重组人心钠肽 (中国医学科学院)(Recombinant human Atrial Natriuretic Peptide(Chinese Academy of Medical Sciences))

Analysis of circulating tumor cells(CTCs) and clinical significance of CTCs; human atrial natriuretic peptide during perioperative period for completely resected non-small cell lung cancer: a multicentre, open-label, randomised controlled trial - Analysis of circulating tumor cells in the clinical study of ANP administration for lung cancer surgery (JANP study) (Subanalysis of JANP study)

开始日期2015-10-15

申办/合作机构

Graduate School of Medicine Osaka University

JPRN-UMIN000018480 / Completed临床2/3期IIT

Human atrial natriuretic peptide during perioperative period for completely resected non-small cell lung cancer: a multicentre, open-label, randomised controlled trial - Japan Human Atrial Natriuretic Peptide for Lung Cancer Surgery (JANP study)

开始日期2015-09-01

申办/合作机构-

JPRN-UMIN000003821 / CompletedIIT

Efficacy of human atrial natriuretic peptide for the patients with severe sepsis; Impact on prevention against acute kidney injury - SANP

开始日期2010-07-01

申办/合作机构-

100 项与重组人心钠肽 (中国医学科学院) 相关的临床结果

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100 项与重组人心钠肽 (中国医学科学院) 相关的专利（医药）

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132

项与重组人心钠肽 (中国医学科学院) 相关的文献（医药）

2024-04-01·The Kobe journal of medical sciences

HELLP Syndrome at 20 Gestational Weeks Managed Using the Mississippi Protocol: A Case Report.

Article

作者: Tanaka, Masayuki ; Masuko, Naohisa ; Terai, Yoshito ; Imafuku, Hitomi ; Tanimura, Kenji ; Deguchi, Masashi ; Takahashi, Ryosuke ; Uchida, Akiko

Hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome is one of the most severe complications of hypertensive disorders of pregnancy. HELLP syndrome occurring before 22 gestational weeks (GWs) is extremely rare, and patients prevalently exhibit underlying maternal diseases or fetal abnormalities. Here, we report the case of a pregnant woman who had HELLP syndrome at 20 GWs without any obvious underlying maternal diseases or fetal abnormalities. A 38-year-old pregnant woman was referred to Kobe University Hospital from another hospital at 19 + 5/7 GWs for hypertension, proteinuria, generalized edema, and fetal growth restriction. She was diagnosed with partial HELLP syndrome according to the Mississippi classification at 20 + 2/7 GWs. The patient was managed following the Mississippi protocol, including intravenous dexamethasone, magnesium sulfate, and antihypertensive drugs. She received intensive blood pressure and laboratory data monitoring using an arterial line and additional treatments, including platelet transfusion, intravenous haptoglobin infusion, and human atrial natriuretic peptide. The pregnancy ended in an induced delivery at 20 + 3/7 GWs, and she was discharged without complications 10 days postnatal. We performed laboratory tests for diagnosing underlying diseases but identified no obvious underlying diseases. This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.

2023-08-01·Journal of Cerebral Blood Flow & Metabolism

Reversal of the detrimental effects of social isolation on ischemic cerebral injury and stroke-associated pneumonia by inhibiting small intestinal γδ T-cell migration into the brain and lung

Article

作者: Yuan, Shiying ; Zhang, Jiancheng ; Han, Mengqi ; Hashimoto, Kenji ; Shang, You ; Chen, Xiaoyan ; Wang, Mengyuan ; Zhang, Yujing ; Yu, Yuan ; Xie, Bing ; Wu, Yuming

Social isolation (ISO) is associated with an increased risk and poor outcomes of ischemic stroke. However, the roles and mechanisms of ISO in stroke-associated pneumonia (SAP) remain unclear. Adult male mice were single- or pair-housed with an ovariectomized female mouse and then subjected to transient middle cerebral artery occlusion. Isolated mice were treated with the natriuretic peptide receptor A antagonist A71915 or anti-gamma-delta (γδ) TCR monoclonal antibody, whereas pair-housed mice were treated with recombinant human atrial natriuretic peptide (rhANP). Subdiaphragmatic vagotomy (SDV) was performed 14 days before single- or pair-housed conditions. We found that ISO significantly worsened brain and lung injuries relative to pair housing, which was partially mediated by elevated interleukin (IL)-17A levels and the migration of small intestine-derived inflammatory γδ T-cells into the brain and lung. However, rhANP treatment or SDV could ameliorate ISO-exacerbated post-stroke brain and lung damage by reducing IL-17A levels and inhibiting the migration of inflammatory γδ T-cells into the brain and lung. Our results suggest that rhANP mitigated ISO-induced exacerbation of SAP and ischemic cerebral injury by inhibiting small intestine-derived γδ T-cell migration into the lung and brain, which could be mediated by the subdiaphragmatic vagus nerve.

2021-08-01·Biological Psychiatry Global Open Science

(R,S)-Ketamine Promotes Striatal Neurogenesis and Sensorimotor Recovery Through Improving Poststroke Depression–Mediated Decrease in Atrial Natriuretic Peptide

Article

作者: Yuan, Yin ; Xie, Bing ; Yuan, Shiying ; Xiao, Ping ; Zhang, Jiancheng ; Zhang, Yujing ; Shang, You ; Zhou, Ting ; Wu, Yuming

BackgroundPoststroke social isolation could worsen poststroke depression and dampen neurogenesis. (R,S)-ketamine has antidepressant and neuroprotective effects; however, its roles and mechanisms in social isolation-mediated depressive-like behaviors and sensorimotor recovery remain unclear.MethodsMice were subjected to transient middle cerebral artery occlusion, and then were pair-housed with ovariectomized female mice or were housed isolated (ISO) starting at 3 days postischemia. ISO mice received 2 weeks of (R,S)-ketamine treatment starting at 14 days postischemia. Primary ependymal epithelial cells and choroid plexus epithelial cells were cultured and treated with recombinant human atrial natriuretic peptide (ANP) protein.ResultsThe poststroke social isolation model was successfully established using middle cerebral artery occlusion combined with poststroke isolation, as demonstrated by a more prominent depression-like phenotype in ISO mice compared with pair-housed mice. (R,S)-ketamine reversed ISO-mediated depressive-like behaviors and increased ANP levels in the atrium. The depression-like phenotype was negatively correlated with ANP levels in both the atrium and plasma. Atrial GLP-1 and GLP-1 receptor signaling was essential to the promoting effects of (R,S)-ketamine on the synthesis and secretion of ANP from the atrium in ISO mice. (R,S)-ketamine also increased ANP and TGF-β1 levels in the choroid plexus of ISO mice. Recombinant human ANP increased TGF-β1 levels in both the primarily cultured ependymal epithelial cells and choroid plexus epithelial cells. Furthermore, (R,S)-ketamine increased TGF-β1 levels in the ischemic hemisphere and promoted striatal neurogenesis and sensorimotor recovery via ANP in ISO mice.Conclusions(R,S)-ketamine alleviated poststroke ISO-mediated depressive-like behaviors and thus promoted striatal neurogenesis and sensorimotor recovery via ANP.

100 项与重组人心钠肽 (中国医学科学院) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
心脏衰竭	临床3期	中国	深圳大学	-
心脏衰竭	临床3期	中国	中国医学科学院	-
心脏衰竭	临床3期	中国	深圳市卫光生物制品股份有限公司	-