预约演示
更新于：2025-07-05
Apocyanin
香草乙酮
更新于：2025-07-05
概要
基本信息
结构/序列
分子式C9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS号498-02-2 |
关联
7
项与 香草乙酮 相关的临床试验CTIS2023-508791-11-00
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
IRCT20200418047122N1
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
NCT03680404
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
100 项与 香草乙酮 相关的临床结果
登录后查看更多信息
100 项与 香草乙酮 相关的转化医学
登录后查看更多信息
100 项与 香草乙酮 相关的专利（医药）
登录后查看更多信息
6,997
项与 香草乙酮 相关的文献（医药）2025-10-01FUEL
Sustainable marine fuel production through mild hydrotreating of catalytic fast pyrolysis bio-oil
作者: Tan, Eric C. D. ; Mukarakate, Calvin ; Chen, Xiaolin ; Orton, Kellene A. ; Arellano-Trevino, Martha A. ; Dutta, Abhijit ; Iisa, Kristiina
Lignocellulosic biomass-derived biofuels have great potential to reduce sulfur and fossil carbon dioxide emissions from the maritime sector and help achieve the International Maritime Organization (IMO) targets and, at the same time, meet the increasing demand for low-carbon marine fuels.In this work, woody biomass-derived catalytic fast pyrolysis (CFP) oil was evaluated as an alternative to fossil marine fuels.CFP oil is not fully fungible with conventional marine fuels and needs to be further upgraded.The heavy organic fraction (bottom layer) of CFP oil, which constitutes 90 % of CFP oil, was hydrotreated at 300-350 °C, 103 bar (1500 psi) with weight hourly space velocities (WHSV) of 0.12-0.24 g/(gh).The aim was to produce a biofuel that meets key marine fuel properties required by ISO 8217 and is miscible with very-low-sulfur fuel oil (VLSFO).The bottom CFP oil with 23 wt% oxygen (dry basis) became significantly deoxygenated and contained < 0.01-5 % wt% oxygen at all hydrotreating conditions studied.Decreasing the hydrotreating temperature or increasing the WHSV reduced deoxygenation and hydrogenation.The hydrotreated oils were distilled at 140 °C to remove water and low-boiling compounds to increase the flash point for marine fuel cuts.The products after distillation were miscible with VLSFO and met all tested ISO 8217 specifications except for the product from the least severe condition having a slightly higher d. (1020 vs. < 1010 kg/m3).A comparative techno-economic anal. with conceptual scale-up of the four exptl. cases showed that lower hydrotreating severity with higher space velocities, allowing the retention of more oxygen in the fuel, can reduce hydrotreating costs by up to 30 % within the 0.12-0.24 g/(gh) WHSV range.Cost benefits were achieved by using smaller reactor and catalyst volumes, resulting in up to 1/3 less hydrogen consumption.Higher oxygen retention and less hydrogenation of the fuel also contribute to heavier mols. with lower fuel volatility (and higher flash points) and can thus generally allow larger proportions of the hydrotreated products to be suitable for use as marine fuel.
2025-09-01SEPARATION AND PURIFICATION TECHNOLOGY
Ni-substituted POM@UIO-66 catalyst for high-efficiency catalytic conversion of larch lignin
作者: Zhang, Dan ; Shi, Junyou ; Liu, Yuting ; Xu, Wenbiao ; Deng, Haoyu ; Li, Xiangyu
Converting abundant lignin resources into high-value chems. has always been a pivotal approach in biomass refining.Among various methods, catalytic oxidative depolymerization stands out as one of the most promising approaches due to its mild reaction conditions and remarkable efficiency.In this study, we present a series of transition metal-substituted Ni/Co-PMo/PW@UIO-66 catalysts, among which NiPMo@UIO-66 demonstrated the superior catalytic performance after thorough characterization.Through more in-depth research, it was found that under the optimal reaction conditions of 160 °C, 1.0 MPa O2, and 3 h, the strong Bronsted acidity inherent in POM, combined with the excellent redox properties, the moderate Lewis acidity provided by Ni and Zr, and the improved substrate-catalyst interfacial contact offered by the UIO-66 carrier, synergistically yielded the formation of the high amount of primary products and outstanding selectivity (>90 %).Therefore, the optimal yields of vanillin and Me vanillate reached 11.26 wt%.In terms of stability, the POM undergoes partial decomposition after multiple uses, while the UIO-66 framework maintains remarkable stability.This study aims to provide insightful and inspiring contributions to the design of catalysts within the lignin catalytic oxidative valorization system.
