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更新于：2025-05-07

LC-9018

更新于：2025-05-07

概要

概要

基本信息

药物类型

小分子化药

别名

Lemonal、PS PG

+ [4]

靶点-

作用方式

刺激剂

作用机制

免疫刺激剂

治疗领域

肿瘤感染

在研适应症-

非在研适应症

细菌感染肿瘤

原研机构

Yakult Honsha Co., Ltd.

在研机构-

非在研机构

Yakult Honsha Co., Ltd.

权益机构-

最高研发阶段终止申请上市

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

100 项与 LC-9018 相关的临床结果

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100 项与 LC-9018 相关的转化医学

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100 项与 LC-9018 相关的专利（医药）

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项与 LC-9018 相关的文献（医药）

2002-09-01·Journal of Surgical Research4区 · 医学

Effect of Lactobacillus casei on a Novel Murine Model of Abdominal Sepsis

4区 · 医学

Article

作者: Makoto Watanabe ; Akira Tsunoda ; Yuko Tsunoda ; Miki Shibusawa ; Koji Nomoto ; Mitsuo Kusano

BACKGROUNDLactobacilli are one of the probiotics and there is strong evidence for the efficacy of lactobacilli administration as a nonspecific immunostimulant in increasing host defense mechanisms. The present study tested the hypothesis that heat-killed Lactobacillus casei (LC9018) has a protective activity against fecal peritonitis.METHODSCecal ligation and tip resection (CLTR) induced fecal peritonitis was developed as a novel mouse model of abdominal sepsis, and the effects of LC9018 pretreatment on survival after CLTR, of the peritoneal exudate cells before or after CLTR and of bacterial growth in the peritoneal cavity after CLTR were investigated.RESULTSMortality after CLTR varied directly with the length of the opened bowel. To obtain a sublethal experimental group, the length of the opened bowel was fixed at 4 mm, where mortality was 87%, for further experiments. Survival of mice after CLTR was augmented in mice that had been pretreated intraperitoneally (ip) with LC9018 24 h previously. Viable bacterial growth in the peritoneal cavity was markedly inhibited in LC9018-pretreated mice. Peritoneal exudate cell accumulation observed 24 h after ip injection of LC9018 was significantly enhanced, suggesting that augmentation of the resistance of mice to CLTR was caused especially by the induction of polymorphonuclear cells.CONCLUSIONSCLTR may provide a reproducible and simple murine model of bacterial sepsis and pretreatment with LC9018 developed a protective activity against CLTR surgery.

2001-12-01·Journal of Urology1区 · 医学

ANTITUMOR EFFECTS OF THE INTRAVESICAL INSTILLATION OF HEAT KILLED CELLS OF THE LACTOBACILLUS CASEI STRAIN SHIROTA ON THE MURINE ORTHOTOPIC BLADDER TUMOR MBT-2

1区 · 医学

Article

作者: AKAZA, HIDEYUKI ; MOROTOMI, MASAMI ; KUSHIRO, AKIRA ; NOMOTO, KOJI ; UCHIDA, KAZUMI ; TAKAHASHI, TAKUYA ; YOKOKURA, TERUO

PURPOSETo characterize the potential of heat killed Lactobacillus casei, Shirota strain (LC9018), as an alternative to bacillus Calmette-Guerin (BCG) for treating patients with bladder cancer we investigated the antitumor effects of intravesical instillation of LC9018 in the MBT-2 orthotopic bladder tumor implantation model in C3H/He mice.MATERIALS AND METHODSLC9018 or BCG, Tokyo 172 strain, was instilled once daily for 10 days starting on the day after orthotopic implantation of MBT-2. Tumor appearance and mean bladder weight on day 21 after tumor implantation were evaluated. Moreover, we investigated the augmentation of local cellular immunity in bladder mucosa by immunohistochemical staining and reverse transcription polymerase chain reaction.RESULTSIntravesical LC9018 instillation significantly reduced the rate of tumor appearance in 8 of 38 subjects (p <0.001) and mean tumor growth plus or minus standard deviation with a bladder weight of 37 +/- 49 mg. (p <0.001) compared with tumor appearance in 41 of 58 subjects and mean bladder weight 146 +/- 183 mg. in controls. BCG had no significant antitumor activity in the orthotopic implantation model. Intravesical instillation of LC9018 augmented the local expression of antitumor cytokine messenger RNA (interferon-gamma and tumor necrosis factor-alpha) and induced the infiltration of neutrophils surrounded by macrophages that phagocytosed LC9018 cells at the bladder mucosa.CONCLUSIONSThese results suggest that LC9018 is potentially more potent and safer as a therapeutic agent than BCG for superficial bladder tumors. Furthermore, the antitumor effect of LC9018 is exerted via the augmentation of local cell mediated antitumor immunity.

1999-08-23·Medical Microbiology and Immunology4区 · 医学

The role of tumor necrosis factor (TNF)-? in the antitumor effect of intrapleural injection of Lactobacillus casei strain Shirota in mice

4区 · 医学

Article

作者: Yasunobu Yoshikai ; Teruo Yokokura ; Takeshi Matsuzaki ; Nobuyoshi Yasutake ; Keiko Kimura ; Shusuke Hashimoto

The involvement of several cytokines in the antitumor effect induced by intrapleural (i.pl.) injection of heat-killed cells of Lactobacillus casei strain Shirota (LC 9018) in mice was investigated. Injection of LC 9018 i.pl. into Meth A fibrosarcoma (Meth A)-bearing mice not only significantly prolonged the survival of the mice, but also effectively inhibited the accumulation of malignant pleural fluid in the thoracic cavity. In the thoracic cavity of tumor-bearing mice treated with LC 9018, we observed large amounts of several cytokines including interleukin (IL)-1beta, interferon (IFN)-gamma, IL-12 and tumor necrosis factor (TNF)-alpha. Both anti-IFN-gamma and anti-IL-12 monoclonal antibody (mAb) treatments partially diminished the antitumor activity of LC 9018 in vivo, while the treatment of anti-IL-1beta mAb did not influence the survival of the mice. However, anti-TNF-alpha mAb treatment completely abolished the antitumor effect of LC 9018 in vivo, suggesting that in this model LC 9018 has a survival-prolonging effect involving certain cytokines. Moreover, i.pl. injection of mouse recombinant TNF-alpha into Meth A-bearing mice pretreated with anti-TNF-alpha mAb partially restored the survival-enhancing effect of LC 9018. These results led us to conclude that TNF-alpha induced by i.pl. injection of LC 9018 plays an important role in the antitumor effect of LC 9018 in vivo.

100 项与 LC-9018 相关的药物交易

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