二十二醇(Docosanol) - 药物靶点：Viral fusion proteins_在研适应症：单纯疱疹_专利_临床

概要

基本信息

药物类型

小分子化药

别名

1-Docosanol、Abrax、Behenic alcohol

+ [18]

靶点

Viral fusion proteins

作用机制

病毒融合蛋白抑制剂

治疗领域

在研适应症

非在研适应症

原研机构

在研机构

Haleon US Capital LLCGlaxoSmithKline Consumer Healthcare Ltd.

非在研机构

Laboratoire Boreaderme Inc.

最高研发阶段批准上市

首次获批日期

美国 (2000-07-25),

单纯疱疹

最高研发阶段(中国)批准上市

特殊审评-

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结构

分子式C22H46O

InChIKeyNOPFSRXAKWQILS-UHFFFAOYSA-N

CAS号661-19-8

关联

2

项与二十二醇相关的临床试验

NCT00467662 / Unknown status临床4期IIT

The Safety, Efficacy and Convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.

Recurrent cold sores - herpes simplex labialis (HSL) occurs in 20-40% of the US population and patient seek treatment because of the discomfort and visibility of the lesion although it is a self limiting disease. The purpose of this study is to check the safety, Efficacy and convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.

开始日期-

申办/合作机构

Hadassah University Hospital

NCT03977792 / Unknown status临床2期

A Randomized, Open Label, Non-inferiority Study to Compare the Safety and Efficacy of BOR15001L7 to Docosanol 10% in Patients With Recurrent Herpes Labialis

BOR15001L7 is a natural product. The primary objective of this study is to demonstrate its non-inferiority to docosanol 10% based on the healing time of cold sores in patients with recurrent herpes labialis.

开始日期2020-09-01

申办/合作机构

Laboratoire Boreaderme Inc.

100 项与二十二醇相关的临床结果

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100 项与二十二醇相关的转化医学

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100 项与二十二醇相关的专利（医药）

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108

项与二十二醇相关的文献（医药）

2024-10-01·iScience

Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway

Article

作者: Liu, Kerong ; Cheng, Jie ; Zhang, Le ; Gu, Ying ; Chen, Sha ; Cao, Minkai ; Pan, Xingnan

Gestational diabetes mellitus (GDM) is a distinct form of diabetes that poses a significant threat to the health of both pregnant women and fetuses. The objective of this study was to investigate the impact of behenic acid (BA) on glucose metabolism, inflammation, and insulin resistance in GDM mice, and to elucidate the underlying molecular mechanism. Here, we demonstrated that daily administration of 10 mg/mL BA during pregnancy effectively ameliorated abnormal glucose metabolism in GDM mice and their offspring and improved birth outcomes in the offspring. Moreover, BA promoted the proliferation of islet β cells, restored their normal function, and augmented glucose uptake by skeletal muscle cells. Mechanistically, BA mitigated inflammation and insulin resistance in GDM mice by inhibiting activation of the TLR4/NF-κB signaling pathway. Our study provides compelling evidence supporting the efficacy of BA in improving GDM, suggesting its potential use as a dietary supplement for preventing and treating GDM.

2024-10-01·International Journal of Biological Macromolecules

Flexible, breathable, and durable superhydrophobic cotton fabric modified by behenic acid, tung oil, and ZIF-8 with anti-icing and self-cleaning properties

Article

作者: Xing, Tieling ; Yuan, Hua-Bin ; Wang, Jiapeng ; Zhao, Manman ; Chen, Zhong ; Chen, Guoqiang

Textiles with self-cleaning and anti-icing capabilities in cold climates are essential for outdoor workers and enthusiasts. Superhydrophobic modification of textile surfaces is effective in imparting these characteristics. Although there are numerous methods available for manufacturing superhydrophobic textiles, careful consideration is warranted for environmental concerns over fluorochemicals, stability of superhydrophobic coatings, and fabric breathability. In this work, we utilized biomass resources such as tung oil and behenic acid, along with zeolitic imidazolate framework (ZIF-8), to modify cotton fabrics, thereby creating an innovative behenic acid/tung oil/ZIF-8 modified cotton (BTZC) fabric with anti-icing and self-cleaning features. This material manifests a unique nanoflower-shaped surface morphology, demonstrating exceptional superhydrophobicity with a static water contact angle (CA) of 162° and a sliding angle (SA) of 2°. Moreover, BTZC excels in its thermal stability, breathability, and resistance to icing. Equally impressive is its robust stability, as evidenced through rigorous testing under continuous washing and abrasion, sustained high and low temperatures, extreme pH environments, and immersion in various chemical solvents. BTZC presents as a fluorine-free, durable, economically viable alternative for outdoor textile applications, marking substantial progress in the utilization of biomass and metal-organic framework materials in the textile industry and promising implications for value enhancement.

2024-09-01·The Journal of nutrition, health and aging

Discovering the direct relations between nutrients and epigenetic ageing

Article

作者: Horvath, Steve ; de Groot, Lisette ; Behrouzi, Pariya ; Yang, Bo ; Liu, Simin ; Biemans, Ynte ; Bach, Daimy ; Manson, JoAnn E ; Kramer, Charlotte S ; Whitsel, Eric ; Grootswagers, Pol ; Stewart, James D ; Shadyab, Aladdin H

BACKGROUNDAlong with the ageing of society, the absolute prevalence of age-related diseases is expected to rise, leading to a substantial burden on healthcare systems and society. Thus, there is an urgent need to promote healthy ageing. As opposed to chronological age, biological age was introduced to accurately represent the ageing process, as it considers physiological deterioration that is linked to morbidity and mortality risk. Furthermore, biological age responds to various factors, including nutritional factors, which have the potential to mitigate the risk of age-related diseases. As a result, a promising biomarker of biological age known as the epigenetic clock has emerged as a suitable measure to investigate the direct relations between nutritional factors and ageing, thereby identifying potential intervention targets to improve healthy ageing.METHODSIn this study, we analysed data from 3,969 postmenopausal women from the Women's Health Initiative to identify nutrients that are associated with the rate of ageing by using an accurate measure of biological age called the PhenoAge epigenetic clock. We used Copula Graphical Models, a data-driven exploratory analysis tool, to identify direct relationships between nutrient intake and age-acceleration, while correcting for every variable in the dataset.RESULTSWe revealed that increased dietary intakes of coumestrol, beta-carotene and arachidic acid were associated with decelerated epigenetic ageing. In contrast, increased intakes of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A and ash were associated with accelerated epigenetic ageing in postmenopausal women.CONCLUSIONOur study discovered direct relations between nutrients and epigenetic ageing, revealing promising areas for follow-up studies to determine the magnitude and causality of our estimated diet-epigenetic relationships.

100 项与二十二醇相关的药物交易

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