2025-09-01TOXICOLOGY AND APPLIED PHARMACOLOGY
Integrating phosphoproteome and proteome to reveal key processes through which apocynin protects from lethal ventricular arrhythmias-sudden cardiac death in early myocardial ischemia
Article
作者: Lai, Minchao ; Wang, Dian ; Liang, Huishan ; Xiao, Xudong ; Zhang, Wei ; Lv, Junyao ; Zhang, Ye ; Zhou, Danya ; Yu, Xiaojun ; Zhang, Xiaojun ; Zhu, Guanghui ; Zhang, Mengxuan
The specific role of NADPH oxidases (NOX)-dependent reactive oxygen species (X-ROS) in the development of lethal ventricular arrhythmias (LVA)-sudden cardiac death (SCD) during the early stage of myocardial ischemia (MI) remains poorly understood. Herein, we investigated the impact of X-ROS on LVA-SCD in early MI. The mouse model of MI-induced LVA-SCD and the apocynin (a NOX inhibitor)-pretreated control groups were established. Survival and the electrophysiological parameters were analyzed, and mitochondrial membrane potential (MMP), superoxide dismutase (SOD) activity, ratio of reduced and oxidized glutathione (GSH/GSSG), and ROS and Ca2+ levels were assessed. Additionally, cardiac phosphoproteome and proteome analyses were conducted to explore the phosphorylation-related mechanisms by which apocynin protects against LVA-SCD. Our findings revealed that apocynin reduced the incidence of LVA-SCD in early MI and corrected the ECG alterations associated with LVA. Apocynin also mitigated elevated levels of ROS and Ca2+ both in mitochondria and cytosol, and decreased GSH/GSSG ratio, SOD activity, and MMP in SCD. After adjusting for proteome data, 548 proteins showed significant changes in their phosphorylation levels in SCD mice. The up-regulated phosphorylated proteins normalized by apocynin were mainly linked to the tricarboxylic acid cycle (TCA), electron transport chain (ETC) function, and calcium signal pathways. The down-regulated phosphorylated proteins normalized by apocynin were mainly relevant to arrhythmogenic right ventricular cardiomyopathy and AMPK signaling pathway. Collectively, our data suggest that X-ROS promotes LVA-SCD in early MI, with Ca2+ imbalance and mitochondrial dysfunction, primarily mediated by phosphorylation changes in mitochondrial proteins, playing a crucial role.
100 项与 香草乙酮 相关的药物交易
登录后查看更多信息
研发状态
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性阻塞性肺疾病 | 临床1期 | - | 2010-10-01 | |
| 哮喘 | 临床1期 | 波兰 | 2008-06-01 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | - | - | 繭餘餘醖製顧鑰繭齋築(鬱壓膚夢顧衊廠齋願鏇) = 夢觸衊襯鹽襯鏇鬱積簾 醖廠積醖餘願齋鏇顧衊 (範範鹽鏇淵觸鹹構網膚 ) | 积极 | 2024-06-05 | ||
淵願鹽遞築築糧願鏇觸(衊衊壓齋壓製鹽構積齋) = 鹽選築鹽顧憲醖憲窪觸 窪鹹壓壓簾簾選製艱衊 (選鏇艱積淵壓網廠艱廠 ) 更多 | |||||||
N/A | - | Apocynin and paeonol (APPA) | 淵遞築糧廠範製觸顧齋(齋簾遞簾繭夢遞齋餘壓) = 襯鬱醖夢獵築選鏇繭築 簾範簾蓋膚醖窪構範艱 (簾夢膚壓選憲餘膚壓鏇 ) | 积极 | 2020-06-03 | ||
N/A | - | - | AN-1 | 構鹹積範鬱餘壓憲壓願(鹽網簾簾齋壓繭糧繭艱) = 鬱繭積遞鑰築襯鏇膚範 範積製鏇夢範糧憲窪築 (構廠獵艱網餘選憲積壓 ) 更多 | - | 2013-07-30 | |
構鹹積範鬱餘壓憲壓願(鹽網簾簾齋壓繭糧繭艱) = 鑰觸襯願壓網齋艱廠積 範積製鏇夢範糧憲窪築 (構廠獵艱網餘選憲積壓 ) 更多 | |||||||
N/A | 高血压 reactive oxygen species (ROS) | - | 窪襯艱鏇鏇鑰蓋築願餘(繭夢構簾遞襯夢廠積願) = 積鏇願夢糧網鹹選獵壓 顧鏇選衊艱鹹網窪觸顧 (鑰願齋衊構廠網鏇鬱鏇 ) 更多 | 积极 | 2012-09-01 | ||
窪襯艱鏇鏇鑰蓋築願餘(繭夢構簾遞襯夢廠積願) = 鏇餘醖衊醖遞蓋鹽衊觸 顧鏇選衊艱鹹網窪觸顧 (鑰願齋衊構廠網鏇鬱鏇 ) | |||||||
N/A | - | - | 範鏇衊顧範顧獵鏇遞襯(糧鏇鬱網鹽壓顧窪獵醖) = 願鏇願壓遞廠鹽遞築鏇 範廠夢齋遞鏇鹽淵構壓 (構窪積鑰夢壓襯鹽廠遞 ) 更多 | - | 2011-09-01 | ||
N/A | 14 | 選蓋鏇觸襯鑰夢觸構鑰(夢憲獵鹹構積遞壓憲醖) = 鹽糧餘觸網齋簾願膚糧 窪齋範鑰衊願構獵齋餘 (選鏇廠遞艱鏇築窪簾齋 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 選蓋鏇觸襯鑰夢觸構鑰(夢憲獵鹹構積遞壓憲醖) = 鬱膚醖餘範窪觸窪築廠 窪齋範鑰衊願構獵齋餘 (選鏇廠遞艱鏇築窪簾齋 ) 更多 | ||||||
N/A | - | - | 鬱獵繭鹽遞鹽齋淵糧夢(衊鏇鹹積鑰獵顧艱獵鑰) = 衊鏇鬱廠餘膚鹹願糧鏇 鬱艱憲遞構蓋製範衊艱 (廠齋鑰夢願醖築廠夢衊 ) 更多 | - | 2011-09-01 | ||
Placebo | 鬱獵繭鹽遞鹽齋淵糧夢(衊鏇鹹積鑰獵顧艱獵鑰) = 鬱鑰窪選窪構構築膚蓋 鬱艱憲遞構蓋製範衊艱 (廠齋鑰夢願醖築廠夢衊 ) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用