当归提取物(Angelica sinensis) - _专利_临床

概要

基本信息

药物类型

中药

别名

Angelica sinensis extract

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Singapore General Hospital Pte Ltd.

在研机构-

非在研机构

Singapore General Hospital Pte Ltd.

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

3

项与当归提取物相关的临床试验

ITMCTR2024000284 / CompletedIIT

Efficacy and safety of Angelica and Safflower Spot Removal Essence for Melasma: A clinical trial

开始日期2022-09-01

申办/合作机构-

NCT02008981 / Completed临床3期IIT

A Randomized, Double Blind, Placebo-controlled Crossover Study on the Effect of Commonly Used Herbal Products on Platelet Function and Coagulation Profile of Healthy Volunteers

This is a research study on the effect of some commonly used "blood activating" herbal products on platelet function and coagulation profile, ie whether it causes an increase in bleeding tendency, either used alone or in combination with Aspirin which is a commonly used anti-platelet drug.

开始日期2013-12-01

申办/合作机构

Singapore General Hospital Pte Ltd.

[+1]

NCT00199485 / Completed临床4期IIT

Angelica Sinensis for the Treatment of Hot Flashes in Men Undergoing Androgen Deprivation Therapy for Prostate Cancer

Men undergoing androgen deprivation therapy for prostate cancer may experience significant side effects including symptoms of intense heat, facial flushing, and sweating. These so-called hot flashes are similar to those experienced by women during menopause. A traditional Chinese herbal preparation, Dong Quai, has been used for thousands of years to reduce the incidence and severity of hot flashes. Anecdotal evidence exists to support the use of Dong Quai in men treated with androgen deprivation therapy for prostate cancer.
Recently, the awareness and use of herbal remedies and over-the-counter preparations for a number of different conditions have increased dramatically. This trial was, therefore, designed to determine if Dong Quai significantly reduces the incidence and severity of hot flashes in men following androgen deprivation therapy for prostate cancer.

开始日期2002-10-01

申办/合作机构

Lawson Health Research Institute

[+1]

100 项与当归提取物相关的临床结果

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100 项与当归提取物相关的转化医学

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100 项与当归提取物相关的专利（医药）

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132

项与当归提取物相关的文献（医药）

2024-12-01·International Journal of Biological Macromolecules

Angelica sinensis polysaccharides mitigate cadmium-induced apoptosis in layer chicken chondrocytes by inhibiting the JNK signaling pathway

Article

作者: Bian, Jianchun ; Gu, Jianhong ; Wang, Panting ; Zhou, Jiatao ; Wang, Guoshuai ; Liu, Xuezhong ; Xia, Han ; Zou, Hui ; Zhao, Xinrui ; Yuan, Yan ; Liu, Zongping ; Tong, Xishuai

Cadmium (Cd), a toxic heavy metal pollutant, inflicts widespread damage on various organs and tissues, including cartilage, where it induces chondrocyte apoptosis. Angelica sinensis polysaccharides (ASP), a key active component of the traditional Chinese medicine Angelica sinensis, have been shown to possess anti-apoptotic effects on chondrocytes. This study investigates the in vitro effects of ASP on alleviating Cd-induced apoptosis in layer chicken chondrocytes, focusing on the mitochondrial apoptosis pathway mediated by the c-Jun N-terminal kinase (JNK) signaling pathway. Chondrocytes were isolated from layer chicken embryos and confirmed to express collagen type II alpha 1 (Col2a1). We found that Cd triggered apoptosis in the chondrocytes; however, the use of the JNK inhibitor SP 600125 mitigated mitochondrial structural damage casused by Cd, indicating the involvement of JNK signaling in this process. Furthermore, ASP effectively alleviated Cd-induced apoptosis in layer chicken chondrocytes by inhibiting JNK signaling in vitro. Our findings provide a theoretical foundation for the clinical application of ASP in preventing Cd-induced cartilage diseases in poultry.

