ES-009

9月26日，科望医药（Elpiscience）宣布其抗LILRB2单抗药物ES009在澳大利亚开展的1期临床试验完成首例受试者给药。该项试验旨在评估该药物的安全性、耐受性、药代动力学和药效动力学，并初步探索其抗肿瘤活性。 科望医药是一家临床阶段的生物医药公司，致力于开发新一代肿瘤免疫创新疗法。ES009是该公司开发的一款抗LILRB2单抗。其中，LILRB2（ILT4）是一种广泛表达在髓系细胞表面的抑制性受体，对肿瘤微环境中免疫抑制的形成起着关键作用。 根据科望医药新闻稿介绍，ES009能够特异性地与人LILRB2一个独特表位结合，可高效阻断LILRB2与多种配体分子间的相互作用。通过阻断LILRB2介导的抑制信号，ES009可将抑炎型髓系细胞重编程为促炎表型，并重振T细胞功能。在临床前研究中，ES009在解除肿瘤微环境免疫抑制、促进抗肿瘤免疫中已显示出巨大潜力。 科望医药首席科学官卢宏韬博士表示：“LILRB2是肿瘤免疫的关键免疫检查点，目前已证明它的免疫抑制作用是引起PD(L)1抑制剂耐药的机制之一。我们希望能为对PD(L)1抑制剂无反应或耐药的患者带来更有效的肿瘤免疫疗法，ES009在临床前研究中已展现出同类最佳的潜力。我们相信通过激发人体固有免疫系统来抗击癌症具有非常大的治疗潜力，并已研发出一系列高度差异化的、靶向髓系细胞免疫检查点的药物管线。我们将继续保持高效的研发势头，将更多肿瘤免疫创新疗法尽快带给全球癌症患者，满足未被满足的临床需求。”‍‍ 参考资料：[1]科望医药抗LILRB2单抗ES009在澳洲完成首例患者给药. Retrieved Sep 26，2023. From https://mp.weixin.qq.com/s/SmbIf0bpyzUCbvsBODix_Q 内容来源于网络，如有侵权，请联系删除。

SHANGHAI & SUZHOU, China & GERMANTOWN, Md.--(BUSINESS WIRE)-- Elpiscience Biopharma (“Elpiscience”), a clinical-stage biopharmaceutical company dedicated to discovering and developing next-generation cancer immunotherapies, announced today that the first patient has been dosed in a Phase 1 clinical trial of its anti-LILRB2 monoclonal antibody ES009 in Australia. The objective of the trial is to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary clinical activity. LILRB2, also known as ILT4, is an inhibitory receptor widely expressed on the surface of myeloid cells that also contributes significantly to immune suppression in the tumor microenvironment (TME). ES009 specifically binds to a unique epitope on human LILRB2 and potently blocks LILRB2 binding to multiple ligands. By blocking LILRB2-mediated inhibitory signaling, ES009 can reprogram myeloid cells from anti-inflammatory phenotype into pro-inflammatory phenotype, and reinvigorate T cell functionalities. ES009 has demonstrated exceptional potential to reverse immune suppression in the TME and promote anti-tumor immunity in preclinical studies. “LILRB2 is a key immune checkpoint for tumor immunotherapy whose suppression of immune response is proved as one mechanism of anti-PD(L)1 resistance. With a keen interest in revolutionizing therapies for cancer patients non-responsive or resistant to PD(L)1 treatment, we developed ES009 which has shown best-in-class potential. We believe in the power of enhanced innate immunity in treating cancer and have developed a highly differentiated myeloid cell focused therapeutics portfolio. We will work relentlessly to bring these highly promising therapies to cancer patients with unmet medical needs,” said Dr. Hongtao Lu, Co-founder and CSO of Elpiscience. About Elpiscience Elpiscience is a clinical-stage biopharmaceutical company dedicated to developing life-changing immuno-oncology therapies for cancer patients worldwide. The company’s innovative approach is focused on removing immunosuppressive factors in the tumor microenvironment, by targeting the adenosine pathway and myeloid checkpoints. A pipeline of novel molecules has been developed using its proprietary platforms including a powerful Bispecific Macrophage Engager (BiME®) technology that connects and activates macrophages for solid tumor killing without causing cytokine storms. For more information, please visit: