohl shared that the company is committed to delivering innovative clinical trials that reflect the diversity of our world and continue to work to ensure their medicines are accessible and affordable. Their status as a leading, global medicine company turning science into healing to make life better for more than 51 million people around the world, was applauded. "I congratulate Dr. Guttman-Yassky and Eli Lilly and Company on their honors this evening. We look forward to continuing our long-standing work with physicians like Dr. Guttman-Yassky and organizations like Lilly as we work together to provide hope to patients and their families," said President of ASA, Dr. David A. Norris. For nearly four decades, ASA and its affiliates have funded over $50 million in grants to support the work of more than 300 promising young scientists. Recipients, who work on breakthrough efforts to prevent, detect, and treat skin cancer and other skin diseases, have gone on to become top researchers in dermatology. The critical research funded by ASA addresses not only the causes and treatments of melanoma, vitiligo, psoriasis, atopic dermatitis, and other skin diseases, but also promises remarkable breakthroughs in the search for long-sought-after cures. ASA's educational mission is no less crucial. The organization continues to support the SPOTS (Sun Protection Outreach Teaching by Students) program, a free community outreach program designed to teach students from preschool through high school about the importance of early detection and prevention of skin cancer. ASA's educational contributions are part of a growing worldwide understanding of the importance of skin health awareness. The event's Master of Ceremonies was NBC's Emmy-winning weather anchor Dave Price. Mr. Price has emceed the event in previous years and was once again a wonderful addition to the festivities. ABOUT AMERICAN SKIN ASSOCIATION A unique collaboration of patients, families, advocates, physicians and scientists, ASA has evolved over nearly four decades as a leading force in efforts to defeat melanoma, skin cancer and other skin diseases. Established as a 501(c)(3) organization to serve the now more than 100 million Americans – one-third of the U.S. population – afflicted with skin disorders, the organization's mission remains to: advance research, champion skin health – particularly among children, and drive public awareness about skin disease. For more information, visit americanskin.org. American Skin Association has earned Candid's 2023 Seal of Platinum Transparency and Four-Star Rating from Charity Navigator. SOURCE American Skin Association