6-AN(6-AN) - 药物靶点：PGD_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

PGD

作用机制

PGD inhibitors(phosphogluconate dehydrogenase inhibitors)

治疗领域-

在研适应症-

非在研适应症-

原研机构

The University of Melbourne USA Foundation

在研机构-

非在研机构-

最高研发阶段-

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 6-AN 相关的临床结果

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100 项与 6-AN 相关的转化医学

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100 项与 6-AN 相关的专利（医药）

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2

项与 6-AN 相关的文献（医药）

Journal of Materials Chemistry B

Engineering hypoxia-responsive 6-aminonicotinamide prodrugs for on-demand NADPH depletion and redox manipulation

Article

作者: Zhang, Baoxin ; Zhao, Yanjun ; Dong, Yuyu ; Dai, Yujie ; Li, Mingye ; Wang, Zheng

Targeting G6PD via the hypoxia-responsive prodrugs.

Journal of Agricultural and Food Chemistry

Design, Synthesis, and Herbicidal Activities of N-(5-(3,5-Methoxyphenyl)-(thiazole-2-yl))phenoxyacetamide Derivatives

Article

作者: Li, Zuren ; Bai, Lianyang ; Han, Jincai ; Bai, Haodong ; Li, Hao ; Luo, Dingfeng ; Bai, Zhendong ; Liu, Na ; Wan, Yuanhui ; Wang, Yingying

Thiazole and phenoxyacetic acid are key moieties in many natural and synthetic biologically active agents. A series of N-(5-(3,5-methoxyphenyl)-(thiazole-2-yl))phenoxyacetamide derivatives 6an-6bd were designed and synthesized, and their structures were confirmed by NMR and HRMS. Most of derivatives exhibited superior inhibition of Echinochloa crusgalli (E.c.) and Lactuca sativa (L.s.) seed germination by the Petri dish bioassay. Indeed, herbicidal bioassays indicated that 6an (2-(2,4-dichlorophenoxy)-N-(5-(3,5-dimethoxyphenyl)-1,3,4-thiadiazol-2-yl)acetamide) had the best inhibition against L.s. (IC₅₀ = 42.7 g/ha, 375 g/ha at field experiments). 6an also had no harmful effect on Zea mays at 2- to 4-fold field usage. Moreover, transcriptomics and metabolomics analysis showed that 6an significantly influenced cell metabolism, including galactose metabolism and ascorbate and aldarate metabolism. These discoveries highlight that 6an shows promise to be developed as a potential herbicide.

100 项与 6-AN 相关的药物交易

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