Administration of HIV-specific T Cells to HIV+ Patients Receiving High Dose Chemotherapy Followed by Autologous Stem Cell Rescue - Auto -RESIST BMT CTN 1903

This is a Phase II multi-center trial single arm trial of autologous transplantation (ASCT) followed by administration of HST-NEETs for treatment of HIV associated lymphoma

开始日期2021-10-25

申办/合作机构

National Heart, Lung & Blood Institute

[+5]

NCT04248192 / Recruiting临床1期IIT

A Study to Evaluate the Safety, Immunologic, and Virologic RESponses of Donor Derived (DD) HIV-Specific T-cells (HST) With Non-escaped Epitope Targeting (NEETs) in HIV-Infected Individuals on Antiretroviral Therapy Following Allogeneic Bone Marrow Transplantation (alloRESIST)

This is a multi-site phase 1 study of the safety, immunologic and virologic responses of ex vivo expanded donor-derived (DD) HIV-1 multi-antigen specific T-cell (HST) with non-escaped epitope targeting (NEET) therapy as a therapeutic strategy in HIV-infected individuals following Allogeneic Bone Marrow Transplantation (alloBMT).

开始日期2020-05-01

申办/合作机构

Children's National Research Institute

NCT03485963 / Active, not recruiting临床1期IIT

A Phase I Study to Evaluate the Safety, Immunologic, and Virologic RESponses of HIV-Specific T-cells With Non-escaped Epitope Targeting (HST-NEETs) as a Therapeutic Strategy in HIV-Infected Individuals on Antiretroviral Therapy During Acute And Chronic Infection

This is a phase I, multi-site, study of the safety, immunologic and virologic responses of ex vivo expanded HIV-1 multi-antigen specific T-cell therapy (HST-NEET) as a therapeutic strategy in HIV-infected individuals suppressed on antiretroviral therapy (ART).

开始日期2019-03-21

申办/合作机构

Children's National Research Institute

100 项与 Donor Derived HIV-Specific T-cells (DD HST-NEETs)(Children's National Research Institute) 相关的临床结果

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100 项与 Donor Derived HIV-Specific T-cells (DD HST-NEETs)(Children's National Research Institute) 相关的转化医学

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100 项与 Donor Derived HIV-Specific T-cells (DD HST-NEETs)(Children's National Research Institute) 相关的专利（医药）

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100 项与 Donor Derived HIV-Specific T-cells (DD HST-NEETs)(Children's National Research Institute) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
艾滋病相关性淋巴瘤	临床2期	美国	National Heart, Lung & Blood Institute	2021-10-25
达里耶病	临床1期	美国	Children's Research Institute, Inc.	2020-05-01
HIV感染	临床1期	美国	Children's Research Institute, Inc.	2020-05-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03485963 (RESIST, ASH2022) 人工标引	临床1期	HIV感染	6	HST-NEETs	(蓋醖範壓糧衊遞憲鬱廠) = HST-NEETs are safe, can elicit expansion and persistence of HIV-specific T cell populations post-infusion even without prescribed lymphodepletion, and may be associated with durable decreases in the HIV reservoir 夢選艱齋網鑰構艱鏇夢 (襯範構蓋願餘選選鏇醖 )	积极	2022-11-15