奥芬达唑(Oxfendazole) - 在研适应症：神经系统囊虫病，片形吸虫病，鞭虫病_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(5-(phenylsulfinyl)-1H-benzimidazol-2-yl)carbamic acid methyl ester、5-(phenylsulfinyl)-2-benzimidazolecarbamic acid methyl ester、5-phenylsulfinyl-2-carbomethoxyaminobenzimidazole

+ [8]

靶点-

作用方式-

作用机制-

治疗领域

感染神经系统疾病其他疾病+ [3]

在研适应症

神经系统囊虫病片形吸虫病鞭虫病+ [3]

非在研适应症-

原研机构

National Institute of Allergy & Infectious Diseases

在研机构

The Oxfendazole Development Group

Drugs for Neglected Diseases initiative

Universidad Peruana Cayetano Heredia

+ [1]

非在研机构-

最高研发阶段临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

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结构/序列

分子式C15H13N3O3S

InChIKeyBEZZFPOZAYTVHN-UHFFFAOYSA-N

CAS号53716-50-0

关联

9

项与奥芬达唑相关的临床试验

NCT06367361

/ Not yet recruiting临床2期IIT

Non-inferiority, Controlled, Randomized, Single-blind Study for Compare Regimens of One and Two Doses of Oxfendazole Versus a Schedule of Two Doses of Triclabendazole to Treat Chronic Fascioliasis

Randomized clinical trial comparing the efficacy and safety of oxfendazole at 20 mg/kg per dose in one and two dose regimens with a two-dose regimen of triclabendazole at 10 mg/kg in an endemic region of the highlands of Peru. Children and adults with fascioliasis in rural communities will be screened for inclusion and exclusion criteria and a total of 336 subjects (112 per study arm) with chronic Fasciola infection will be enrolled and assigned randomly to the study arms in a 1:1:1 ratio. The primary efficacy (cure and egg reduction) endpoints will be assessed on day 7 and 30 post treatment. The secondary safety endpoint visits will be performed in days 0, 3, 7 and 30 post-treatment and Population Pharmacokinetics (PK) modeling studies will be performed in the first 24 hours after the first dose of oxfendazole.

开始日期2025-01-30

申办/合作机构

Universidad Peruana Cayetano Heredia

[+2]

NCT06565507

/ Not yet recruiting临床2/3期IIT

A Double-blind Multicenter, Randomized Controlled Trial of Single and Multiple Dose Regimens of Oxfendazole for Mild (One or Two Lesions) Parenchymal Brain Cysticercosis, With an Open Comparison Group

The goal of this clinical trial is to compare a single and multiple dose regimens of oxfendazole with the standard treatment in patients with mild (one or two lesions) parenchymal brain cisticercosis. The main question it aims to answer is if OXF will enhance clearance of brain parasites and therefore provide greater cysticidal efficacy, with the potential to provide a single-dose therapy for this type of NCC.
The study cohort will also allow us to identify early imaging markers that predict lesion resolution, as well as factors associated with residual calcification or focal gliosis after lesion resolution. This study will also provide additional information on the safety of the study interventions.

开始日期2024-12-15

申办/合作机构

Universidad Peruana Cayetano Heredia

[+1]

NCT03435718

/ Not yet recruiting临床2期IIT

An Assessor Blind, Randomized, Comparative Study of the Efficacy of Different Doses of Oxfendazole Compared to Single Dose Albendazole in the Treatment of Trichuris Trichiura Infection in Adults

The main objective of this study is to provide data on the efficacy profile of different doses of oxfendazole when used in Trichuris trichiura infection. The drug will be also be examined for efficacy against other common nematodes encountered in man (Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus). The study will also provide data on the safety and tolerability of the oxfendazole in patients.

开始日期2024-07-01

申办/合作机构

The Oxfendazole Development Group

[+1]

100 项与奥芬达唑相关的临床结果

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100 项与奥芬达唑相关的转化医学

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100 项与奥芬达唑相关的专利（医药）

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2,070

项与奥芬达唑相关的文献（医药）

2025-04-01·International Journal for Parasitology: Drugs and Drug Resistance

Efficacy of fenbendazole against gastrointestinal nematodes in naturally infected goats in Maputo Province, Mozambique using in vivo, in vitro and molecular assessment

Article

作者: Krücken, Jürgen ; Afonso, Sonia M S ; Borchert, Marc ; Atanásio, Alsácia ; von Samson-Himmelstjerna, Georg ; Guinda, Edna F X ; Morgan, Eric R ; Capece, Bettencourt P S ; Ramünke, Sabrina ; Fiedler, Stefan

