更新于：2024-07-20
Apocyanin
香草乙酮
更新于：2024-07-20
概要
基本信息
结构
分子式C9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS号498-02-2 |
关联
7
项与 香草乙酮 相关的临床试验A placebo-controlled, double-blinded, randomized, trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
The Effect of Local Antioxidant Therapy on Racial Differences in Vasoconstriction
100 项与 香草乙酮 相关的临床结果
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100 项与 香草乙酮 相关的转化医学
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100 项与 香草乙酮 相关的专利（医药）
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2,327
项与 香草乙酮 相关的文献（医药）2024-02-07Clinical science (London, England : 1979)
Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4/H2O2/PPAR-γ axis
Article
作者: Li, Shaohua ; Shi, Qixin ; Lyu, Qiang ; Bai, Yungang ; Ma, Jin ; Ren, Xinling
Abstract:
High-altitude pulmonary hypertension (HAPH) is a severe and progressive disease that can lead to right heart failure. Intermittent short-duration reoxygenation at high altitude is effective in alleviating HAPH; however, the underlying mechanisms are unclear. In the present study, a simulated 5,000-m hypoxia rat model and hypoxic cultured pulmonary artery smooth muscle cells (PASMCs) were used to evaluate the effect and mechanisms of intermittent short-duration reoxygenation. The results showed that intermittent 3-h/per day reoxygenation (I3) effectively attenuated chronic hypoxia-induced pulmonary hypertension and reduced the content of H2O2 and the expression of NADPH oxidase 4 (NOX4) in lung tissues. In combination with I3, while the NOX inhibitor apocynin did not further alleviate HAPH, the mitochondrial antioxidant MitoQ did. Furthermore, in PASMCs, I3 attenuated hypoxia-induced PASMCs proliferation and reversed the activated HIF-1α/NOX4/PPAR-γ axis under hypoxia. Targeting this axis offset the protective effect of I3 on hypoxia-induced PASMCs proliferation. The present study is novel in revealing a new mechanism for preventing HAPH and provides insights into the optimization of intermittent short-duration reoxygenation.
2024-02-01Inflammation
Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid–Induced Colitis in Rats
Article
作者: Ferjani, Wafa ; Ghanem-Boughanmi, Néziha ; Dang, Pham My-Chan ; Ben-Attia, Mossadok ; Kouki, Ahmed ; Souli, Abdelaziz ; El-Benna, Jamel
Ulcerative colitis is an inflammatory bowel disease with a complex aetiology characterised by abnormal immune responses and oxidative stress-induced tissue injury. Inflammatory cells play an important role in the progression of this pathology through the overproduction of reactive oxygen species (ROS) from various sources including the NADPH oxidases (NOXs). The aim of this study was to investigate the preventive effect of apocynin, a natural antioxidant molecule and a selective inhibitor of NOXs, on acetic acid (AA)-induced ulcerative colitis in rats. Our results first confirmed that apocynin has a high free radical scavenging capacity as well as a potent iron chelating ability. Oral pretreatment of rats with apocynin (200 mg/kg and 400 mg/kg) for 7 days prior to AA-induced colitis suppressed the increase in pro-oxidant markers in colonic homogenates and preserved colonic cytoarchitecture from acetic acid-induced damage. Oral administration of apocynin (200 mg/kg and 400 mg/kg) also reduced several systemic inflammatory markers such as alkaline phosphatase, iron, pro-inflammatory cytokines, C-reactive protein and myeloperoxidase. This study shows that apocynin protects rats from acetic acid-induced colonic inflammation and suggests that apocynin may have a promising beneficial effect in the prevention of ulcerative colitis.
2024-02-01Alzheimer's & dementia : the journal of the Alzheimer's Association
Angiotensin II‐mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats
Article
作者: Scoppettone, Nadia ; McGinn, Conor ; Tremble, Sarah M ; Hunt, Ryan D ; Guth, Ruby ; Prakash, Kirtika ; Johnson, Abbie C ; Gannon, Olivia
Abstract:
INTRODUCTION:
Chronic hypertension increases the risk of vascular cognitive impairment (VCI) by ∼60%; however, how hypertension affects the vasculature of the hippocampus remains unclear but could contribute to VCI.
METHODS:
Memory, hippocampal perfusion, and hippocampal arteriole (HA) function were investigated in male Wistar rats or spontaneously hypertensive rats (SHR) in early (4 to 5 months old), mid (8 to 9 months old), or late adulthood (14 to 15 months old). SHR in late adulthood were chronically treated with captopril (angiotensin converting enzyme inhibitor) or apocynin (antioxidant) to investigate the mechanisms by which hypertension contributes to VCI.
RESULTS:
Impaired memory in SHR in late adulthood was associated with HA endothelial dysfunction, hyperconstriction, and ∼50% reduction in hippocampal blood flow. Captopril, but not apocynin, improved HA function, restored perfusion, and rescued memory function in aged SHR.
DISCUSSION:
Hippocampal vascular dysfunction contributes to hypertension‐induced memory decline through angiotensin II signaling, highlighting the therapeutic potential of HAs in protecting neurocognitive health later in life.
Highlights:
Vascular dysfunction in the hippocampus contributes to vascular cognitive impairment.Memory declines with age during chronic hypertension.Angiotensin II causes endothelial dysfunction in the hippocampus in hypertension.Angiotensin II‐mediated hippocampal arteriole dysfunction reduces blood flow.Vascular dysfunction in the hippocampus impairs perfusion and memory function.
100 项与 香草乙酮 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 动脉粥样硬化 | 临床1期 | - | - | - |
| 糖尿病性神经病变 | 临床1期 | - | - | - |
| 高血压 | 临床1期 | - | - | - |
| 炎症性肠病 | 临床1期 | - | - | - |
| 帕金森病 | 临床1期 | - | - | - |
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临床结果
临床结果
适应症
分期
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N/A | - | - | 淵製壓窪顧壓淵鏇醖鏇(憲壓鹹艱簾簾鹹夢齋構) = 選齋選簾膚構遞築鬱繭 衊觸獵窪觸網糧觸壓窪 (鏇鑰淵餘簾築獵餘膚觸 ) 更多 | - | 2021-06-02 | ||
N/A | - | Apocynin and paeonol (APPA) | 蓋選顧淵鑰夢淵窪襯窪(鑰醖鏇衊蓋淵繭醖齋願) = 衊窪網齋選鑰襯積餘淵 襯餘蓋廠獵衊構繭蓋艱 (遞簾壓醖繭齋觸齋繭鏇 ) | 积极 | 2020-06-03 | ||
N/A | - | - | 構鑰顧鏇壓繭膚蓋膚蓋(夢夢積遞構蓋遞顧醖淵) = 鏇鹹鏇製築築廠壓範顧 壓蓋醖憲範簾積選廠壓 (齋範鏇觸膚蓋膚築鹽範 ) 更多 | - | 2011-09-01 | ||
N/A | 14 | 積衊簾選蓋醖製艱憲鑰(艱繭蓋繭膚簾鹹鑰鹹襯) = 積顧齋願襯鹹鏇襯糧艱 選繭製繭淵遞齋艱繭鏇 (繭顧選襯糧廠艱艱網淵 ) 更多 | 积极 | 2011-09-01 | |||
Placebo | 積衊簾選蓋醖製艱憲鑰(艱繭蓋繭膚簾鹹鑰鹹襯) = 醖廠憲衊鹽網襯網廠鑰 選繭製繭淵遞齋艱繭鏇 (繭顧選襯糧廠艱艱網淵 ) 更多 | ||||||
N/A | - | - | 衊壓壓壓築觸襯膚艱艱(構窪艱繭壓獵願願壓構) = 簾廠網艱鬱膚夢糧鹹顧 鹽繭鏇鬱糧壓壓遞鏇夢 (範壓餘壓網齋構顧積鹽 ) 更多 | - | 2011-09-01 | ||
Placebo | 衊壓壓壓築觸襯膚艱艱(構窪艱繭壓獵願願壓構) = 願襯獵蓋醖餘鹹窪餘壓 鹽繭鏇鬱糧壓壓遞鏇夢 (範壓餘壓網齋構顧積鹽 ) 更多 |
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