BFP-002(BFP-002) - 在研适应症：社区获得性呼吸道感染，囊性纤维化，假单胞菌感染_专利_临床

概要

基本信息

药物类型

小分子化药

别名

antibiofilm non-antibiotic(BioFilm Pharma)

靶点-

作用机制-

治疗领域

感染遗传病与畸形消化系统疾病+ [2]

在研适应症

社区获得性呼吸道感染囊性纤维化假单胞菌感染+ [2]

非在研适应症-

原研机构

Biofilm Pharma初创企业

在研机构

Biofilm Pharma初创企业

非在研机构-

最高研发阶段药物发现

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 BFP-002 相关的临床结果

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100 项与 BFP-002 相关的转化医学

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100 项与 BFP-002 相关的专利（医药）

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1

项与 BFP-002 相关的文献（医药）

2017-05-01·Experimental & Molecular Medicine2区 · 医学

Bone-forming peptide-2 derived from BMP-7 enhances osteoblast differentiation from multipotent bone marrow stromal cells and bone formation

2区 · 医学

ArticleOA

作者: Park, Kyung Soon ; Yoon, Taek Rim ; Kim, Ji Hyun ; Jeong, Myung Ho ; Kim, Hyung Keun ; Lee, Jun Sik ; Seon, Jong Keun

Strategies for efficient osteogenic differentiation and bone formation from stem cells would have clinical applications in treating nonunion fracture healing. Many researchers have attempted to develop adjuvants as specific stimulators of bone formation for therapeutic use in patients with bone resorption. Therefore, development of specific stimulators of bone formation has therapeutic significance in the treatment of osteoporosis. To date, investigations of the mature forms of bone morphogenetic proteins (BMPs) have focused on regulation of bone generation. However, we previously identified new peptides from the immature precursor of BMP, and further analysis of these proteins should be performed. In this study, we identified a new peptide called bone-forming peptide-2 (BFP-2), which has stronger osteogenic differentiation-promoting activity than BMP-7. BFP-2 treatment of multipotent bone marrow stromal cells (BMSCs) induced expression of active alkaline phosphatase. In addition, BFP-2 enhanced CD44 and CD51 expression levels and increased Ca²⁺ content in BMSCs. Moreover, radiography at 8 weeks revealed that animals that had received transplants of BFP-2-treated BMSCs showed substantially increased bone formation compared with animals that had received BMSCs treated with BMP-7. Our findings indicate that BFP-2 may be useful in the development of adjuvant therapies for bone-related diseases.

100 项与 BFP-002 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
社区获得性呼吸道感染	药物发现	法国	Biofilm Pharma初创企业	-
囊性纤维化	药物发现	法国	Biofilm Pharma初创企业	-
假单胞菌感染	药物发现	法国	Biofilm Pharma初创企业	-
慢性阻塞性肺疾病	药物发现	法国	Biofilm Pharma初创企业	-
葡萄球菌感染	药物发现	法国	Biofilm Pharma初创企业	-