Anthelmintic resistance occurs worldwide in strongyles of ruminants but data from low-income countries are sparse and rarely apply most up to date methods, while effects of management practices in these countries are poorly documented. In Mozambique, benzimidazole resistance has been previously reported; the present study followed this up in detail, applying in vivo faecal egg count (FEC) reduction test (FECRT), in vitro egg hatch test (EHT) and molecular deep amplicon sequencing approaches targeting the internal transcribed spacer 2 (ITS-2, nemabiome) and the isotype 1 β-tubulin gene to determine the resistance status on farms and the strongyle species involved. Adult Landim goats (433) from six semi-intensive and ten extensive farms (22-30 animals/farm) from Maputo Province were visited April 2021 to February 2022. Fenbendazole (5 mg/kg bw, Panacur®) was administered orally and FEC determined using Mini-FLOTAC. The eggCounts package was used to calculate FECRs with 90% confidence intervals from paired day 0 and 14 data. In vivo and in vitro tests detected AR on 5/16 (31%) farms. This included 1/10 extensive and 4/6 semi-intensive farms. The odds of finding resistant strongyles on a semi-intensive commercial farm was 40-fold higher than on an extensive farm (p = 0.016, logistic regression). A strong, negative correlation was observed between FECRT and EHT EC₅₀ values (Pearson's R = -0.83, P = 0.001; Cohen's κ coefficient 1.0). Nemabiome data showed that Haemonchus contortus, Trichostrongylus colubriformis and unclassified Oesophagostomum closely related to Oesophagostomum columbianum were most abundant before treatment and in particular H. contortus frequencies increased after treatment. Benzimidazole resistance associated polymorphisms were detected in H. contortus and T. colubriformis. Moreover, there were hints that resistance alleles were present in Trichostrongylus axei and Teladorsagia circumcincta. Farmers should regularly test the efficacy of anthelmintics used and consider more sustainable worm control approaches to reduce selection for resistance.

2025-02-01·Environmental Toxicology and Chemistry

Spatial occurrence of emerging contaminants in rivers and wastewater. Analysis of environmental and human risks

Article

作者: Teglia, Carla Mariela ; Machado, Selva ; Goicoechea, Héctor Casimiro ; Maine, María Alejandra ; Hadad, Hérnan Ricardo ; Gutierrez, Fabiana Andrea

AbstractThis study assesses the occurrence of emerging contaminants (ECs) from agricultural and livestock production activities along the Salado River (Santa Fe province, Argentina). Of the 23 ECs studied, 8 were detected and quantified in river and wastewater samples, including ciprofloxacin, enrofloxacin, chlorpyrifos-methyl, albendazole, fenbendazole, levamisole, diazepam, and thiamethoxam. In river samples, the highest concentrations corresponded to ciprofloxacin, chlorpyrifos-methyl, and enrofloxacin. In wastewater samples, albendazole, fenbendazole, ciprofloxacin, enrofloxacin, and thiamethoxam were found. The detection frequency ranged from 4.2% to 54.2% in river samples and from 11.1% to 22.2% in wastewater samples. The spatial distribution of contaminants showed different concentrations, with higher levels often found near urban and agricultural areas, suggesting anthropogenic sources. Ecological risk assessments for different organisms were conducted. Ciprofloxacin posed the highest risk, especially affecting bacteria, cyanobacteria, and algae. Diazepam also was found to pose significant risks to algae, crustaceans, and fishes. Chlorpyrifos-methyl was identified as highly hazardous to multiple living organisms, which is in agreement with the fish mortality that occurred at the sampling sites. The risk assessment in humans showed differences among children, adolescents, and adults, with infants (6 months to 1 year) being at a higher risk than adults. Children may be at a higher daily intake of contaminants than adults, raising concerns about the long-term effects of exposure. This work underscores the critical need for monitoring and regulating ECs in aquatic environments. Further studies are necessary to fully understand their impact and to develop effective strategies for mitigating their presence in water systems.

