VM-44866(VM-44866) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域

感染

在研适应症-

非在研适应症

蠕虫病

原研机构

GSK Plc

在研机构-

非在研机构

GSK Plc

最高研发阶段无进展临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C34H48O8

InChIKeyHSLQALAXKYULNJ-JGQPNSKLSA-N

CAS号115021-83-5

关联

100 项与 VM-44866 相关的临床结果

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100 项与 VM-44866 相关的转化医学

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100 项与 VM-44866 相关的专利（医药）

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2

项与 VM-44866 相关的文献（医药）

1990-01-01·The Journal of Antibiotics4区 · 医学

A novel series of milbemycin antibiotics from Streptomyces strain E225. II. Isolation, characterization, structure elucidation and solution conformations.

4区 · 医学

Article

作者: M. E. Poulton ; J. R. Everett ; R. J. J. Dorgan ; G. H. Baker ; J. D. Hood

A novel series of milbemycin antibiotics were isolated from the fermentation broth of a Streptomyces species designated E225. The structures of the four main metabolites VM 44857 (1), VM 44864 (2), VM 44865 (3) and VM 44866 (4) were determined by NMR techniques. In addition we describe the solution conformations of the major metabolite VM 44857 (1).

1989-01-01·The Journal of Antibiotics4区 · 医学

A novel series of milbemycin antibiotics from Streptomyces strain E225. I. Discovery, fermentation and anthelmintic activity.

4区 · 医学

Article

作者: Poulton, M. E. ; Brewer, M. D. ; Hood, J. D. ; Banks, R. M. ; Fish, J. P. ; Manger, B. R.

A novel series of milbemycin antibiotics were produced by soil isolate, strain E225 which was shown to be a Streptomyces species. The antibiotics displayed anthelmintic activity against Trichostrongylus colubriformis in the gerbil. Two of the compounds, VM 44857 and VM 44866 were shown to be potent anthelmintics against mixed nematode infections in sheep.

100 项与 VM-44866 相关的药物交易

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