1区 · 医学
Article
作者: Hristopoulos, Maria ; Laing, Steven T. ; Lee, Genee ; Totpal, Klara ; Polson, Andrew G. ; Prell, Rodney A. ; Sukumaran, Siddharth ; Zhang, Crystal ; Lin, Kedan ; Tam, Lucinda ; Mathieu, Mary ; Dennis, Mark S. ; Vuillemenot, Brian R. ; Stainton, Shannon ; Gu, Chen ; Nguyen, Allen ; Newman, Robert ; Ellerman, Diego ; Lu, Elizabeth ; Leong, Steven R. ; Zheng, Bing ; Wong, Alfred ; Chu, Yu-Waye
Key PointsBispecific antibodies binding CD3 and CLL-1 deplete CLL-1+ target cells in animal models. An appropriately engineered CLL-1/CD3 bispecific antibody could be effective in treating AML.