2025-02-01·Research in Veterinary Science

Survey on canine hookworms: Knowledge, perceptions and practices among U.S. veterinarians

Article

作者: Miller, Kamilyah R ; Hanzlicek, Gregg A ; Jesudoss Chelladurai, Jeba R J ; Ochoa, Sara J ; Kastner, Justin

Canine hookworms (Ancylostoma caninum) are highly prevalent in pet dogs in the United States of America (U.S.). They pose a significant health risk to infected dogs and are also a potential risk to humans as zoonotic agents. Veterinarians play a crucial role in managing this threat through the diagnosis and treatment of infections in pet dogs. However, the rising incidence of anthelmintic resistance in U.S. hookworm populations necessitates increased awareness among veterinarians. To determine U.S. veterinarian's knowledge, perceptions and practices about canine hookworms, a cross-sectional online survey was administered between February and December 2022. 208 veterinarians from 43 states participated in the study. Only 65 % of veterinarians reported awareness of hookworm prevalence. Hookworm infected dogs were encountered more frequently in the South than in Western states. Veterinarians perceived that hookworms were present in all breeds without breed predilection followed by mixed breeds, pit bulls and hound breeds. Most respondents reported that infections were rarely symptomatic, highlighting the importance of diagnostic testing. In-clinic diagnostic modalities were most preferred. Fenbendazole and pyrantel pamoate were the most commonly used anthelmintics. Most veterinarians followed up on infected dogs but retesting time after treatment varied. Awareness of multi-drug resistant hookworms was high but encountering persistent hookworm cases was lower. Veterinarians frequently educated clients about hookworms and prevention, but less about the zoonotic potential. This study provides insights for improving awareness, diagnostics, treatment protocols, and client education regarding canine hookworms in the U.S.. Overall, veterinarians play an active role in hookworm prevention and control.

100 项与奥芬达唑相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D05291	奥芬达唑	-	DB11446

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
神经系统囊虫病	临床3期	-	The Oxfendazole Development Group	2024-12-15
神经系统囊虫病	临床3期	-	Universidad Peruana Cayetano Heredia	2024-12-15
片形吸虫病	临床2期	-	National Institute of Allergy & Infectious Diseases	2025-01-30
鞭虫病	临床2期	-	The Oxfendazole Development Group	2024-07-01
丝虫病	临床1期	坦桑尼亚	Drugs for Neglected Diseases initiative	2022-04-21
眼盘尾丝虫病	临床1期	瑞士	Drugs for Neglected Diseases initiative	2022-01-30
蠕虫病	临床1期	美国	The Oxfendazole Development Group	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03035760 (CTgov)	临床1期	蠕虫病	36	Oxfendazole (Arm 1: 3 mg/kg Oxfendazole for 5 Days)	鑰積鬱壓網遞餘積範觸(憲憲鏇觸選蓋鹹蓋餘壓) = 糧積鹽鏇獵衊餘餘憲鹽構鏇夢願鑰願夢鏇艱築 (積構製鑰鬱餘範製繭衊, 襯糧繭選鬱築夢範蓋鹹 ~ 襯築餘網醖簾獵糧選選) 更多	-	2019-12-17
				Oxfendazole (Arm 2: 7.5 mg/kg Oxfendazole for 5 Days)	鑰積鬱壓網遞餘積範觸(憲憲鏇觸選蓋鹹蓋餘壓) = 範遞鬱壓鬱醖築窪鑰鏇構鏇夢願鑰願夢鏇艱築 (積構製鑰鬱餘範製繭衊, 蓋構廠網構齋鹹鏇鬱膚 ~ 壓憲獵壓積膚壓遞選淵) 更多
NCT02234570 (CTgov)	临床1期	神经系统囊虫病	70	Oxfendazole (0.5 mg/kg Oxfendazole)	鏇選顧範遞鹽鹽獵窪獵(遞夢壓醖鑰顧製範廠選) = 廠範鏇醖獵築範鑰鹽蓋願憲蓋壓積襯積廠齋餘 (積遞膚醖願積壓繭夢製, 衊廠範糧遞鬱壓範窪積 ~ 願衊窪網願鑰構築鏇繭) 更多	-	2019-11-26
				Oxfendazole (1 mg/kg Oxfendazole)	鏇選顧範遞鹽鹽獵窪獵(遞夢壓醖鑰顧製範廠選) = 構獵築顧夢願簾鹽醖淵願憲蓋壓積襯積廠齋餘 (積遞膚醖願積壓繭夢製, 壓製遞蓋選窪鬱構繭醖 ~ 壓願鏇鬱繭衊鏇憲範膚) 更多
NCT02234570 (Pubmed \| Antimicrob Agents Chemother)	临床1期	-	70	Oxfendazole	(衊壓窪齋蓋衊簾蓋醖夢) = dose-dependent decrease 選範齋鹹遞鹽襯醖蓋齋 (構鹹製膚獵鑰窪築壓壓 ) 更多	-	2019-04-01