The Safety, Efficacy and Convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.

Recurrent cold sores - herpes simplex labialis (HSL) occurs in 20-40% of the US population and patient seek treatment because of the discomfort and visibility of the lesion although it is a self limiting disease. The purpose of this study is to check the safety, Efficacy and convenience of Use of the Natural Agent "Superlysin Gel" as Treatment for Herpes Labialis in Comparison to Acyclovir 5% and Docozanole 10%.

开始日期-

申办/合作机构

Hadassah University Hospital

100 项与二十二醇相关的临床结果

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100 项与二十二醇相关的转化医学

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100 项与二十二醇相关的专利（医药）

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1,263

项与二十二醇相关的文献（医药）

2025-09-01·INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Topical and Systemic Therapeutic Approaches in the Treatment of Oral Herpes Simplex Virus Infection: A Systematic Review.

Review

作者: Trilli, Irma ; Dipalma, Gianna ; Inchingolo, Francesco ; Mancini, Antonio ; Sardano, Roberta ; Pezzolla, Carmela ; Palermo, Andrea ; Marinelli, Grazia ; Inchingolo, Angelo Michele ; Inchingolo, Alessio Danilo

Herpes Simplex Virus (HSV) infections, caused primarily by HSV-1 and HSV-2, are among the most prevalent viral diseases worldwide, with recurrent manifestations that significantly affect quality of life. Therapeutic strategies include both topical and systemic interventions, each with distinct goals. This systematic review was conducted according to PRISMA guidelines. A comprehensive search of PubMed, Scopus, and Web of Science (2005-2025) identified studies evaluating topical or systemic treatments for HSV. Eligible studies included randomized controlled trials and observational studies reporting validated clinical outcomes. Topical treatments, including acyclovir cream, docosanol, and newer formulations, primarily reduce lesion duration and alleviate local symptoms when applied early. These interventions have limited systemic absorption and generally do not influence recurrence frequency. Novel delivery methods and combination strategies, such as acyclovir-hydrocortisone formulations or photodynamic therapy, may enhance local efficacy and symptom control. Systemic Therapies: Systemic antivirals, such as acyclovir, valacyclovir, and famciclovir, target both lesion resolution and recurrence prevention. Evidence from randomized trials supports their use for episodic and suppressive therapy, including short-course, high-dose regimens that improve adherence while controlling symptoms. Systemic therapy is particularly indicated for recurrent, disseminated, or high-risk infections. Topical and systemic therapies serve complementary roles in HSV management. Topical agents are useful for localized or initial episodes, while systemic therapy addresses broader clinical objectives, including recurrence reduction. Future research should focus on mechanism-based therapies, novel delivery systems, and standardized outcome measures to guide personalized treatment strategies. Emerging therapies targeting viral latency, immune modulation, and gene-editing technologies hold promise for long-term suppression and personalized management of HSV infections.

2025-08-01·BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Comparison of chemical composition, nematicidal activity and acetylcholinesterase inhibition with in silico mechanistic insights of Hedychium flavescens essential oils and extracts from aerial parts and rhizomes

作者: Prakash, Om ; Kumar, Satya ; Isidorov, Valery A. ; Bargali, Pooja ; Garzoli, Stefania ; Karakoti, Himani ; Kumar, Ravendra ; Rawat, Dharmendra Singh ; Maslowiecka, Jolanta

Hedychium flavescens is recognized for its medicinal and pesticidal potential, yet its comprehensive phytochem. profile and bioactivity against nematodes remain underexplored.This study offers a comparative anal. of the chem. composition, nematicidal activity and acetylcholinesterase (AChE) inhibition of essential oils (EOs) and extracts from the plant′s aerial and rhizome parts.GC-MS anal. identified significant chem. variation between the parts, with monoterpenes and sesquiterpenes predominating in both EOs.The major compounds were α-pinene, β-pinene, 1,8-cineole, linalool, and E-caryophyllene.On the other side, the extracts were dominated by fatty acids, sterols, and diterpenoids.Nematicidal activity was evaluated against Meloidogyne incognita, with rhizome EO showing higher potency (76% mortality at 1 μL/mL).Aerial and rhizome EOs exhibited significant nematode egg hatching inhibition, with 77.59-89.66% inhibition at 1000 μg/mL after 96 h of exposure.In-vitro AChE inhibition assays demonstrated potential neuroprotective properties in terms of IC₅₀ values with rhizome EO showing best inhibition activity (IC₅₀ = 181.03 μg/mL).Addnl., in silico docking studies provided insights into the mechanism of action of key compounds on AChE.The findings support H. flavescens as a natural alternative to synthetic nematicides and AChE inhibitors.Further studies are needed to explore its broader applications.

2025-07-18·PETROLEUM SCIENCE AND TECHNOLOGY

Role of acrylate terpolymers in flow assurance studies of crude oil

作者: Nagar, Ashish ; Patel, Zarana ; Patel, Jinal

Paraffinic crude oil causes deposition in the pipeline at low temperatures which hinders the flow during pipeline transportation.The primary technique for mitigation of paraffin deposition is chem. treatment.Polymeric chem. additives have gained considerable attention as flow improvers for waxy crude oil. Terpolymer application for flow assurance is a novel approach since terpolymers are seldom used as chem. additives for crude oil.Current research aims to synthesize four acrylate terpolymers with different alkyl pendant chains and study their effect on the rheol. behavior of crude oil.The structure of additives was validated and their depression effect was investigated.The results of the investigation revealed that the additives showed significant decrease in pour point (DPP _1/4 21 C for CO-1 and 15 C for CO-2) at a dose of 1000 ppm for CO-1 and 2000 ppm for CO-2.These results were also supported by rheol. data which exhibited a significant reduction in viscosity (>75%) of both the crude oils which showed the efficiency of additives as flow improvers.Moreover, the cold finger test displayed excellent paraffin inhibition efficiency of synthesized additives (66 and 52% for CO-1 and CO-2, resp.). The investigation demonstrated a promising role of terpolymers as flow improvers for waxy crude oil.

100 项与二十二醇相关的药物交易

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