Bone marrow-derived mesenchymal stromal cells(The University of Queensland)(Bone marrow-derived mesenchymal stromal cells(The University of Queensland))

概要

基本信息

药物类型

间充质干细胞疗法

别名

Bone-marrow derived MSCs(The University of Queensland)、bone marrow-derived mesenchymal stromal cells(The University of Queensland)

靶点-

作用方式-

作用机制

细胞替代物

治疗领域

免疫系统疾病

在研适应症

同种异体移植排斥反应

非在研适应症

扩张型心肌病冠心病特发性心肌病+ [1]

原研机构

The University of Queensland

在研机构

The University of Queensland

非在研机构

Hospital General Universitario Gregorio Marañón

Pharmicell Co., Ltd.

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

9

项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的临床试验

NCT05559801

/ Not yet recruiting临床1/2期IIT

A Phase 1/2 Study to Examine the Safety and Preliminary Efficacy of Mesenchymal Stromal Cells on Linear Growth and Bone Health Parameters in Children With Type 3 Osteogenesis Imperfecta (OI)

This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3. It will evaluate this by looking at whether there are treatment related infusion reactions, and assessing linear growth rates and bone health, both of which are impaired in patients ages 3-10 with Osteogenesis Imperfecta Type 3. This is a single-site non-randomized clinical trial, that will take place at Children's Healthcare of Atlanta (CHOA) at Egleston and Emory Children's Center.

开始日期2025-02-01

申办/合作机构

Emory University

NCT05288725

/ Unknown status临床1/2期IIT

A Study to Evaluate the Safety, and Efficacy of Minimally Manipulated Autologous Bone Marrow Aspirate to Treat Knee Osteoarthritis in Patients

The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients. The study compares the effectiveness of an injection of a mesenchymal stem cell preparation from autologous bone marrow aspirate (BMA) to a corticosteroid control for knee osteoarthritis. WOMAC, VAS pain scores, and MRI will be used for assessment. The study will be conducted at 3 sites in the United States.

开始日期2022-08-01

申办/合作机构

Next Generation Regenerative Medicine LLC

ACTRN12620000840987

/ Recruiting临床1期IIT

Phase I trial on safety and tolerability of bone-marrow derived mesenchymal stromal cells (MSC) for deteriorating COVID-19 pneumonia

开始日期2020-05-05

申办/合作机构-

100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的临床结果

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的转化医学

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的专利（医药）

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100 项与 Bone marrow-derived mesenchymal stromal cells(The University of Queensland) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
酒精性肝硬化	临床3期	美国	Pharmicell Co., Ltd.	2019-06-20
冠心病	临床3期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-31
特发性心肌病	临床3期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-31
扩张型心肌病	临床3期	西班牙	Hospital General Universitario Gregorio Marañón	2013-03-01
同种异体移植排斥反应	临床2期	澳大利亚	The University of Queensland	2017-04-21

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临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03818737 (MILES, CTgov)	临床3期	膝关节炎	475	Bone Marrow Derived MSCs (Bone Marrow Derived MSCs)	築憲廠積獵觸繭顧壓鬱(淵憲繭淵淵餘遞膚廠壓) = 觸醖餘醖繭鹽鬱顧窪窪築範蓋鬱繭膚獵積壓窪 (餘遞觸築醖積廠觸鬱壓, 願艱艱蓋鹹廠顧醖觸觸 ~ 壓蓋顧夢夢構廠廠齋範) 更多	-	2023-07-27
				Adipose-derived MSCs (Adipose-derived MSCs)	築憲廠積獵觸繭顧壓鬱(淵憲繭淵淵餘遞膚廠壓) = 願獵願築觸選窪鬱膚繭築範蓋鬱繭膚獵積壓窪 (餘遞觸築醖積廠觸鬱壓, 衊遞淵鬱醖齋顧願蓋醖 ~ 淵簾憲壓觸積選顧醖簾) 更多