更新于：2024-11-21

Bendroflumethiazide/Potassium Chloride

苄氟噻嗪/氯化钾

更新于：2024-11-21

概要

概要

基本信息

药物类型

小分子化药

别名

Centyl K

靶点

NCC

作用机制

NCC抑制剂(噻嗪类敏感氯化钠协同转运蛋白抑制剂)

治疗领域

心血管疾病泌尿生殖系统疾病其他疾病

在研适应症

水肿高血压肾石病

非在研适应症-

原研机构

Karo Healthcare AB

在研机构

Karo Healthcare AB

非在研机构-

最高研发阶段批准上市

首次获批日期

瑞典 (2010-09-17),

水肿高血压肾石病

最高研发阶段(中国)-

特殊审评-

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结构

分子式ClK

InChIKeyWCUXLLCKKVVCTQ-UHFFFAOYSA-M

CAS号7447-40-7

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关联

项与苄氟噻嗪/氯化钾相关的临床试验

DRKS00004564 / RecruitingN/AIIT

Influence of Hippotherapy-K on adults with Cerebral Palsy on the functional parameters during walking and stair climbing - Hippo-K-CP

开始日期2012-12-12

申办/合作机构-

100 项与苄氟噻嗪/氯化钾相关的临床结果

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100 项与苄氟噻嗪/氯化钾相关的转化医学

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100 项与苄氟噻嗪/氯化钾相关的专利（医药）

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项与苄氟噻嗪/氯化钾相关的文献（医药）

1984-12-01·Calcified Tissue International3区 · 医学

The effect of bendroflumethiazide and hydrochlorothiazide on the rate of dissolution of calcium hydroxyapatite

3区 · 医学

Article

作者: Margaret R. Christoffersen ; Jørgen Christoffersen

Inhibition of dissolution of calcium hydroxyapatite in the presence of bendroflumethiazide, Centyl, and of hydrochlorothiazide has been investigated. The former compound has a pronounced larger inhibitory effect than the latter. The trifluormethyl group in bendroflumethiazide has been shown to hydrolyze, with the release of fluoride and hydrogen ions, presumably forming a carboxylic acid. The inhibitory effect of hydrolyzed bendroflumethiazide is found to be similar to the effect of a potassium fluoride solution with the same fluoride ion concentration, as measured by a fluoride selective ion electrode.

1973-01-12·Acta Medica Scandinavica

THE EFFECT OF BENDROFLUMETHIAZIDE ON THE RENAL HANDLING OF CALCIUM, MAGNESIUM AND PHOSPHATE IN NORMOCALCAEMIC RENAL STONE FORMERS AND IN HYPERPARATHYROIDISM

Article

作者: Transbol I ; Jorgensen Fs

Abstract. The effect of bendroflumethiazide (Centyl®) on the renal excretion of calcium, magnesium and phosphate has been investigated in 10 normocalcaemic renal stone formers and 10 hyperparathyroid patients to evaluate the effect of diuretic thiazides on calcium metabolism. A significant increase in the tubular reabsorption of calcium and a significant decrease in the tubular reabsorption of magnesium were observed in both groups. A reduction of 52% in renal calcium excretion was found in both groups, being independent of supposed differences in parathyroid hormone secretion but significantly related to the pretreatment urinary calcium excretion. The renal excretion of magnesium and phosphate increased during thiazide administration. Different theories concerning the mechanisms through which diuretic thiazides act on calcium metabolism are discussed. Based on the present results combined with previous investigations, both a direct effect on tubular calcium reabsorption and an effect on bone metabolism are postulated.

1972-07-01·Acta Pharmacologica et Toxicologica

Effect of a Single, Large Intramuscular Dose of Bendroflumethiazide (Centyl®) on Calcium Metabolism in Rats

Article

作者: F S Jorgensen

A single, large dose of bendroflumethiazide was given intramuscularly in rats to investigate a possible extrarenal effect on calcium metabolism. Neither in normal, parathyroidectomized, thyroidectomized or thyro‐para‐thyroidectomized rats nor by concomitant nephrectomy or parathyroid hormone administration, could any effect of bendroflumethiazide on the serum calcium concentration be demonstrated. The present findings are discussed in relation to previous experiments done in dogs and human subjects which suggested either a stimulating effect on the parathyroid glands or a potentiating effect of the thiazides on the action of the parathyroid hormone.

100 项与苄氟噻嗪/氯化钾相关的药物交易

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