The effect of proactive therapy with tacrolimus and betamethasone butyrate on atopic dermatitis: Randomized placebo-controlled study - The effect of proactive therapy on atopic dermatitis: Randomized placebo-controlled study

开始日期2011-12-01

申办/合作机构-

100 项与倍他米松丁酸丙酸酯相关的临床结果

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100 项与倍他米松丁酸丙酸酯相关的转化医学

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100 项与倍他米松丁酸丙酸酯相关的专利（医药）

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677

项与倍他米松丁酸丙酸酯相关的文献（医药）

2025-01-01·Current Problems in Cardiology

Associations between central and brachial blood pressure in patients with hypertension and aortovascular disease: Implications for clinical practice

Review

作者: Proietti, Riccardo ; Field, Mark ; Lip, Gregory Y.H. ; Alsomali, Abdulghafoor ; Lip, Gregory Y H ; Leo, Donato ; Akhtar, Riaz ; Grillo, Andrea ; Tidbury, Nicola

Central blood pressure (CBP) measurements, compared to brachial blood pressure (bBP), offer a superior predictive accuracy for aortovascular disease outcomes. This emphasises the distinctiveness of central hemodynamic metrics such as CBP, measuring the pressure directly exerted from the cardiac muscle to the major arteries, and provides a more direct assessment of cardiovascular workload than bBP, which measures the pressure against peripheral artery walls. This review synthesises findings evaluating the correlation between CBP and key aortovascular disease markers. Thoracic aortic aneurysm (TAA) growth is a crucial aspect of aortovascular assessment. CBP more accurately correlates with arterial stiffness (AS), the growth of TAA, and cardiovascular diseases, offering a more dependable prediction of aortovascular diseases, adverse cardiovascular events (CVE) and organ damage compared to bBP. The incorporation of CBP into routine clinical practice could enhance aortovascular assessments and therapeutic strategies when compared to bBP, particularly through a deeper understanding of aortic wave dynamics, which could fundamentally alter aortovascular diagnostics and treatment. In conclusion, integrating CBP into aortovascular and cardiovascular risk management is encouraged. Further research is necessary to substantiate these aspects and explore the operative implications of CBP in clinical settings.

2024-12-01·Science of The Total Environment

Butyl benzyl phthalate induces neurotoxicity in Eisenia fetida: Mechanisms revealed by biochemical and metabolomic analyses

Article

作者: Liu, Wanjing ; Zhang, Lanlan ; Zhu, Lusheng ; Gao, Peng ; Wang, Jun ; Pei, Mengyuan ; Chen, Xi ; Yao, Mengyao ; Yue, Zhengfu ; Lei, Shuhan ; Zhang, Cheng ; Xu, Ying

Phthalates, particularly butyl benzyl phthalate (BBP), are ubiquitous environmental contaminants with potential neurotoxic effects. However, their impact on soil organisms, especially earthworms (Eisenia fetida), remains poorly understood. The current study investigated the neurotoxic effects of BBP on Eisenia fetida in artificial and red soils using an integrated approach combining biochemical assays, metabolomics, and molecular docking. Earthworms were exposed to 0, 1, and 10 mg kg^-1 BBP for 14 and 28 days. Biochemical assays revealed significant increases in oxidative stress markers and disruptions in neurotransmission-related enzyme activities. Metabolomic analysis of the cerebral ganglia identified alterations in energy metabolism, lipid metabolism, and neuroactive ligand-receptor interaction signaling pathways. Molecular docking studies corroborated these findings, showing strong interactions between BBP and essential neuronal proteins, particularly the sodium pump. The integration of these data suggests that BBP-induced neurotoxicity in Eisenia fetida is primarily mediated by calcium signaling pathway dysfunction and calcium homeostasis imbalance. Notably, neurotoxic effects were more pronounced in red soil than in artificial soil, highlighting the importance of considering soil type in ecotoxicological assessments. The current study provides novel insights into the mechanisms of BBP-induced neurotoxicity in soil invertebrates and underscores the potential ecological risks associated with phthalate contamination in agricultural environments.

2024-12-01·Food Chemistry

Development and characterization of wax–bovine bone protein-grapeseed oil composite oleogels: Experimental and molecular simulation studies

Article

作者: Chen, Jingya ; Ran, Cenchen ; Shi, Wenjing ; Dong, Juan ; Cui, Haotian ; Wang, Qingling ; Li, Yangyang ; Lu, Shiling ; Diao, Kui

Three new types of composite oleogel formulations were designed. Specifically, oleogels were prepared using 90% grapeseed oil as the oil phase and carnauba wax (CW)/beeswax/rice bran wax-bovine bone protein (BBP) as gelators. All samples were solid and had an oil-binding capacity of >90%. BBP addition considerably improved the waxy texture of the oleogel and had an important effect on the crystalline network. X-ray diffractometry indicated that BBP increased the β'-crystal content. All samples showed sol-gel thermodynamic behavior under temperature scanning. Fourier-transform infrared spectroscopy and molecular docking confirmed the formation of noncovalent interactions dominated by van der Waals forces during the development of the oleogel. The optimal components of the three oleogels exhibited an excellent effect of slowing down the release of free fatty acids. This study could serve as a reference for the development and application of wax-protein as a new binary gelator in the food industry.

100 项与倍他米松丁酸丙酸酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D02032	-	D07XC01 A07EA04 R01AD06 C05AA05 S03BA03 S01CB04 S01BA06 D07AC01 H02AB01 S02BA07 R03BA04	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
银屑病	日本	-	1995-01-03
皮肤增生性瘢痕	-	-	-
湿疹	-	-	-
红斑	-	-	-
皮疹	-	-	-
脂溢性角化病	-	-	-
扁平苔藓	-	-	-
盘状红斑狼疮	-	-	-
蕈样真菌病	-	-	-
大疱性类天疱疮	-	-	-
痒疹	-	-	-
结节病	-	-	-

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


MLB-01-003 (MDA2022)	临床2期	肢带型肌营养不良2I型 creatine kinase (CK)	14	BBP-418 6g daily	(網廠蓋網衊膚築壓獵蓋) = No drug-related SAEs have occurred 製顧鹽蓋鏇鹽構糧鏇鏇 (醖選窪獵壓鏇窪襯淵膚 )	积极	2022-03-13
				BBP-418 6g twice daily