多种油脂肪乳（C6-24）(Multi-oil Fat Emulsion)

概要

基本信息

药物类型

小分子化药

别名

Multi-oil Fat Emulsion Injection(C6-24)、多种油脂肪乳、多种油脂肪乳（C6~24）

靶点-

作用机制-

治疗领域-

在研适应症-

非在研适应症-

原研机构

Fresenius Kabi Austria GmbH

在研机构

Fresenius Kabi Austria GmbH

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (2017-01-01)

最高研发阶段(中国)批准上市

特殊审评-

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关联

1

项与多种油脂肪乳（C6-24）相关的临床试验

ChiCTR1800017346 / Recruiting临床4期IIT

A Prospective Multicenter, Randomized, Double-blinded, Active Controlled, Pilot Clinical Study: Efficacy and Safety of Multi-oil Fat Emulsion Injection (C6-24) (20% SMOFlipid) in Critically Ill Patients

开始日期2019-01-01

申办/合作机构

中山大学

100 项与多种油脂肪乳（C6-24）相关的临床结果

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100 项与多种油脂肪乳（C6-24）相关的转化医学

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100 项与多种油脂肪乳（C6-24）相关的专利（医药）

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1

项与多种油脂肪乳（C6-24）相关的文献（医药）

2006-01-01·Biological and Pharmaceutical Bulletin4区 · 医学

Soybean Oil Fat Emulsion to Prevent TPN-Induced Liver Damage: Possible Molecular Mechanisms and Clinical Implications

4区 · 医学

Review

作者: Yamauchi, Aiko ; Nishimura, Masuhiro ; Naito, Shinsaku ; Yamaguchi, Mari

Long-term total parenteral nutrition (TPN) is known to be associated with cholestasis and hepatic steatosis, which can be lethal in infants who cannot be fed orally. The present review focuses on the metabolic complications in the liver that may occur due to the excessive administration of fat-free TPN. We have recently developed an infant rat model of hepatic dysfunction and steatosis induced by overdose of fat-free TPN. In this model, plasma levels of liver enzymes in the fat-free TPN group were found to be significantly higher than in the other groups (i.e., the oral diet and fat-containing TPN groups). Pathological examination showed hepatomegaly and severe fatty changes without cholestasis in the liver of infant rats that received fat-free TPN. We clearly demonstrated that the addition of soybean oil emulsion to the TPN regimen prevented hepatic dysfunction and fatty changes. In the present review, we discuss the molecular mechanism of the hepatic dysfunction induced by fat-free TPN and the role of soybean oil fat emulsion in the TPN regimen. We also discuss the clinical implications of soybean oil-containing TPN solutions and point out the importance of including fat in the TPN regimen in order to prevent the hepatic abnormalities associated with the excessive administration of fat-free TPN.

100 项与多种油脂肪乳（C6-24）相关的药物交易

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