Bone marrow-derived mesenchymal stromal cells(The University of Queensland)(Bone marrow-derived mesenchymal stromal cells(The University of Queensland))

概要

基本信息

药物类型

间充质干细胞疗法

别名

bone marrow-derived mesenchymal stromal cells(The University of Queensland)、Bone-marrow derived MSCs(The University of Queensland)

靶点-

作用方式-

作用机制

细胞替代物

治疗领域

免疫系统疾病

在研适应症

同种异体移植排斥反应

非在研适应症

扩张型心肌病冠心病特发性心肌病+ [1]

原研机构

The University of Queensland

在研机构

The University of Queensland

非在研机构

Hospital General Universitario Gregorio Marañón

Pharmicell Co., Ltd.

权益机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的临床试验

NCT05559801

/ Not yet recruiting临床1/2期IIT

A Phase 1/2 Study to Examine the Safety and Preliminary Efficacy of Mesenchymal Stromal Cells on Linear Growth and Bone Health Parameters in Children With Type 3 Osteogenesis Imperfecta (OI)

This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3. It will evaluate this by looking at whether there are treatment related infusion reactions, and assessing linear growth rates and bone health, both of which are impaired in patients ages 3-10 with Osteogenesis Imperfecta Type 3. This is a single-site non-randomized clinical trial, that will take place at Children's Healthcare of Atlanta (CHOA) at Egleston and Emory Children's Center.

开始日期2025-09-01

申办/合作机构

Emory University

NCT03818737

/ Completed临床3期IIT

Randomized Multicenter Phase 3 Single-blind Trial Comparing the Efficacy of Corticosteroid Control to Mesenchymal Stem Cell Preparations From Autologous Bone Marrow Concentrate (BMAC), Adipose-derived Stem Cells in the Form of Stromal Vascular Fraction (SVF), and Third-party Human Mesenchymal Stem Cells Manufactured From Umbilical Cord Tissue for the Treatment of Unilateral Knee Osteoarthritis (OA)

The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem cells in the form of Stromal Vascular Fraction (SVF), and third-party human mesenchymal stem cells manufactured from umbilical cord tissue (UCT) for the treatment of unilateral Knee Osteoarthritis (OA). The study will be conducted in 4 sites in the United States, and a total of 480 participants will be enrolled in this study.

开始日期2019-03-28

申办/合作机构

Emory University

[+1]

EUCTR2017-003524-75-NL

/ Unknown status临床2期IIT

Allogeneic Bone Marrow Derived Mesenchymal Stromal Cells for the Treatment of Refractory Proctitis in Ulcerative Colitis - BMMSCproctitis

开始日期2018-03-27

申办/合作机构-

100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的临床结果

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的转化医学

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的专利（医药）

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
同种异体移植排斥反应	临床2期	澳大利亚	The University of Queensland	2017-04-21
冠心病	临床2期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-31
特发性心肌病	临床2期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-31
扩张型心肌病	临床2期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-01
酒精性肝硬化	临床1期	美国	Pharmicell Co., Ltd.	2019-06-20

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03818737 (MILES, CTgov)	临床3期	膝关节炎	475	Bone Marrow Derived MSCs (Bone Marrow Derived MSCs)	蓋選糧窪鏇衊製築齋衊(憲鑰積襯觸鏇糧鏇醖築) = 襯糧齋繭鏇壓餘獵廠鏇鑰窪壓觸鹽廠膚鬱遞顧 (廠衊獵餘餘鏇構範遞範, 2.52) 更多	-	2023-07-27
				Adipose-derived MSCs (Adipose-derived MSCs)	蓋選糧窪鏇衊製築齋衊(憲鑰積襯觸鏇糧鏇醖築) = 遞製襯願鏇淵觸簾襯齋鑰窪壓觸鹽廠膚鬱遞顧 (廠衊獵餘餘鏇構範遞範, 2.48) 更多
HOVON-113 (EHA2022) 人工标引	临床3期	类固醇难治性移植物抗宿主病	41	Mesenchymal stromal cell	鑰淵夢範遞願夢鏇醖製(壓齋構鏇蓋憲築製鬱壓) = 餘構淵壓齋膚鬱願憲網鏇齋繭蓋糧艱觸糧繭築 (糧糧窪繭齋選製齋廠夢 ) 更多	不佳	2022-05-12
				placebo	鑰淵夢範遞願夢鏇醖製(壓齋構鏇蓋憲築製鬱壓) = 獵網範餘糧製簾鹹淵願鏇齋繭蓋糧艱觸糧繭築 (糧糧窪繭齋選製齋廠夢 ) 更多