A multicentre, open-label, Phase I study investigating the safety, tolerability, and efficacy of 177Lu-SSO110 with 68Ga-SSO120 companion imaging in participants with extensive stage small cell lung cancer (ES-SCLC) who are on maintenance treatment with immune checkpoint inhibition (The LuSato1 Study).

开始日期2023-06-30

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100 项与 SSO-120 相关的临床结果

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100 项与 SSO-120 相关的转化医学

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项与 SSO-120 相关的文献（医药）

2024-01-01·Theranostics

Theranostics with somatostatin receptor antagonists in SCLC: Correlation of ⁶⁸Ga-SSO120 PET with immunohistochemistry and survival

Article

作者: Mavroeidi, Ilektra Antonia ; Nader, Michael ; Kersting, David ; Wienker, Johannes ; Bölükbas, Servet ; Theegarten, Dirk ; Hautzel, Hubertus ; Romanowicz, Anna ; Oezkan, Filiz ; Stuschke, Martin ; Haake, Tristan ; Umutlu, Lale ; Opitz, Marcel ; Herrmann, Ken ; Fendler, Wolfgang P. ; Schuler, Martin ; Fendler, Wolfgang P ; Winantea, Jane ; Hamacher, Rainer ; Eberhardt, Wilfried E E ; Metzenmacher, Martin ; Eberhardt, Wilfried E. E. ; Siveke, Jens ; Darwiche, Kaid ; Wiesweg, Marcel

Rationale: Positron Emission Tomography (PET) using the somatostatin receptor 2 (SSTR2)-antagonist satoreotide trizoxetan (⁶⁸Ga-SSO120) is a novel, promising imaging modality for small-cell lung cancer (SCLC), which holds potential for theranostic applications. This study aims to correlate uptake in PET imaging with SSTR2 expression in immunohistochemistry (IHC) and to assess the prognostic value of ⁶⁸Ga-SSO120 PET at initial staging of patients with SCLC. Methods: We analyzed patients who underwent ⁶⁸Ga-SSO120 PET/CT during initial diagnostic workup of SCLC as part of institutional standard-of-care. SSTR2 expression in IHC was evaluated on a 4-level scale and correlated with normalized standardized uptake values and tumor-to-liver ratios (SUV_max and TLR_peak) in ⁶⁸Ga-SSO120 PET on a lesion level. Highest lesion SUV_max/TLR_peak per patient, SSTR2 score in IHC, M status according to TNM classification, and other parameters were analyzed for association with overall survival (OS) and time to treatment failure (TTF) by univariate, multivariate (cut-off values were identified on data for best separation), and stratified Cox regression. Results: We included 54 patients (24 men/30 women, median age 65 years, 21 M0/33 M1 according to TNM classification). In 43 patients with available surplus tumor tissue samples, hottest lesion SUV_max/TLR_peak showed a significant correlation with the level of SSTR2-expression by tumor cells in IHC (Spearman's rho 0.86/0.81, both p < 0.001; ANOVA p < 0.001). High SSTR2 expression in IHC, ⁶⁸Ga-SSO120 SUV_max and TLR_peak of the hottest lesion per patient, whole-body TLR_mean, MTV, TLG, M status, and serum LDH showed a significant association with inferior TTF/OS in univariate analysis. In separate multivariate Cox regression (including sex, age, M stage, and LDH) higher hottest-lesion TLR_peak showed a significant association with shorter OS (HR = 0.26, 95%CI: 0.08-0.84, p = 0.02) and SSTR2 expression in IHC with significantly shorter TTF (HR = 0.24, 95%CI: 0.08-0.71, p = 0.001) and OS (HR = 0.22, 95%CI: 0.06-0.84, p = 0.03). In total, 12 patients (22.2%) showed low (< 1), 21 (38.9%) intermediate (≥ 1 but < 2), 14 (25.9%) high (≥ 2 but < 5), and 7 (13.0%) very high (≥ 5) whole-body mean TLR_mean. Conclusion: In patients with SCLC, SSTR2 expression assessed by ⁶⁸Ga-SSO120 PET and by IHC were closely correlated and associated with shorter survival. More than 75% of patients showed higher whole-body ⁶⁸Ga-SSO120 tumor uptake than liver uptake and almost 40% high or very high uptake, possibly paving the way towards theranostic applications.

