预约演示
更新于：2025-07-12
Apocyanin
香草乙酮
更新于：2025-07-12
概要
基本信息
结构/序列
分子式C9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS号498-02-2 |
关联
7
项与 香草乙酮 相关的临床试验CTIS2023-508791-11-00
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
IRCT20200418047122N1
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
NCT03680404
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
100 项与 香草乙酮 相关的临床结果
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100 项与 香草乙酮 相关的转化医学
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100 项与 香草乙酮 相关的专利（医药）
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7,001
项与 香草乙酮 相关的文献（医药）2025-10-01FUEL
Sustainable marine fuel production through mild hydrotreating of catalytic fast pyrolysis bio-oil
作者: Tan, Eric C. D. ; Mukarakate, Calvin ; Chen, Xiaolin ; Orton, Kellene A. ; Arellano-Trevino, Martha A. ; Dutta, Abhijit ; Iisa, Kristiina
Lignocellulosic biomass-derived biofuels have great potential to reduce sulfur and fossil carbon dioxide emissions from the maritime sector and help achieve the International Maritime Organization (IMO) targets and, at the same time, meet the increasing demand for low-carbon marine fuels.In this work, woody biomass-derived catalytic fast pyrolysis (CFP) oil was evaluated as an alternative to fossil marine fuels.CFP oil is not fully fungible with conventional marine fuels and needs to be further upgraded.The heavy organic fraction (bottom layer) of CFP oil, which constitutes 90 % of CFP oil, was hydrotreated at 300-350 °C, 103 bar (1500 psi) with weight hourly space velocities (WHSV) of 0.12-0.24 g/(gh).The aim was to produce a biofuel that meets key marine fuel properties required by ISO 8217 and is miscible with very-low-sulfur fuel oil (VLSFO).The bottom CFP oil with 23 wt% oxygen (dry basis) became significantly deoxygenated and contained < 0.01-5 % wt% oxygen at all hydrotreating conditions studied.Decreasing the hydrotreating temperature or increasing the WHSV reduced deoxygenation and hydrogenation.The hydrotreated oils were distilled at 140 °C to remove water and low-boiling compounds to increase the flash point for marine fuel cuts.The products after distillation were miscible with VLSFO and met all tested ISO 8217 specifications except for the product from the least severe condition having a slightly higher d. (1020 vs. < 1010 kg/m3).A comparative techno-economic anal. with conceptual scale-up of the four exptl. cases showed that lower hydrotreating severity with higher space velocities, allowing the retention of more oxygen in the fuel, can reduce hydrotreating costs by up to 30 % within the 0.12-0.24 g/(gh) WHSV range.Cost benefits were achieved by using smaller reactor and catalyst volumes, resulting in up to 1/3 less hydrogen consumption.Higher oxygen retention and less hydrogenation of the fuel also contribute to heavier mols. with lower fuel volatility (and higher flash points) and can thus generally allow larger proportions of the hydrotreated products to be suitable for use as marine fuel.
2025-09-01INTERNATIONAL IMMUNOPHARMACOLOGY
NOX2-mediated reactive oxygen species contribute to angiotensin II-induced cardiac hypertrophy by promoting cardiomyocyte autophagy via Atg4B S-glutathionylation modification
Article
作者: Cui, Xuelin ; Zhao, Yanfang ; Lv, Mengzhu ; Yang, Bing ; Cai, Yan ; He, Juan ; Cao, Huili ; Chai, Chanjuan ; Shi, Fang ; Chi, Ruifang
The NADPH oxidase (NOX) 2-dependent reactive oxygen species (ROS) mediate cell autophagy to participate in a variety of cardiovascular diseases. However, whether NOX2-mediated ROS facilitates angiotensin II-induced cardiac hypertrophy by promoting cardiomyocyte autophagy is still unknown. Mouse cardiomyocytes were stimulated with angiotensin II for different time in the presence and absence of apocynin or 3-methyladenine. Angiotensin II-induced NOX2-knockdown cardiomyocytes and NOX2-deficient mice were used to explore the function of NOX2 in angiotensin II-induced cardiomyocyte hypertrophy, oxidative stress (OxS), and autophagy. The abundance of several proteins was detected by western blot. Wheat germ agglutinin and Masson's staining determined cardiomyocyte size and cardiac fibrosis. OxS was determined by analyzing ROS production, malondialdehyde levels, and superoxide dismutase activity. Co-immunoprecipitation was performed to explore the S-glutathionylation of autophagy-related gene 4B (Atg4B). Apocynin and 3-methyladenine treatment decreased angiotensin II-mediated elevation in atrial natriuretic peptide and LC3 II/LC3 I protein levels but not NOX2. NOX2 silencing impaired angiotensin II-induced cell hypertrophy, ROS production, and autophagy in cardiomyocytes. Consistently, NOX2-deficient mice exhibited improvements in cardiac dysregulation, hypertrophy, and fibrosis, coupled with reduced OxS and autophagy. NOX2 silencing decreased angiotensin II-induced upregulation of Atg4B. Moreover, Atg4B knockdown improved angiotensin II-induced cardiomyocyte hypertrophy and autophagy, whereas NOX2 overexpression did not work in Atg4B knockdown-cardiomyocytes. Mechanistically, angiotensin II-induced NOX2 facilitates the S-glutathionylation of Atg4B. NOX2-dependent ROS facilitates angiotensin II-induced cardiac hypertrophy via Atg4B S-glutathionylation modification, indicating that targeting the S-glutathionylation of Atg4B may be a potential adjunct therapeutic strategy for cardiac hypertrophy, complementary to existing standard treatments.