2024-10-01·Journal of Molecular Histology

Angelica sinensis polysaccharides promote extramedullary stress erythropoiesis via ameliorating splenic glycolysis and EPO/STAT5 signaling-regulated macrophages

Article

作者: Wang, Cheng ; Liu, Yafei ; Sun, Nianci ; Wang, Yaping ; Wang, Ziling ; Jiang, Honghui ; Wang, Biyao ; Yang, Ting ; Wang, Lu ; Huang, Caihong ; Du, Kunhang

Conventional treatments exhibit various side effects on chronic stress anemia. Extramedullary stress erythropoiesis is a compensatory mechanism, which may effectively counteract anemia. Angelica sinensis polysaccharides (ASP) are the main active ingredient found in Angelica sinensis and exhibit antioxidant and hematopoietic effects. However, the effects of ASP on extramedullary stress erythropoiesis remain to be unclear. Here, we demonstrated the protective effects of ASP on chemotherapeutic drug 5-fluorouracil (5-FU)-induced decline in peripheral blood parameters such as RBC counts, HGB, HCT, and MCH, and the decline of BFU-E colony enumeration in the bone marrow. Meanwhile, ASP promoted extramedullary erythropoiesis, increasing cellular proliferation in the splenic red pulp and cyclin D1 protein expression, abrogating phase G0/G1 arrest of c-kit⁺ cells in mouse spleen. RT-qPCR and immunohistochemistry further revealed that ASP increased macrophage chemokine Ccl2 genetic expression and the number of F4/80⁺ macrophages in the spleen. The colony-forming assay showed that ASP significantly increased splenic BFU-E. Furthermore, we found that ASP facilitated glycolytic genes including Hk2, Pgk1, Pkm, Pdk1, and Ldha via PI3K/Akt/HIF2α signaling in the spleen. Subsequently, ASP declined pro-proinflammatory factor IL-1β, whereas upregulating erythroid proliferation-associated genes Gdf15, Bmp4, Wnt2b, and Wnt8a. Moreover, ASP facilitated EPO/STAT5 signaling in splenic macrophages, thus enhancing erythroid lineage Gata2 genetic expression. Our study indicated that ASP may improve glycolysis, promoting the activity of splenic macrophages, subsequently promoting erythroid progenitor cell expansion. Additionally, ASP facilitates erythroid differentiation via macrophage-mediated EpoR/STAT5 signaling; suggesting it might be a promising strategy for stress anemia treatment.

2024-06-01·Biomedicine & Pharmacotherapy

Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4

Article

作者: Tong, Yunshun ; Zhao, Xinyao ; Zheng, Ruxin ; Gu, Yuze ; Guo, Weikang ; Wang, Wanyue ; Yang, Mengdi ; Wang, Yaoxian ; Lei, Fei

Cisplatin (DDP) resistance poses a significant challenge in the treatment of ovarian cancer. Studies have shown that the combination of certain polysaccharides derived from plants with DDP is an effective approach to overcoming drug resistance in some cancers. Angelica sinensis (Oliv.) Diels has been used for centuries in China to treat gynecological ailments. Numerous studies indicate that Angelica sinensis polysaccharide (ASP), an extract from Angelica sinensis, can inhibit various forms of cancer. However, the impact of ASP on ovarian cancer remains unexplored. Through both in vitro and in vivo experiments, our study revealed the capability of ASP to effectively reversing DDP resistance in cisplatin-resistant ovarian cancer cells, while exhibiting acceptable safety profiles in vivo. To elucidate the mechanism underlying drug resistance reversal, we employed RNA-seq analysis and identified GPX4 as a key gene. Considering the role of GPX4 in ferroptosis, we conducted additional research to explore the effects of combining ASP with DDP on SKOV3/DDP cells. In summary, our findings demonstrate that the combination of ASP and DDP effectively suppresses GPX4 expression in SKOV3/DDP cells, thereby reversing their resistance to DDP.

100 项与当归提取物相关的药物交易

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研发状态

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASN2013	N/A	-	-	H2O2 alone	憲範蓋艱願鬱淵窪簾餘(鏇鏇夢築醖構窪衊鹹觸) = 範壓窪製夢繭淵憲獵鏇蓋鏇遞廠衊衊鹽繭艱窪 (夢窪憲鏇遞淵範鹹選襯 )	-	2013-11-05
				Angelica Sinensis	憲範蓋艱願鬱淵窪簾餘(鏇鏇夢築醖構窪衊鹹觸) = 獵鬱鹹醖憲鑰淵選積壓蓋鏇遞廠衊衊鹽繭艱窪 (夢窪憲鏇遞淵範鹹選襯 )