2017-12-01·Ecology and Evolution2区 · 生物学

Establishing the phylogeny of Prochlorococcus with a new alignment‐free method

2区 · 生物学

ArticleOA

作者: Yau, Stephen S.‐T. ; He, Rong L. ; Tian, Kun ; Zhao, Xin

AbstractProchlorococcus marinus, one of the most abundant marine cyanobacteria in the global ocean, is classified into low‐light (LL) and high‐light (HL) adapted ecotypes. These two adapted ecotypes differ in their ecophysiological characteristics, especially whether adapted for growth at high‐light or low‐light intensities. However, some evolutionary relationships of Prochlorococcus phylogeny remain to be resolved, such as whether the strains SS120 and MIT9211 form a monophyletic group. We use the Natural Vector (NV) method to represent the sequence in order to identify the phylogeny of the Prochlorococcus. The natural vector method is alignment free without any model assumptions. This study added the covariances of amino acids in protein sequence to the natural vector method. Based on these new natural vectors, we can compute the Hausdorff distance between the two clades which represents the dissimilarity. This method enables us to systematically analyze both the dataset of ribosomal proteomes and the dataset of 16s‐23s rRNA sequences in order to reconstruct the phylogeny of Prochlorococcus. Furthermore, we apply classification to inspect the relationship of SS120 and MIT9211. From the reconstructed phylogenetic trees and classification results, we may conclude that the SS120 does not cluster with MIT9211. This study demonstrates a new method for performing phylogenetic analysis. The results confirm that these two strains do not form a monophyletic clade in the phylogeny of Prochlorococcus.

2003-08-19·Proceedings of the National Academy of Sciences1区 · 综合性期刊

Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome

1区 · 综合性期刊

Article

作者: Dufresne, Alexis ; Le Gall, Florence ; Galperin, Michael Y. ; Makarova, Kira S. ; Artiguenave, François ; Axmann, Ilka M. ; Partensky, Frédéric ; Koonin, Eugene V. ; de Marsac, Nicole Tandeau ; Robert, Catherine ; Salanoubat, Marcel ; Wincker, Patrick ; Rogozin, Igor B. ; Weissenbach, Jean ; Oztas, Sophie ; Ostrowski, Martin ; Duprat, Simone ; Barbe, Valérie ; Hess, Wolfgang R. ; Scanlan, David J. ; Wolf, Yuri I.

Prochlorococcus marinus , the dominant photosynthetic organism in the ocean, is found in two main ecological forms: high-light-adapted genotypes in the upper part of the water column and low-light-adapted genotypes at the bottom of the illuminated layer. P. marinus SS120, the complete genome sequence reported here, is an extremely low-light-adapted form. The genome of P. marinus SS120 is composed of a single circular chromosome of 1,751,080 bp with an average G+C content of 36.4%. It contains 1,884 predicted protein-coding genes with an average size of 825 bp, a single rRNA operon, and 40 tRNA genes. Together with the 1.66-Mbp genome of P. marinus MED4, the genome of P. marinus SS120 is one of the two smallest genomes of a photosynthetic organism known to date. It lacks many genes that are involved in photosynthesis, DNA repair, solute uptake, intermediary metabolism, motility, phototaxis, and other functions that are conserved among other cyanobacteria. Systems of signal transduction and environmental stress response show a particularly drastic reduction in the number of components, even taking into account the small size of the SS120 genome. In contrast, housekeeping genes, which encode enzymes of amino acid, nucleotide, cofactor, and cell wall biosynthesis, are all present. Because of its remarkable compactness, the genome of P. marinus SS120 might approximate the minimal gene complement of a photosynthetic organism.

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适应症	最高研发状态	国家/地区	公司	日期
神经母细胞瘤	临床1期	德国	Ariceum Therapeutics GmbH初创企业	2022-07-21
实体瘤	临床1期	德国	Ariceum Therapeutics GmbH初创企业	2022-07-21

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SNMMI2023	N/A	小细胞肺癌	-	68Ga-SSO-12068Ga-Satoreotide (68Ga-SSO-120 PET/CT)	艱鹹齋範簾鬱膚網範積(壓艱繭鬱願網壓膚憲窪) = 壓艱蓋選衊醖襯糧構觸構範獵糧繭遞淵壓顧廠 (觸鏇鏇願積鏇顧醖醖築 ) 更多	-	2023-08-28
				FDG68Ga-Satoreotide (FDG PET/CT)	襯觸繭糧夢鹽蓋夢願觸(夢艱繭廠襯鹹憲顧糧憲) = 顧鏇遞願網鬱築醖壓夢鹹糧築衊鏇觸鑰築鹹鬱 (簾餘齋淵觸積鏇網窪鏇 ) 更多