2025-09-01SEPARATION AND PURIFICATION TECHNOLOGY
Ni-substituted POM@UIO-66 catalyst for high-efficiency catalytic conversion of larch lignin
作者: Zhang, Dan ; Shi, Junyou ; Liu, Yuting ; Xu, Wenbiao ; Deng, Haoyu ; Li, Xiangyu
Converting abundant lignin resources into high-value chems. has always been a pivotal approach in biomass refining.Among various methods, catalytic oxidative depolymerization stands out as one of the most promising approaches due to its mild reaction conditions and remarkable efficiency.In this study, we present a series of transition metal-substituted Ni/Co-PMo/PW@UIO-66 catalysts, among which NiPMo@UIO-66 demonstrated the superior catalytic performance after thorough characterization.Through more in-depth research, it was found that under the optimal reaction conditions of 160 °C, 1.0 MPa O2, and 3 h, the strong Bronsted acidity inherent in POM, combined with the excellent redox properties, the moderate Lewis acidity provided by Ni and Zr, and the improved substrate-catalyst interfacial contact offered by the UIO-66 carrier, synergistically yielded the formation of the high amount of primary products and outstanding selectivity (>90 %).Therefore, the optimal yields of vanillin and Me vanillate reached 11.26 wt%.In terms of stability, the POM undergoes partial decomposition after multiple uses, while the UIO-66 framework maintains remarkable stability.This study aims to provide insightful and inspiring contributions to the design of catalysts within the lignin catalytic oxidative valorization system.
100 项与 香草乙酮 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性阻塞性肺疾病 | 临床1期 | - | 2010-10-01 | |
| 哮喘 | 临床1期 | 波兰 | 2008-06-01 |
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临床结果
临床结果
适应症
分期
评价
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N/A | - | - | 憲製夢網艱夢鹹鹹淵顧(壓範築襯壓壓餘鹹觸夢) = 範齋鏇糧鬱夢衊製簾簾 鏇艱鏇淵蓋糧鹹鹹範淵 (膚製鏇觸膚築選繭餘願 ) | 积极 | 2024-06-05 | ||
憲簾憲艱顧繭選窪憲獵(鬱願選鑰餘遞製觸構遞) = 膚襯憲衊顧簾獵糧廠鹹 憲簾製窪遞膚製範選鑰 (壓壓廠觸壓蓋觸構選艱 ) 更多 | |||||||
N/A | - | Apocynin and paeonol (APPA) | 鑰夢構鬱窪網鹽獵構蓋(餘膚繭醖顧窪衊憲願鹹) = 繭構夢遞壓觸築簾選範 鑰願齋衊糧觸簾壓衊製 (構憲簾壓網夢夢積鹹鑰 ) | 积极 | 2020-06-03 | ||
N/A | - | - | AN-1 | 鬱鏇築願鑰顧獵製簾壓(鬱鹹衊鹽壓網醖製醖憲) = 積醖觸艱範鑰網憲艱餘 願壓壓壓膚膚構夢範壓 (範繭廠鑰窪遞獵鏇簾繭 ) 更多 | - | 2013-07-30 | |
鬱鏇築願鑰顧獵製簾壓(鬱鹹衊鹽壓網醖製醖憲) = 鑰淵膚齋鑰艱衊醖鹹醖 願壓壓壓膚膚構夢範壓 (範繭廠鑰窪遞獵鏇簾繭 ) 更多 | |||||||
N/A | 高血压 reactive oxygen species (ROS) | - | 壓淵觸簾繭鹹艱選醖願(鏇鏇淵衊鹹衊遞觸鹽齋) = 衊夢鹹襯築淵獵築夢餘 鹹築膚醖膚願簾願製鏇 (獵簾鬱餘網觸繭衊遞蓋 ) 更多 | 积极 | 2012-09-01 | ||
壓淵觸簾繭鹹艱選醖願(鏇鏇淵衊鹹衊遞觸鹽齋) = 憲築遞餘壓繭遞窪鹹憲 鹹築膚醖膚願簾願製鏇 (獵簾鬱餘網觸繭衊遞蓋 ) | |||||||
N/A | - | - | 網鬱糧衊選鏇繭觸鏇鑰(鹽獵襯遞淵鏇壓壓膚築) = 繭餘鬱齋遞繭選範顧築 簾鑰顧顧淵醖齋築夢構 (顧衊衊淵廠遞壓窪糧齋 ) 更多 | - | 2011-09-01 | ||
N/A | 14 | 鏇齋齋選蓋鏇淵鬱簾獵(觸獵窪蓋壓願範蓋構鏇) = 鏇廠構糧淵鏇獵遞壓範 積顧襯簾網艱壓淵襯憲 (鏇觸選窪憲簾鏇餘構淵 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 鏇齋齋選蓋鏇淵鬱簾獵(觸獵窪蓋壓願範蓋構鏇) = 糧襯鹹獵構鑰壓獵衊襯 積顧襯簾網艱壓淵襯憲 (鏇觸選窪憲簾鏇餘構淵 ) 更多 | ||||||
N/A | - | - | 醖製蓋鑰憲繭醖壓願壓(築夢築廠膚窪願範網鹽) = 鹹網醖遞膚鏇選膚餘餘 艱選鑰遞廠壓繭網廠鹽 (糧壓餘襯餘艱鏇艱醖製 ) 更多 | - | 2011-09-01 | ||
Placebo | 醖製蓋鑰憲繭醖壓願壓(築夢築廠膚窪願範網鹽) = 醖願願廠壓觸積淵觸鬱 艱選鑰遞廠壓繭網廠鹽 (糧壓餘襯餘艱鏇艱醖製 ) 更多 |
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