JBP-1(JBP-1) - 药物靶点：Trypsin x amylase_专利_临床

概要

基本信息

药物类型

酶

别名

trypsinogen/chymotrypsinogen/amylase (Propanc)

靶点

Trypsin x amylase

作用机制

S1: Chymotrypsin stimulants、胰蛋白酶刺激剂、amylase刺激剂(淀粉酶刺激剂)

治疗领域

肿瘤

在研适应症-

非在研适应症

肿瘤

原研机构

Propanc Biopharma, Inc.

在研机构-

非在研机构

Propanc Biopharma, Inc.

最高研发阶段终止药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 JBP-1 相关的临床结果

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100 项与 JBP-1 相关的转化医学

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100 项与 JBP-1 相关的专利（医药）

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1

项与 JBP-1 相关的文献（医药）

2013-11-01·Journal of Asian Natural Products Research4区 · 医学

Structure characterization and immunocompetence of a glucan from the fruiting bodies of Cantharellus cibarius

4区 · 医学

Article

作者: Ko, Chun-Hay ; Tu, Peng-Fei ; Han, Xiao-Qiang ; Han, Chun-Xia ; Gao, Xiao-Ming ; Li, Wei-Ji

A protein-bound polysaccharide fraction (JBP-1) was obtained from the fruiting bodies of Cantharellus cibarius. Its chemical composition was studied by the cooperative usage of multiple chemical and spectral methods and characterized to be a fraction with a molecular weight of 4.8 × 10(5) Da and only composed of glucose. Methylation analysis revealed that the sugar residues in JBP-1 are existing as t-, 1,6-, and 1,3,6-linked Glcp sugar residues. The immunocompetence of the fraction was evaluated with the proliferation assay of mouse splenocytes, and the result revealed that JBP-1 could significantly stimulate the proliferation of mouse splenocytes in a dose-dependent manner, with p < 0.001 at the concentration of 100 μg/ml and 30 μg/ml, p < 0.05 at 10 μg/ml. These results give us a primary scientific evidence to further explore the pharmaceutical function of this mushroom.

100 项与 JBP-1 相关的药物交易

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