Orilotimod potassium

A new approach to microbiol. anal. of several pharmaceuticals, in particular, those that can be used in manufacturing sterile medical products, is presented.The proposed approach was verified using a series of 23 samples of various products, three of which were obtained by biotechnol. methods.The scheme includes inoculation of samples with test strains followed by isolation and anal. of the contaminants.Validation results showed that the amount of products for microbiol. anal. could be reduced to 3 g, which was sufficient for obtaining reliable results.Tryptic soy broth was used as the solvent (diluent) and enrichment broth for microbe growth.

We studied the status of proliferation processes (by Ki-67 expression) and biogenesis of free radicals (by chemiluminescence method) in skin biopsy specimens from patients with atopic dermatitis and lichen planus. The index of Ki-67-positive nuclei significantly (p<0.05) increased to 28.40±2.00% in patients with dermatitis and to 32.6±1.9% in patients with lichen planus vs. 8.65±1.31% in the reference sample. Decompensated accumulation of free-radical oxidation products and inhibition of detoxification systems in skin biopsy specimens indicate the development of local oxidative stress. After therapy consisting of two 10-day courses of thymodepressin injections (0.1%, 1.0 ml) over 30 days, normalization of epidermis proliferation was observed. Labeling index in atopic dermatitis and lichen planus significantly decreased (p<0.05) to 17.00±1.87 and 10.9±1.1%, respectively. The role of free radicals in the development of hyperregeneratory processes during dermatoses is discussed.