Stroke is a leading cause of mortality and disability in Mexico and worldwide. Although current treatment strategies focus on removing oclussion, they do not interrupt the signaling cascade of neuronal damage. Thus, the search for a cerebroprotective agent that can protect the entire brain. Melatonin has been proposed as a potential cerebroprotective agent due to its antioxidant, anti-inflammatory, antiapoptotic, and immunomodulatory effects, which oppose the pathophysiological mechanisms of cerebrovascular disease. Melatonin has the potential to improve stroke outcomes and reduce the risk of disability and mortality, making it a promising therapeutic option for stroke patients.
To assess the efficacy of melatonin in patients with acute ischemic CVD, improve clinical outcome, and infarct volume.

开始日期2024-03-01

申办/合作机构

Universidad Michoacana de San Nicolás de Hidalgo

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100 项与 Universidad Michoacana de San Nicolás de Hidalgo 相关的临床结果

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0 项与 Universidad Michoacana de San Nicolás de Hidalgo 相关的专利（医药）

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7,735

项与 Universidad Michoacana de San Nicolás de Hidalgo 相关的文献（医药）

2024-07-01·Journal of Molecular Structure

Corrigendum to “Synthesis, crystal structure, and intrinsic reactivity descriptors of coordination complexes of [(cis-PdCl2⋅L-proline) L-proline] and [trans-PdCl2⋅(glycine-OMe)]” [Journal of Molecular Structure, 1294 (2023), 136354]

作者: Avina-Verduzco, Judit A. ; Guzman-Mejia, Ramon ; Carlos Jimenez-Cruz, J. ; Garcia-Zavala, Stephanie ; Herrera-Bucio, Rafael ; Garcia-Gutierrez, Hugo A. ; Navarro-Santos, Pedro

2024-05-01·Journal of Plant Growth Regulation

CLE14 Peptide Impairs Root Tip Regeneration and Callogenesis in Arabidopsis

作者: Lopez-Bucio, Jose ; Gutierrez-Alanis, Dolores ; Avalos-Rangel, Adrian ; Ruiz-Herrera, Leon Francisco ; Raya-Gonzalez, Javier ; Herrera-Estrella, Luis

CLE14 belongs into a family of plant secreted peptides that interact with leucine-rich repeat receptor-like kinase (LRR-RLK) receptors to orchestrate plant morphogenesis.Previous studies indicated that CLE14 plays an important role in cell division, phosphate homeostasis, and senescence, but its specific involvement in cell fate determination and organogenesis remains largely unexplored.Here, through pharmacol., genetic, and cell biol. approaches, we show the critical roles for CLE14 in determining the balance between cell division and differentiation in root tip regeneration and callogenesis.Low concentrations of CLE14 or its overexpression in Arabidopsis repressed primary root growth while triggering lateral root and root hair formation.After resection of the primary root tip, CLE14 expression and accumulation were located specifically at the cell layer adjacent to the cutting and at the outermost external cell layer of the root cap as the newly root cap formed.The cle14 cr^-1 mutants or p35S: amirR-CLE14 lines with reduced levels of CLE14, had comparable root tip regeneration when compared to WT seedlings, whereas 35S: CLE14 seedlings failed to regenerate the missing root tip after resection.The de-differentiation of tissue into proliferative growth was analyzed in WT, cle14 cr^-1, and 35S: CLE14 stem explants grown in callus-inducing media.The results showed comparable callus biomass production for WT and cle14 cr^-1, but a dramatically reduced callogenesis for 35S: CLE14 explants.Thus, CLE14 acts to repress root tip regeneration as well as callogenesis in Arabidopsis.

2024-04-01·European Journal of Forest Research

Importance of abiotic factors in shaping canopy arthropod assemblages: the case of Quercus castanea Née (Fagales:Fagaceae) a Mexican endemic oak

作者: Oyama, Ken ; Loera-Padilla, Francisco Javier ; Maldonado-Lopez, Yurixhi ; Borges, Magno Augusto Zaza ; Vaca-Sanchez, Marcela Sofia ; Fernandes, G. Wilson ; de Faria, Mauricio Lopes ; Fagundes, Marcilio ; Lopez-Maldonado, Ma. Carmen ; Cuevas-Reyes, Pablo

The understanding of ecol. mechanisms shaping canopy arthropods community assembly, remains as one of the main targets of ecol.It is necessary to elucidate how abiotic factors such as precipitation shape arthropod communities in oak canopy.We evaluated the changes of canopy arthropod diversity assemblages associated to Quercus castanea along a precipitation gradient in four study sites, where Q. castanea occurs.Five mature Q. castanea trees were selected per site to collect canopy arthropods using fogging techniques.We collected 7,447 arthropods representing 754 morphospecies grouped into 16 different orders associated to Q. castanea along the precipitation gradient.We found differences in arthropod richness and abundance as well as in guild composition along the precipitation gradient.The general pattern showed higher canopy arthropod diversity in dry sites compared to wet sites.Also, arthropod guild composition differed along the precipitation gradient; dry sites harbored higher abundance of phytophages and detritivores, while wet sites had higher richness of phytophages and predators.Local climatic variables such as temperature were related to the canopy of Q. castanea arthropod community in dry sites.Our findings confirm that at a local scale, water availability is an important abiotic factor that generates changes in the assemblies of canopy arthropod community of Q. castanea, harboring more arthropod diversity in dry sites.We highlight the importance of conserving oak species because Mexico is the main center of richness, diversification and endemism of oaks in the northern hemisphere, and they represent key species in temperate forest harboring a great diversity of unique canopy arthropods.

100 项与 Universidad Michoacana de San Nicolás de Hidalgo 相关的药物交易

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100 项与 Universidad Michoacana de San Nicolás de Hidalgo 相关的转化医学

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